Abstract: An application of a biomarker in preparing metabolic dysfunction-associated steatotic liver disease classification products is provided. The biomarker is any one or more of the following: a combination of liver protein biomarkers, a combination of serum protein biomarkers, a combination of serum lipid biomarkers, a combination of serum metabolite biomarkers, a combination of serum protein, lipid and metabolite biomarkers, a combination of urine protein biomarkers, a combination of urine metabolite biomarkers, and a combination of urine protein and metabolite biomarkers; and the metabolic dysfunction-associated steatotic liver disease is divided into a metabolically active type, a high-risk type of cirrhosis and a high-risk type of hepatocellular carcinoma. The combinations of biomarkers provided by the present disclosure have a good effect on the diagnosis of three MASLD molecular subtypes, which provides technical support for the classification and diagnosis of MASLD.

Abstract: Disclosed are coating equipment and a coating method. The coating equipment comprises a coating die and a slurry parameter detector. The coating die comprises a first slot, a second slot, a first adjusting mechanism and a second adjusting mechanism. Through the arrangement of the first adjusting mechanism and the second adjusting mechanism, adjustment of the flow rate of slurry circulating in the first slot and the second slot can be realized, and parameters of coated slurry are detected by a slurry parameter detector, and are then compared with preset values, and comparison results are fed back to the first adjusting mechanism and the second adjusting mechanism for adjustment of the first adjusting piece and the second adjusting piece, so that automatic adjustment of double-layer die coating is realized, the debugging effectiveness is greatly improved, and the coating efficiency is further improved.

Abstract: Disclosed are coating equipment and a coating method. The coating equipment comprises a coating die and a slurry parameter detector. The coating die comprises a first slot, a second slot, a first adjusting mechanism and a second adjusting mechanism. Through the arrangement of the first adjusting mechanism and the second adjusting mechanism, adjustment of the flow rate of slurry circulating in the first slot and the second slot can be realized, and parameters of coated slurry are detected by a slurry parameter detector, and are then compared with preset values, and comparison results are fed back to the first adjusting mechanism and the second adjusting mechanism for adjustment of the first adjusting piece and the second adjusting piece, so that automatic adjustment of double-layer die coating is realized, the debugging effectiveness is greatly improved, and the coating efficiency is further improved.

Abstract: A molecular marker for diagnosing primary biliary cholangitis and a method for detecting same are provided. The anti-human multimer immunoglobulin receptor antibody is adopted as the primary biliary cholangitis diagnosis molecular marker so as to prepare the diagnosis reagent; the human multimer immunoglobulin receptor antibody is remarkably increased in serum of PBC AMA-M2 subtype positive and negative patients, which indicates that in the attack of PBC, the serum anti-human multimer immunoglobulin receptor antibody specifically targets human multimer immunoglobulin receptors on small and medium bile ducts in the liver, thereby causing damage to the small and medium bile ducts.