Abstract: We have discovered p40, the shortest variant of a new human p53 homologue (p40/p51/p63/p73H). We have also found that it plays a role in cancer. Low level amplification of the p40 locus accompanied by RNA and protein overexpression was observed in primary lung cancers, and head and neck cancer cell lines. P40 protein overexpression in primary lung tumors was limited to squamous cell carcinoma, tumors known to harbor a high frequency of p53 mutations. Overexpression of p40 in Rat 1a cells led to an increase in soft agar growth and tumor size in mice. We searched for p40 binding proteins using the yeast two-hybrid system. P53 was the most common binding target of the 1.6×106 clones screened from a mouse embryonic library. Moreover, coexpression of p40 and p53 led to a decrease in p53 transcriptional activity. Our results support the notion that p40 plays an oncogenic role in human cancer.

Abstract: We have discovered p40, the shortest variant of a new human p53 homologue (p40/p51/p63/p73H). We have also found that it plays a role in cancer. Low level amplification of the p40 locus accompanied by RNA and protein overexpression was observed in primary lung cancers, and head and neck cancer cell lines. P40 protein overexpression in primary lung tumors was limited to squamous cell carcinoma, tumors known to harbor a high frequency of p53 mutations. Overexpression of p40 in Rat 1a cells led to an increase in soft agar growth and tumor size in mice. We searched for p40 binding proteins using the yeast two-hybrid system. P53 was the most common binding target of the 1.6×106 clones screened from a mouse embryonic library. Moreover, coexpression of p40 and p53 led to a decrease in p53 transcriptional activity. Our results support the notion that p40 plays an oncogenic role in human cancer.

Abstract: Over the past decade, it has become clear that tumorigenesis is driven by alterations in genes that control cell growth or cell death. Theoretically, the proteins encoded by these genes provide excellent tools for achieving tumor cell-specific expression. An approach to achieving specific expression of a desired protein in tumor cells is based on the selective expression of such oncoproteins. In outline, an endogenous cellular oncoprotein binds to exogenously introduced gene products, resulting in transcriptional activation of a desired gene. This approach is generally applicable to other diseases in which a particular protein is selectively expressed in disease-affected cells as compared to non-affected cells.

Abstract: An assembly of a notebook computer and a docking station includes a locking apparatus for locking the computer on the station. The apparatus includes a front retaining unit attached to the station and engaged within a front recess unit in the front end portion of the computer, and a rear retaining unit attached to the station and engaged within a rear recess unit in the rear end portion of the computer. In this situation, the computer is coupled completely with a connector unit on the station. Because the front and rear end portions of the computer are locked on the station by means of the retaining units which constitute a double lock, the computer cannot be removed forcibly from the station without disengaging the retaining units from the recess units.

Abstract: Over the past decade, it has become clear that tumorigenesis is driven by alterations in genes that control cell growth or cell death. Theoretically, the proteins encoded by these genes provide excellent tools for achieving tumor cell-specific expression. An approach to achieving specific expression of a desired protein in tumor cells is based on the selective expression of such oncoproteins. In outline, an endogenous cellular oncoprotein binds to exogenously introduced gene products, resulting in transcriptional activation of a desired gene. This approach is generally applicable to other diseases in which a particular protein is selectively expressed in disease-affected cells as compared to non-affected cells.

Abstract: A dock for connecting a notebook computer to a personal computer, having a casing having a top notebook computer bearing wall, a sliding block longitudinally moved in the casing, an actuating arm transversely fastened to the sliding block, and two guide mechanisms bilaterally disposed inside the casing and partially projecting out of the top notebook computer bearing wall of the casing for guiding the notebook computer into position, each guide mechanism including a guide block, a spring imparting a downward pulling force to the guide block and a pivoted push rod forced by the actuating arm to push the guide block out of the top notebook bearing wall for guiding the notebook computer into position, wherein when the notebook computer is loaded and moved into position, the sliding block is pushed forwards to move the actuating arm away from the pivoted push rods of the guide mechanisms, causing the guide blocks of the guide mechanisms to be pulled downwards from the top notebook bearing wall and received inside