Abstract: The present invention relates to a vacuum drying method for botulinum toxin, and specifically to a vacuum drying method for botulinum toxin, comprising the steps of: a) first drying of a solution containing botulinum toxin at a temperature of 5° C. to 30° C. under a pressure of 0.01 to 2 mmHg; b) a second drying of the first-dried product obtained in step a) at a temperature of 5° C. to 20° C. under a pressure of 0.01 to 1 mmHg; and c) final drying of the second-dried product obtained in step b) at a temperature of 5° C. to 30° C. under a pressure of 0.01 to 0.5 mmHg. The present invention can advantageously improve yield, stability and manufacturing efficiency, compared to conventional methods for vacuum drying botulinum toxin by freeze-drying.

Abstract: The present invention relates to a container lid, and a container assembly having same coupled thereto and, more specifically, to a container lid coupled to a container inlet through which contents are received, and a container assembly having the container lid coupled thereto. Disclosed is a container assembly comprising: a container for receiving contents; a container lid coupled to the container inlet; and a sealing member having a bottom surface attached to an upper end of the container inlet of the container, and coupled to the container lid, wherein, when the container lid is separated from the container by means of rotation, adhesiveness between the sealing member and the container lid is greater than adhesiveness between the container inlet and the sealing member such that the sealing member is separated from the container inlet.

Abstract: Provided are a container cap coupled to the mouth of a container in which contents are contained; and a container to which the container cap is coupled. The container cap includes: a main body part coupled to a container inlet of a container and having an opening formed on an upper side thereof; a cover part connected to the main body part by a hinge part and opening and closing an upper opening of the main body part by hinge rotation; a separation part connected to the cover part by a first connection part and connected to the main body part by a second connection part detachably; and a fixing part formed on the cover part so that the separation part is fixedly coupled thereto after the second connection part is separated by a user's manipulation so that the cover part can be separated from the main body part.

Abstract: A container cap which is combined with a container containing a beverage or the like, and a container combined with the container cap. The container cap is combined with a container inlet of a container body. A plurality of close contact portions in contact with the container inlet are formed, and the close contact portions form a closed curve enclosing the container inlet so as to block inflow of external air from the outside into the container body.

Abstract: The present invention relates to a container cap and, more specifically, to: a container cap which is coupled to the mouth of a container in which contents are contained; and a container having same coupled thereto. The present invention provides a container cap comprising: a body part coupled to the mouth of a container in which contents are contained, and having an opening at the top thereof, a cover part coupled to the body part so as to open and close the top opening of the body part; and a separation part integrally connected to a first member, which is one of the body part and the cover part, by a first connection part, and integrally but detachably connected to a second member, which is the other of the body part and the cover part, by a second connection part, wherein the second connection part is detached by a user's manipulation so as to allow the cover part to be separated from the body part.

Abstract: Provided are a container cap coupled to the mouth of a container in which contents are contained; and a container to which the container cap is coupled. The container cap includes: a main body part coupled to a container inlet of a container and having an opening formed on an upper side thereof; a cover part connected to the main body part by a hinge part and opening and closing an upper opening of the main body part by hinge rotation; a separation part connected to the cover part by a first connection part and connected to the main body part by a second connection part detachably; and a fixing part formed on the cover part so that the separation part is fixedly coupled thereto after the second connection part is separated by a user's manipulation so that the cover part can be separated from the main body part.

Abstract: A container cap which is combined with a container containing a beverage or the like, and a container combined with the container cap. The container cap is combined with a container inlet of a container body. A plurality of close contact portions in contact with the container inlet are formed, and the close contact portions form a closed curve enclosing the container inlet so as to block inflow of external air from the outside into the container body.

Abstract: The present invention relates to a container cap and, more specifically, to: a container cap which is coupled to the mouth of a container in which contents are contained; and a container having same coupled thereto. The present invention provides a container cap comprising: a body part coupled to the mouth of a container in which contents are contained, and having an opening at the top thereof; a cover part coupled to the body part so as to open and close the top opening of the body part; and a separation part integrally connected to a first member, which is one of the body part and the cover part, by a first connection part, and integrally but detachably connected to a second member, which is the other of the body part and the cover part, by a second connection part, wherein the second connection part is detached by a user's manipulation so as to allow the cover part to be separated from the body part.

Abstract: Disclosed is a container stopper (100) coupled to a container inlet (12) of a container (10) in which content is held, the container stopper comprising: a stopper body (110) that is coupled to the container inlet (12) and has, on the upper side thereof, an auxiliary space (S1) in which auxiliary content (42) having a granular structure is held; and an upper cover (120) that is coupled to the stopper body (110), forms the auxiliary space (S1) together with the stopper body (110), and covers the auxiliary space (S1).

Abstract: A quinazoline-based compound is represented by Formula 1 or Formula 2. The compound can effectively activate the BKCa channels, and thus may be used for preventing or treating the overactive bladder caused by inactivation or decrease in activity of the BKCa channels. The compound can be included in a pharmaceutical composition or health function food for improving urinary function.

