Abstract: The present invention relates to an antigen-binding molecule comprising a heavy chain variable region comprising a heavy-chain complementarity-determining region 1 (HCDR1) comprising an amino acid sequence represented by Sequence No. 1, an HCDR2 comprising an amino acid sequence represented by Sequence No. 2, and an HCDR3 comprising an amino acid sequence represented by Sequence No. 3; a light-chain variable region comprising a light-chain complementarity-determining region 1 (LCDR1) comprising an amino acid sequence represented by Sequence No. 4, an LCDR2 comprising an amino acid sequence represented by Sequence No. 5, and an LCDR3 comprising an amino acid sequence represented by Sequence No. 6; wherein the antigen-binding molecule is a T cell receptor (TCR); and to a cell line expressing the same.

Abstract: Disclosed are novel compounds of Chemical Formula 1, optical isomers of the compounds, and pharmaceutically acceptable salts of the compounds or the optical isomers. The compounds, isomers, and salts exhibit excellent activity as GLP-1 receptor agonists. In particular, they, as GLP-1 receptor agonists, exhibit excellent glucose tolerance, thus having a great potential to be used as therapeutic agents for metabolic diseases. Moreover, they exhibit excellent pharmacological safety for cardiovascular systems.

Abstract: A display panel includes a first substrate including a display area, in which a plurality of pixel areas is arranged, and a non-display area around the display area, a second substrate disposed opposite to the first substrate, a light emitting array disposed on the first substrate and including a plurality of light emitting elements corresponding to the plurality of pixel areas, a sealing layer disposed in the non-display area between the first substrate and the second substrate and bonding the first substrate and the second substrate to each other, a vacuum layer sealed by the sealing layer and defined between the light emitting array and the second substrate, and a reflection adjustment layer disposed on the second substrate and absorbing a portion of external light, where the reflection adjustment layer includes a plurality of protrusions protruding toward the light emitting array and exposed to the vacuum layer.

Abstract: In a method for operating a microscope, a lens unit transmits a first image laser to an object, and acquire a first scan image on the basis of a first reflection signal reflected from a first area included in the object. An ultrasound conversion unit transmits an ultrasound signal to the first area and focuses same so as to form air bubbles in the first area. The lens unit transmits a second image laser to the object, and can acquire a second scan image on the basis of a second reflection signal reflected from the second area included in the object. The ultrasound conversion unit transmits an ultrasound signal to the first area included in the object and focuses same so as to form air bubbles in the first area, thereby enabling an increase in the imageable depth of a microscope.

Abstract: In a method for operating a microscope, according to an embodiment of the present invention, a lens unit transmits a first image laser to an object, and can acquire a first scan image on the basis of a first reflection signal reflected from a first area included in the object. An ultrasound conversion unit transmits an ultrasound signal to the first area and focuses same so as to form air bubbles in the first area. The lens unit transmits a second image laser to the object, and can acquire a second scan image on the basis of a second reflection signal reflected from the second area included in the object. In the method for operating a microscope, according to the present invention, the ultrasound conversion unit transmits an ultrasound signal to the first area included in the object and focuses same so as to form air bubbles in the first area, thereby enabling an increase in the imageable depth of a microscope.

Abstract: An apparatus for evaluating performance of an ultrasonic transducer includes a transducer assembly having an ultrasonic transducer and an acoustic medium and configured to transmit and receive an ultrasonic wave, a storage unit configured to store a reference signal value which represents the performance of the ultrasonic transducer, and a processing unit configured to control the transducer assembly to emit ultrasonic wave and receive a response (echo) signal thereto to measure a magnitude or energy amount of the response signal, the processing unit comparing a measured value with the reference signal value stored in the storage unit to evaluate the performance of the ultrasonic transducer.

Abstract: The present invention provides a dual-purpose photoacoustic tomography (PAT)/ultrasound contrast agent comprising: (a) a micro-bubble containing gas and porphyrin therein; and (b) nanoparticles bound on a surface of the micro-bubble and containing a drug. The contrast agent of the present invention can be used in both the ultrasound diagnosis and the photoacoustic image diagnosis, and can significantly increase the accuracy of photoacoustic images.

Abstract: The present invention relates to a method for producing an intravascular ultrasonic transducer and a structure for same, the method for producing a ultrasonic transducer producing a single element by: forming a piezoelectric element lapped according to a previously set thickness; depositing conductive material on the lapped surface of the piezoelectric element; forming a matched layer and a rear surface layer by casting the front and rear surfaces of the piezoelectric element to which conductive material has been deposited; lapping according to a previously set thickness; and dicing the bulk material, which is a stack of a matched layer, a piezoelectric element and a rear surface layer, along the stack direction so that the size of the element is less than the critical size for intravascular ultrasound (IVUS).

Abstract: The present disclosure relates to a method for generating a synthetic image. In the method, image data is generated using a receiving dynamic beamforming method, image data is generated using a synthetic aperture beamforming method, and the image data generated using the receiving dynamic beamforming method and the image data generated using the synthetic aperture beamforming method are synthesized with being applied with weighting factors according to advancing distances of ultrasonic waves. By using a zone blending method, in which image data according to a receiving dynamic beamforming method is mainly used for an ultrasonic image having a predetermined depth or less, and image data according to a synthetic aperture beamforming method is mainly used for an ultrasonic image having any other depth, a grating lobe and distortion of image brightness are eliminated.

Abstract: An apparatus for evaluating performance of an ultrasonic transducer includes a transducer assembly having an ultrasonic transducer and an acoustic medium and configured to transmit and receive an ultrasonic wave, a storage unit configured to store a reference signal value which represents the performance of the ultrasonic transducer, and a processing unit configured to control the transducer assembly to emit ultrasonic wave and receive a response (echo) signal thereto to measure a magnitude or energy amount of the response signal, the processing unit comparing a measured value with the reference signal value stored in the storage unit to evaluate the performance of the ultrasonic transducer.

