Abstract: The present invention relates to a method for screening drug candidates for treating a disease using the interaction between calcium and phosphatidylinositol phosphate. Particularly in the present invention, it was confirmed that the concentration of calcium was increased in the obesity induced insulin resistance animal model and the increased calcium concentration inhibited the migration of Akt protein containing PH domain and the signal transduction, while the protein containing C2 domain was able to migrate to the cell membrane by binding to calcium/PIP complex even under the condition of high calcium concentration. Therefore, the investigation of the interaction between calcium and PIP can be a useful method for screening of drug candidates for treating metabolic disease, cancer or hypertension.

Abstract: The present disclosure proposes an adaptive non-speculative DFE with an extended time constraint for a PAM-4 receiver and a method for operating the same. An adaptive non-speculative DFE with an extended time constraint for a PAM-4 receiver according to the present disclosure comprises a Continuous-Time Linear Equalizer (CTLE) to boost high-frequency components of an input signal, a Track and Hold (T&H) circuit to track and hold an output of the CTLE, and a sampler, wherein the sampler includes a Decision Feedback Equalization (DFE) sampler to equalize an output of the T&H circuit and sample an output of the T&H circuit in a DFE sampling clock phase; and a DATA sampler to sample a signal equalized by the DFE sampler in a DATA sampling clock phase, wherein the DFE sampling clock phase differs from the DATA sampling clock phase.

Abstract: The present invention relates to a method for screening drug candidates for treating a disease using the interaction between calcium and phosphatidylinositol phosphate. Particularly in the present invention, it was confirmed that the concentration of calcium was increased in the obesity induced insulin resistance animal model and the increased calcium concentration inhibited the migration of Akt protein containing PH domain and the signal transduction, while the protein containing C2 domain was able to migrate to the cell membrane by binding to calcium/PIP complex even under the condition of high calcium concentration. Therefore, the investigation of the interaction between calcium and PIP can be a useful method for screening of drug candidates for treating metabolic disease, cancer or hypertension.

Abstract: The present invention relates to a fusion protein consisting of a C2 domain and an Akt protein fragment, particularly the fragment consisting of the amino acid residues ranging from the 111th to the 480th amino acids from the N-terminus of the Akt protein, and a use of the said fusion protein. More specifically, the fusion protein of the present invention increases the Akt protein activity even under the condition of high calcium concentration, reduces body weight and fat in an animal model treated with a high fat diet infected with adenovirus containing the fusion protein above, improves insulin resistance and improves fatty liver, so that the fusion protein comprising the C2 domain and the fragment consisting of the amino acid residues ranging from the 111th to 480th amino acids from the N-terminus of Akt protein can be effectively used for the treatment of metabolic disease.

Abstract: A recording/reproducing system for multiple users is disclosed which includes a plurality of channels connected to multiple users, a data processing portion for processing a signal of input/output information of an optical disk, and an optical head portion for reading and writing the information of optical disk. The optical head portion has at least one ultra-slim, subminiature multi-head device commonly having at least two optical heads, thereby allowing individuals to process desired information at any time.

Abstract: Apparatus is disclosed for providing an optical system which drives beam collecting lens by piezo device, for focusing the beam which moves according to the rotation of reflection mirror for using beam scanning that scans the laser beam on the surface of optical magnetic tape to be always set on the surface of the tape. An optical magnetic recording system modulates an image signal and converts the modulated signal to laser signal, and drives beam collecting lens (object lens) that collects the laser data by the synchronizing signal of the image signal, so as to allow optical magnetic recording on the tape surface. An optical recording system for recording by helical scanning the collected beam of the beam collecting lens on the tape surface using polysurface rotary mirror. An optical recording and playback system picks up optically recorded data on a optical magnetic tape using a contact sensor.

Abstract: There is disclosed a high resolution thermal printing device including a 128-bit uni-directional integrated circuit, which is specially ordered, instead of a general integrated circuit. The electrical connection of the device is achieved by wedge wire bonding employing wedges. The integrated circuit has a plurality of power source connecting pads which are aligned on the central portion the integrated circuit in parallel with the transverse direction thereof.