Abstract: The invention provides compounds, methods, and pharmaceutical compositions for reducing the amount or activity of Apolipoprotein E (ApoE) mRNA, and in certain embodiments reducing the amount of ApoE protein in a cell or animal, wherein reducing the amount or activity of ApoE would be beneficial.

Abstract: The invention provides compounds, methods, and pharmaceutical compositions for reducing the amount or activity of N-acylsphingosine amidohydrolase (acid ceramidase) 1 (ASAH1) mRNA, and in certain embodiments reducing the amount of ASAH1 protein in a cell or animal, wherein reducing the amount or activity of ASAH1 would be beneficial.

Abstract: Disclosed herein are compounds, compositions, and methods for decreasing TIGIT mRNA and protein expression. Such methods are useful to treat, prevent, or ameliorate TIGIT associated diseases, disorders, and conditions.

Abstract: Disclosed herein are compounds, compositions, and methods for decreasing TIGIT mRNA and protein expression. Such methods are useful to treat, prevent, or ameliorate TIGIT associated diseases, disorders, and conditions.

Abstract: A chassis includes a base, a lid, and air baffles disposed within the base. The lid slidably engages opposing base side walls and slides between secured and unsecured positions. In one embodiment, a mechanical latch attaches to the lid and has a spring-biased latch arm for selectively locking the lid to the base and a latch hook for selectively locking the air baffle to the lid, wherein depressing the mechanical latch releases the lid from the base and physically separating the lid from the base causes the latch hook to secure the air baffle for removing the air baffle along with the lid. In another embodiment, a first magnet is attached to the lid and a second magnet is attached to the air baffle, wherein sliding the lid to the unsecured position aligns the first and second magnets and magnetically couples the air baffle to the lid.

Abstract: A chassis includes a base, a lid, and air baffles disposed within the base. The lid slidably engages opposing base side walls and slides between secured and unsecured positions. In one embodiment, a mechanical latch attaches to the lid and has a spring-biased latch arm for selectively locking the lid to the base and a latch hook for selectively locking the air baffle to the lid, wherein depressing the mechanical latch releases the lid from the base and physically separating the lid from the base causes the latch hook to secure the air baffle for removing the air baffle along with the lid. In another embodiment, a first magnet is attached to the lid and a second magnet is attached to the air baffle, wherein sliding the lid to the unsecured position aligns the first and second magnets and magnetically couples the air baffle to the lid.

Abstract: A method and computer program product secure a hot-swap data storage device against being manually physically removed from an operable position within a chassis bay of a computer system. The hot-swap data storage device is released to be manually physically removed from the operable position within the chassis bay of the computer system in response to determining that the data storage device is not active. The hot-swap data storage device may, for example, be secured and released using an electronically-actuated lock.

Abstract: A method and computer program product secure a hot-swap data storage device against being manually physically removed from an operable position within a chassis bay of a computer system. The hot-swap data storage device is released to be manually physically removed from the operable position within the chassis bay of the computer system in response to determining that the data storage device is not active. The hot-swap data storage device may, for example, be secured and released using an electronically-actuated lock.

Abstract: The invention provides passivated organic polymer supports, processes for their preparation and processes for their use in oligonucleotide synthesis that allow for highly efficient solid phase synthesis of oligonucleotides.

Abstract: The invention provides passivated organic polymer supports, processes for their preparation and processes for their use in oligonucleotide synthesis that allow for highly efficient solid phase synthesis of oligonucleotides.