Abstract: A switching power supply circuit, a charging and discharging method, and a charging and discharging device are provided, relating to the technical field of power management. The switching power supply circuit includes a first node, a second node, a buck-boost conversion circuit coupled between the first node and the second node, an auxiliary conversion circuit, and a control circuit. The control circuit is configured to activate the buck-boost conversion circuit and/or a first auxiliary conversion circuit based on a first voltage at the first node and a second voltage at the second node.

Abstract: An off-road vehicle includes a prime mover assembly with a drive motor, and also includes a power battery, both positioned rearward of seating. When viewed from a length direction of the off-road vehicle, both the power battery and a rear cargo area at least partially overlap with the seating. When viewed from a height direction of the off-road vehicle, the rear cargo area at least partially overlaps with the power battery and the drive motor. The off-road vehicle further includes a back panel at least partially positioned between the power battery and the seating. The back panel has a maintenance opening defined therein for accessing the power battery.

Abstract: An automatic cat litter box includes a rotating drum mechanism. The rotating drum mechanism includes a rotating drum, a door assembly movably connected to the rotating drum, and a waste collection compartment. The door assembly includes a pressing portion. The waste collection compartment is disposed in the rotating drum. The waste collection compartment includes an opening portion. The opening portion is annular. When the door assembly is closed, the pressing portion is engaged with at least a portion of the opening portion. At this time, the pressing portion and the opening portion limit and support each other. The pressing portion limits a deformation of the opening portion, and the opening portion also limits a deformation of the pressing portion, thereby preventing cat litter leakage caused by deformations of the door assembly and the waste collection compartment.

Abstract: In one aspect, a transmission structure transmission structure comprises a rotating shaft and a transmission body, wherein one end of the rotating shaft is provided with a limiting track, and the other end of the rotating shaft is used for being connected to a driving mechanism; and one end of the transmission body movably matches the limiting track, so that the transmission body reciprocates along an axis of the rotating shaft under the limiting of the limiting track when the rotating shaft rotates, and the other end of the transmission body is used for being connected to an apparatus needing to do linear reciprocating work.

Abstract: A chip holding tool (12) comprises: a holding surface (24) for holding a semiconductor chip (100) in a non-contact manner; a suction path (33) for providing negative pressure at the holding surface (24) and drawing the semiconductor chip (100) by suction; and an ultrasonic generator (14) for providing ultrasonic oscillation to the holding surface (24), wherein the size of the outer shape of the holding surface (24) is larger than the size of the outer shape of the semiconductor chip (100). A positioning groove (36) having a shape conforming to at least a portion of the outer shape of the semiconductor chip (100) is formed in the holding surface (24).

Abstract: Disclosed is a compound capable of inhibiting interleukin 17A (IL-17A), which is represented by formula (I). An application of the compound or a stereoisomer thereof in the preparation of drugs for inhibiting IL-17A is also provided.

Abstract: A compound of formula (I): where X1 is C or N, X2 and X3 are independently O, N, NRX or CRX, X4 and X5 are independently C or N, L is —C2-6 alkylene or —C2-6 alkenylene, Z is C(O), S(O) or S(O)2, and Y1, Y2 and Y3 are each independently N or CRY. This application further provides an application of the compound of formula (I) or a stereoisomer thereof in the preparation of a drug for treating a IL-17A-related disease.

Abstract: The present invention discloses a differentially private computation method based on a shuffle model, belonging to the field of data security and personal information protection. The method comprises: constructing a personalized shuffle model; optimizing the data randomization performance of the personalized shuffle model by using a randomization mechanism optimized for non-statistical tasks to obtain an improved personalized shuffle model; and using the improved personalized shuffle model to perform encryption and decryption on user input data. The invention enables personalized outputs while maintaining privacy and benefiting from the privacy amplification effect of the shuffle model. Through an innovative combination of encryption and anonymization, the invention addresses the long-standing challenges of privacy protection in non-statistical tasks and demonstrates broad applicability.

Abstract: The invention relates to RNA molecules encoding an E. coli fimbrial H antigen (FimH). The present disclosure further relates to compositions comprising the RNA molecules formulated in a lipid nanoparticle (RNA-LNP). The present disclosure further relates to the use of the RNA 5 molecules, RNA-LNPs and compositions for the prevention of E. coli infection, including urinary tract infection.

