Abstract: Provided herein are methods for inhibiting PCSK9, reducing PCSK9 levels, and for treating or preventing related conditions and disorders, in a subject, which includes administering to a subject an effective amount of a compound which includes derivatized cycloalkyl[b]indoles, e.g., cyclopenta-, cyclohexa- and cyclohepta[b]indoles.

Abstract: Systems, methods, and instruments for tracking localized movement of an anatomic structure at a surgical site are provided that can, for example, detect and identify movement of the anatomic structure not otherwise tracked by a global navigation system. One embodiment can include a cannula with a localized navigation sensor coupled to a distal end thereof. The cannula can be coupled to a robot arm and the localized navigation sensor can detect movement of an anatomic structure relative to the cannula. The localized navigation sensor can include one or more tines that selectively extend from the cannula to contact the anatomic structure. A controller can receive data from the localized navigation sensor and a global navigation system, and determine if movement detected by the localized navigation sensor is tracked by the global navigation system. Systems, methods, and instruments of the present disclosure can be used independently of a global navigation system.

Abstract: Provided herein are methods for inhibiting PCSK9, reducing PCSK9 levels, and for treating or preventing related conditions and disorders, in a subject, which includes administering to a subject an effective amount of a compound which includes derivatized cycloalkyl[b]indoles, e.g., cyclopenta-, cyclohexa- and cyclohepta[b]indoles.

Abstract: A method and system for optimizing N dimensional volume data for transmission is disclosed. The device and method including organizing points based on XYZ location, into volumes, which are recursively divided by N into smaller volumes, where N is greater than 1, and decompressing each volume, by encoding a reference volume then encoding the remaining volumes as a distance from the reference cuboid or the most recently recorded cuboid.

Abstract: A method and system for optimizing N dimensional volume data for transmission is disclosed. The device and method including organizing points based on XYZ location, into volumes, which are recursively divided by N into smaller volumes, where N is greater than 1, and decompressing each volume, by encoding a reference volume then encoding the remaining volumes as a distance from the reference cuboid or the most recently recorded cuboid.

Abstract: A method of synthesizing cycloalkanyl[b]indoles, as well as related cycloalkanyl[b]benzofurans and cycloalkanyl[b]benzothiophenes is provided. The method is a single, multicomponent reaction that combines (1) an indole, benzofuran, or benzothiopene, (2) an aldehyde, ketone, or ketal, and (3) a diene in the presence of an acid, in particular a Ga(III) or In(III) salt. Compositions and methods of using these compounds to stimulate secretion and/or production of glucagon-like peptide-1 or inhibit the activity of Calcitonin Gene-Related Peptide receptor are also provided.

Abstract: A method and system for optimizing N dimensional volume data for transmission is disclosed. The device and method including organizing points based on XYZ location, into volumes, which are recursively divided by N into smaller volumes, where N is greater than 1, and decompressing each volume, by encoding a reference volume then encoding the remaining volumes as a distance from the reference cuboid or the most recently recorded cuboid.

Abstract: A method of internally heating a power supply of an electronic device in reduced temperatures is provided. The method comprises positioning an antenna of the electronic device proximate to the power supply and receiving a “temperature” signal that is a function of a temperature of the power supply. When it is determined that the temperature is within a reduced operating-temperature range, the temperature is elevated and the equivalent series resistance (ESR) of the power supply is correspondingly reduced by actively sending current through the antenna. The “current sending” operation is reduced when the temperature of the portable electronic device is outside the reduced operating-temperature range.

Abstract: A low magnetic interference battery is provided, the battery insertable into a mobile communication device, the mobile communication device comprising a radio interconnected with a microphone and a receiver. The battery comprises a battery portion enabled to provide electrical power to the radio, the battery portion emitting a magnetic field when in operation. The battery further comprises a sealing portion for sealing the battery portion therein such that the battery portion is protected from moisture, the sealing portion comprising a magnetic shield portion arranged relative to the battery portion such that magnetic flux from the battery portion is routed away from the receiver when the battery is in operation in the mobile communication device.

