Abstract: Provided herein is a pharmaceutical composition comprising two or more compounds, wherein each compound is independently a phosphodiesterase inhibitor, an adenosine receptor antagonist, a calcium channel blocker, a histamine H1-receptor agonist, a histamine H2-receptor agonist, a histamine H3-receptor antagonist, or a ?2-adrenoreceptor agonist. Also provided herein is a method of treating, preventing, or ameliorating a cardiovascular disease in a subject, comprising administering to the subject in need thereof two or more compounds, wherein each compound is independently a phosphodiesterase inhibitor, an adenosine receptor antagonist, a calcium channel blocker, a histamine H1-receptor agonist, a histamine H2-receptor agonist, a histamine H3-receptor antagonist, or a ?2-adrenoreceptor agonist.

Abstract: This invention relates to a method for toxicity comprehensive elimination of chrome residues, comprising adding water to chrome residues, wet-grinding the same to a thick liquid, letting it react with dilute hydrochloric acid, and letting the filtrate obtained react with an additive containing barium, with sulfuric acid or magnesium sulfate, and with cream of lime or soda, so as to realize a comprehensive extraction and utilization of various elements. The hydrochloric acids can be circulated, and the filter residues can be used for iron-smelting and brick-making. By means of this method, it is possible not only to completely and permanently eliminate the toxicity of the residues, but also to realize a comprehehsive utilization of the residue resources.