Abstract: Provided is an anti-PD-L1 antigen binding protein, capable of binding to primate-derived PD-L1 with a KD value of 1×10?8 M or less. The antigen binding protein can block the binding of PD-1 and CD80 to PD-L1, stimulate the secretion of cytokines in immune cells, and can inhibit tumor growth and/or tumor cell proliferation. Also provided is a fusion protein, comprising human TGFBRII or a fragment thereof and the antigen binding protein. Also provided is an application of the antigen binding protein and/or the fusion protein in the prevention and treatment of tumors or cancers.

Abstract: Provided herein are small interfering ribonucleic acid (siRNA) agents targeting a microtubule-associated protein tau (MAPT) gene and compositions comprising such siRNA agents.

Abstract: A sample analysis system, method and a cell image analysis device. The sample analysis system includes a blood cell analyzer, a smear preparation apparatus, a cell image analysis apparatus, and a controller. The controller obtains a test result of at least one sample from the blood cell analyzer. When one sample needs to be analyzed by the cell image analysis device, the controller can further control an imaging condition used by the cell image analysis device according to a value of at least one type of cells in the test result of the sample, such that the cell image analysis device can automatically selects an imaging condition matching the test result for imaging according to different test results of the sample. Therefore, a matching imaging condition is used to specifically capture and analyze cell images of a smear of the sample, thereby improving processing efficiency and accuracy.

Abstract: A method and device for the detection of short to ground circuits is disclosed. The method includes (i) connecting to a detection current source that is linked to the high-side lead terminal of the two lead terminals of an electronic control circuit, (ii) disconnecting the low-side switch of the ground terminal of the electronic control circuit, (iii) measuring the voltage of the two lead terminals of the electronic control circuit separately, and (iv) determining whether the high-side lead terminal or the low-side lead terminal of the two lead terminals has a short to ground circuit by comparing the voltages of the two lead terminals. When the voltage of the high-side lead terminal is greater than the voltage of the low-side lead terminal, it is determined that the low-side lead terminal has a short to ground circuit. When the voltage of the high-side lead terminal is equal to the voltage of the low-side lead terminal, it is determined that the high-side lead terminal has a short to ground circuit.

Abstract: The present invention provides a compound as shown in formula I, having a binding effect with E3 ligase protein CRBN, and a use of the compound in the preparation of a medicine for treating abnormal cell proliferation diseases.

Abstract: A process for preparing a zeolite having a CHA-type framework structure comprising X2O3 and YO2, wherein X is a trivalent element and Y is a tetravalent element, which includes (1) preparing a synthesis mixture comprising (A) a source for X2O3, (B) a source for YO2, and (C) a source for an organic structure directing agent (OSDA) comprising a diquaternary ammonium cation of formula (I) or a combination of diquaternary ammonium cations of formula (R1R2R3)N+(CH2)nN+(R4R5R6) (I) as defined in claims and (2) subjecting the synthesis mixture to crystallization conditions to form a zeolite having a CHA-type framework structure. The present invention also relates to the zeolite having a CHA-type framework structure obtained from the process and use of the zeolite in catalysts for selective catalytic reduction of nitrogen oxides.

Abstract: An alignment method for a first semiconductor chip (221) and a second semiconductor chip (231) to be stacked, wherein the first semiconductor chip (221) is ultrasonically vibrated, a lower surface (231a) of the second semiconductor chip (231) is brought close to an upper surface (221a) of the first semiconductor chip (221) so as to overlap the first semiconductor chip (221) that is vibrating ultrasonically and the second semiconductor chip (231) is released to self-align the second semiconductor chip (231) on the first semiconductor chip (221).

Abstract: A fog dissipation device includes a first flow path and a second flow path which are stacked to exchange heat between a first air flow and a second air flow flowing from bottom to top; a first outflow port through which the first air flow flowing out of the first flow path is discharged to the upper side of the fog dissipation device; and a second outflow port through which the second air flow flowing out of the second flow path is discharged to the upper side of the fog dissipation device, wherein the first outflow port and the second outflow port are alternately stacked. The fog dissipation device can play a role in water-saving fog dissipation.