Abstract: Provided are a container cap coupled to the mouth of a container in which contents are contained; and a container to which the container cap is coupled. The container cap includes: a main body part coupled to a container inlet of a container and having an opening formed on an upper side thereof; a cover part connected to the main body part by a hinge part and opening and closing an upper opening of the main body part by hinge rotation; a separation part connected to the cover part by a first connection part and connected to the main body part by a second connection part detachably; and a fixing part formed on the cover part so that the separation part is fixedly coupled thereto after the second connection part is separated by a user's manipulation so that the cover part can be separated from the main body part.

Abstract: The present invention relates to a container cap and, more specifically, to a container cap coupled to a container inlet, and a container to which same is coupled. Disclosed is the container cap comprising: a cap body (100) coupled to a container inlet (12) of the container (10) in which contents are contained; and an upper lid (200) coupled to the cap body (100) to cover the upper side of the cap body (100), wherein the cap body (100) includes an outlet plate (110) which is fractured from an upper plate part (101) to form a discharge hole (102) through which the contents contained in the container (10) are discharged, and the upper lid (200) includes a pushing part (210) which is formed in correspondence to the outlet plate (110) and which fractures the outlet plate (110) by means of the vertical movement thereof.

Abstract: The present invention relates to a container cap and, more specifically, to: a container cap which is coupled to the mouth of a container in which contents are contained; and a container having same coupled thereto. The present invention provides a container cap comprising: a body part coupled to the mouth of a container in which contents are contained, and having an opening at the top thereof; a cover part coupled to the body part so as to open and close the top opening of the body part; and a separation part integrally connected to a first member, which is one of the body part and the cover part, by a first connection part, and integrally but detachably connected to a second member, which is the other of the body part and the cover part, by a second connection part, wherein the second connection part is detached by a user's manipulation so as to allow the cover part to be separated from the body part.

Abstract: The present invention relates to a vacuum drying method for botulinum toxin, and specifically to a vacuum drying method for botulinum toxin, comprising the steps of: a) first drying of a solution containing botulinum toxin at a temperature of 5° C. to 30° C. under a pressure of 0.01 to 2 mmHg; b) a second drying of the first-dried product obtained in step a) at a temperature of 5° C. to 20° C. under a pressure of 0.01 to 1 mmHg; and c) final drying of the second-dried product obtained in step b) at a temperature of 5° C. to 30° C. under a pressure of 0.01 to 0.5 mmHg. The present invention can advantageously improve yield, stability and manufacturing efficiency, compared to conventional methods for vacuum drying botulinum toxin by freeze-drying.

Abstract: The present invention relates to a container lid, and a container assembly having same coupled thereto and, more specifically, to a container lid coupled to a container inlet through which contents are received, and a container assembly having the container lid coupled thereto. Disclosed is a container assembly comprising: a container for receiving contents; a container lid coupled to the container inlet; and a sealing member having a bottom surface attached to an upper end of the container inlet of the container, and coupled to the container lid, wherein, when the container lid is separated from the container by means of rotation, adhesiveness between the sealing member and the container lid is greater than adhesiveness between the container inlet and the sealing member such that the sealing member is separated from the container inlet.

Abstract: Disclosed is a container stopper (100) coupled to a container inlet (12) of a container (10) in which content is held, the container stopper comprising: a stopper body (110) that is coupled to the container inlet (12) and has, on the upper side thereof, an auxiliary space (S1) in which auxiliary content (42) having a granular structure is held; and an upper cover (120) that is coupled to the stopper body (110), forms the auxiliary space (S1) together with the stopper body (110), and covers the auxiliary space (S1).

Abstract: A compound of the present invention, which is a tricyclic derivative represented by chemical formula 1 or a pharmaceutically acceptable salt thereof, has an excellent inhibitory effect on serotonin activity and a pharmaceutical composition comprising same can be thus advantageously used for preventing or treating a metabolic disease associated with serotonin activation, etc.

Abstract: A container cap which is combined with a container containing a beverage or the like, and a container combined with the container cap. The container cap is combined with a container inlet of a container body. A plurality of close contact portions in contact with the container inlet are formed, and the close contact portions form a closed curve enclosing the container inlet so as to block inflow of external air from the outside into the container body.

Abstract: The present invention relates to a botulinum toxin preparation method capable of obtaining botulinum toxin in a high yield through a simplified process that does not include animal-derived ingredients. The botulinum toxin preparation method according to the present invention does not use any animal ingredients in the overall process, including the culturing of a Clostridium botulinum strain, thereby providing excellent safety, omits a separate nucleic acid removal step using an additive treatment when compared with a conventional isolation process, and performs processing using only ion exchange chromatography, and it was confirmed that the botulinum toxin can be isolated at a remarkably improved yield through a simplified process by using the same buffer and only adjusting the concentration and pH of the buffer, and thus the present invention is a very economical and efficient isolation method so that the botulinum toxin isolated thereby is expected to be effectively used in beauty and medicine fields.

Abstract: The present invention relates to a novel tryptophan hydroxylase inhibitor and a pharmaceutical composition including same, wherein the novel tryptophan hydroxylase inhibitor has an excellent inhibitory effect on TPH1, and thus can be usefully used for the prevention or treatment of disorders, such as metabolic disorders, cancer, digestive or cardiovascular system disorders, related to TPH1 activity. In particular, the novel tryptophan hydroxylase inhibitor has an excellent treatment effect on inflammatory bowel disorders, and thus can be usefully used for the treatment of inflammatory bowel disorder.