Abstract: Periodic electrical signal data, such as electrocardiogram signal data, is collected, analyzed, and transformed into compacted, multi-dimensional matrix that makes it easier for healthcare professionals to analyze the health condition of a patient. The electrical signal data, characterized by periodic deflection elements that collectively form a periodic signal complex, is analyzed to determine peaks of deflection elements, where peaks can vary greatly, but in ways not readily visible on standard electrocardiograms. The techniques create and display the multi-dimensional matrix from aligning identified peaks, so that the matrix can be readily overlayed with an automatically-identified signal pattern indicative of one or more of an arrhythmia, a precursor to an arrhythmia, a cardiac event, and/or a precursor to a cardiac even.

Abstract: Periodic electrical signal data, such as electrocardiogram signal data, is collected, analyzed, and transformed into compacted, multi-dimensional matrix that makes it easier for healthcare professionals to analyze the health condition of a patient. The electrical signal data, characterized by periodic deflection elements that collectively form a periodic signal complex, is analyzed to determine peaks of deflection elements, where peaks can vary greatly, but in ways not readily visible on standard electrocardiograms. The techniques create and display the multi-dimensional matrix from aligning identified peaks, so that the matrix can be readily overlayed with an automatically-identified signal pattern indicative of one or more of an arrhythmia, a precursor to an arrhythmia, a cardiac event, and/or a precursor to a cardiac even.

Abstract: The invention is directed to a new method for long-term measurement of daily serotonin (5-HT) and melatonin contents in the pineal gland. The disclosed method allows visualization of the pineal gland for accurate targeting of the guide cannula which minimizes bleeding, incurs no direct injury to the surrounding brain tissue and cause no interference with the sympathetic innervation from the superior cervical ganglion. The improved method allows effects of pharmacological agents on in vivo pineal gland circulation to be studied reproducibly over time and gene expression profiles correlated with physiological consequences in the same or different individuals. More importantly, the method allows accurate assessment of the endogenous circadian clock function. The method can be used for high throughput screening to identify candidate agents which may accelerate adaptation to new time zones, to alleviate symptoms resulting from jet lag, frequent shift work sleep abnormalities and seasonal affective illnesses.