Abstract: An attachment for a fuel tank of a fuel cell powered system is described. The attachment thermally conducts heat generated from an electronic component to the fuel tank. The attachment further affixes to the electronic component by a securing portion. In one aspect, the attachment is comprised in a fuel cell powered electronic device. In another aspect, the attachment is integral to the fuel tank.

Abstract: Systems and methods are provided for downloading battery data to a mobile communication device. A system for downloading battery data to a mobile communication device may include a mobile communication device and a data server. The mobile communication device may be configured to monitor a battery operating condition and to receive a battery profile, the battery profile including battery data for use by the mobile communication device to calculate battery status information. The data server may be used for storing battery data, the data server being configured to receive the battery operating condition from the mobile communication device and, based on the battery operating condition, send the battery profile to the mobile communication device.

Abstract: Systems and methods are disclosed for detecting whether a battery in an electronic device is counterfeit or defective. An actual battery characteristic profile is generated by recording the performance of the battery during use of the battery by the device. This profile is then compared to its corresponding expected characteristic profile. If the profiles are not substantially similar (i.e. if the error between the two curves exceeds a given error threshold), the battery is determined to be counterfeit or defective and responsive action is taken.

Abstract: A method and system for optimizing N dimensional volume data for transmission is disclosed. The device and method including organizing points based on XYZ location, into volumes, which are recursively divided by N into smaller volumes, where N is greater than 1, and decompressing each volume, by encoding a reference volume then encoding the remaining volumes as a distance from the reference cuboid or the most recently recorded cuboid.

Abstract: A method of internally heating a power supply of an electronic device in reduced temperatures is provided. The method comprises positioning an antenna of the electronic device proximate to the power supply and receiving a “temperature” signal that is a function of a temperature of the power supply. When it is determined that the temperature is within a reduced operating-temperature range, the temperature is elevated and the equivalent series resistance (ESR) of the power supply is correspondingly reduced by actively sending current through the antenna. The “current sending” operation is reduced when the temperature of the portable electronic device is outside the reduced operating-temperature range.

Abstract: A method of synthesizing cycloalkanyl[b]indoles, as well as related cycloalkanyl[b]benzofurans and cycloalkanyl[b]benzothiophenes is provided. The method is a single, multicomponent reaction that combines (1) an indole, benzofuran, or benzothiopene, (2) an aldehyde, ketone, or ketal, and (3) a diene in the presence of an acid, in particular a Ga(III) or In(III) salt. Compositions and methods of using these compounds to stimulate secretion and/or production of glucagon-like peptide-1 or inhibit the activity of Calcitonin Gene-Related Peptide receptor are also provided.

Abstract: The disclosure is directed at a method and apparatus for controlling fuel cell operating characteristics. In certain situations, the operating efficiency of fuel cells is degraded to external conditions. Providing a method and apparatus to control operating conditions for the fuel cell assists in improving the operating efficiency. This can be achieved by controlling certain environmental conditions, such as temperature and relatively humidity, in the area surrounding the fuel cell.

Abstract: The present invention is a method for promoting hydrothiolation of an unactivated alkenes with a thiol using gallium triflate.

Abstract: A method includes: receiving a temperature indication, the temperature indication being a function of a temperature of a power pack of a portable electronic device; determining, as a function of the temperature indication, whether the temperature is within an elevated operating temperature range; and reducing a charge termination voltage and a charging current when the temperature is within the elevated operating temperature range.

Abstract: According to one aspect, a mobile electronic device having a fuel cell configured to receive fuel and generate therefrom electrical power for the mobile electronic device, a fuel tank adapted to store fuel and provide fuel to the fuel cell, and a solid-state battery configured to provide power to the mobile device. The solid-state battery is sized and shaped to at least partially surround at least one of the fuel cell and the fuel tank.

Abstract: A low magnetic interference battery is provided, the battery insertable into a mobile communication device, the mobile communication device comprising a radio interconnected with a microphone and a receiver. The battery comprises a battery portion enabled to provide electrical power to the radio, the battery portion emitting a magnetic field when in operation. The battery further comprises a sealing portion for sealing the battery portion therein such that the battery portion is protected from moisture, the sealing portion comprising a magnetic shield portion arranged relative to the battery portion such that magnetic flux from the battery portion is routed away from the receiver when the battery is in operation in the mobile communication device.