Abstract: Disclosed is a method of removing a background noise from a photoacoustic image, the method including applying an ultrasonic signal to a target absorbing body having a multi-modal microbubble contrast agent injected thereinto and receiving the ultrasonic signal reflected by the target absorbing body in order to acquire an ultrasonic image, when a photoacoustic signal is generated from the target absorbing body having the multi-modal microbubble contrast agent injected thereinto as the result of absorbing a laser pulse applied to the target absorbing body, receiving the photoacoustic signal in order to acquire a photoacoustic image, applying a critical value to pixels corresponding to microbubbles in the ultrasonic image in order to generate a mask image, and removing a background noise generated from a non-target absorbing body, while maintaining the target absorbing body, from the photoacoustic image using the mask image.

Abstract: The present invention relates to a diagnosis system and method using a contrast agent used in photoacoustic image diagnosis and ultrasound image diagnosis. More particularly, the present invention relates to a diagnosis system and method using a photoacoustic/ultrasound contrast agent, the system and method discriminating and selectively detecting ultrasonic waves emitted from respective contrast agents by analyzing a correlation between a size of a contrast agent and a frequency of an ultrasonic wave emitted from the contrast agent, thereby obtaining a plurality of clear photoacoustic images.

Abstract: A washing machine and a method of controlling the washing machine are provided. In the washing machine and the method of controlling the washing machine, a liquid detergent is automatically supplied into a washing tub, thereby improving user convenience. In addition, in the washing machine and the method of controlling the washing machine, a liquid detergent is supplied into the washing tub by water circulated by a circulation unit. Thus, no liquid detergent remains in a liquid detergent supply path, and the liquid detergent supply path can be prevented from being blocked due to the solidification of a liquid detergent.

Abstract: An ultrasound diagnosis apparatus and a method of controlling the same are provided. The ultrasound diagnosis apparatus includes an ultrasound probe configured to transmit an ultrasound signal to an object and receive an ultrasound echo signal from the object to form a reception signal; a body configured to receive the reception signal from the ultrasound probe and process the reception signal; an impedance matching circuit configured to match an impedance of the ultrasound probe with an impedance of the body; and a controller configured to control the impedance matching circuit to operate as at least one filter that passes or rejects a signal of a specific frequency band, based on the impedance of the ultrasound probe, the impedance of the body, and relevant frequency characteristics of the reception signal.

Abstract: The present invention provides a dual-purpose photoacoustic tomography (PAT)/ultrasound contrast agent comprising: (a) a micro-bubble containing gas and porphyrin therein; and (b) nanoparticles bound on a surface of the micro-bubble and containing a drug. The contrast agent of the present invention can be used in both the ultrasound diagnosis and the photoacoustic image diagnosis, and can significantly increase the accuracy of photoacoustic images.

Abstract: The present invention relates to a method for producing an intravascular ultrasonic transducer and a structure for same, the method for producing a ultrasonic transducer producing a single element by: forming a piezoelectric element lapped according to a previously set thickness; depositing conductive material on the lapped surface of the piezoelectric element; forming a matched layer and a rear surface layer by casting the front and rear surfaces of the piezoelectric element to which conductive material has been deposited; lapping according to a previously set thickness; and dicing the bulk material, which is a stack of a matched layer, a piezoelectric element and a rear surface layer, along the stack direction so that the size of the element is less than the critical size for intravascular ultrasound (IVUS).

Abstract: Provided is a method for discriminating a tissue of interest and a method for generating photo-acoustic images to detect a calcified tissue, which includes: detecting an intensity of each pixel of a tissue-of-interest image obtained for each wavelength; matching an index corresponding to an image, which has a greatest intensity corresponding to each pixel, to each pixel; generating a signal weight corresponding to each pixel in consideration of a wavelength absorbed by the tissue of interest; and applying the generated signal weight of each pixel to each pixel of an image obtained with a wavelength, which is the most absorbed by the tissue of interest, to generate an image in which a background is discriminated.

Abstract: Various embodiments are described herein for a method, apparatus and system for performing multi-modal imaging using a common imaging probe having various modes of operation including a fluorescent (FL) imaging mode and at least one of an ultrasound (US) imaging mode, a photoacoustic (PA) imaging mode and a combined US/PA imaging mode. Molecular/functional information may be obtained from FL and PA imaging and anatomical information may be obtained from ultrasound (US) imaging. The system may be implemented to provide for images from each modality in real time as well as provide for co-registration of these images. Experimental results demonstrate that combining the imaging modalities does not significantly compromise the performance of each of the separate US, PA, and FL imaging techniques, while enabling multi-modality registration.

Abstract: Disclosed is a device and method for acquiring a fusion image, which applies an ultrasound signal for an ultrasound image, an optical signal for a photoacoustic image and a fluorescent image to a target, receives an ultrasound signal, a photoacoustic signal and an optical signal from the target, and generates a fusion image including image information with different probing planes with respect to the target by using at least two signals of the received ultrasound signal, the received photoacoustic signal and the received optical signal.

Abstract: An ultrasound diagnostic apparatus to improve picture quality of images by automatically adjusting image parameters, and a control method thereof are provided. The ultrasound diagnostic apparatus includes an image signal processor to perform envelope detection processing on ultrasound image data, and an image parameter processor to calculate a Time Gain Compensation (TGC) parameter from the envelope detection processed ultrasound image data, adjust the envelope detection processed ultrasound image data based on the TGC parameter, and calculate a Dynamic Range (DR) parameter from the envelope detection processed ultrasound image data adjusted based on the TGC parameter to apply the DR parameter to the envelope detection processed ultrasound image data.