Publication number: 20220348663
Abstract: Provided are an anti-B7-H3 antibody binding specifically to B7-H3 and a use thereof and, more particularly, are an anti-B7-H3 antibody or an antigen binding fragment thereof, a nucleic acid encoding the same, a vector carrying the nucleic acid, a cell transformed with the vector, a method for preparing the same, an antibody-drug conjugate or a multi-specific antibody comprising the same, and a pharmaceutical composition for preventing or treating cancer, autoimmune disease, or inflammatory disease, or a diagnostic composition, each composition comprising the same. The anti-B7-H3 antibody or antigen binding fragment thereof can bind to human and non-human B7-H3 at high affinity and can be endocytosized after binding thereto. Thus, the anti-B7-H3 antibody or antigen binding fragment thereof, or the antibody-drug conjugate or the multi-specific antibody comprising the same can be advantageously used for preventing, treating, or diagnosing cancer or tumor, autoimmune disease, or inflammatory disease.
Type:
Application
Filed:
July 8, 2020
Publication date:
November 3, 2022
Inventors:
Hyun Ju LEE, Eun-Young SHIM, Yunjung KO, Jin-Chul YOUN, Jae Eun PARK, Soo A CHOI, Seok Ho YOO, Dong Jung LEE, Yeung-Chul KIM, Youngja SONG, Jisu LEE, Ju-Ry LIM, Bum-Chan PARK, Young Woo PARK