Abstract: Disclosed herein are compounds capable of modulating GPR17 and pharmaceutical compositions of such compounds and methods of treatment for conditions, e.g., neurodegenerative diseases or demyelinating diseases, using such pharmaceutical compositions.

Abstract: A universal contact center service access point is mapped to a service access point specific to a determined modality to establish a connection between a user device and a contact center operator device and associated with that modality. A request for a contact center engagement is obtained from a user device, in which the request includes a universal contact center service access point. Responsive to the request, the universal contact center service access point is mapped, based on a record associating multiple modalities with the universal contact center service access point, to a service access point specific to one of those multiple modalities determined based on information associated with the user device. The contact center engagement is then facilitated over a connection, established based on the mapping, between the user device and a contact center operator device associated with the service access point.

Abstract: A cardiac-targeting extracellular vesicle (EV), an EV for treating cardiovascular disease, and method of preparation and use thereof are provided. The EV contains a fusion sequence of Lamp-2b and peptide targeting cardiacmyocytes, CMP. It has been discovered that the cardiac-targeting EV exhibits the ability to specifically target the heart, thereby serving as a novel delivery tool system for cardiac-targeting therapy. The cardiac-targeting EV is loaded with miR-30d to obtain an EV for treating the cardiovascular disease, which demonstrates significant therapeutic effects on conditions such as cardiac ischemia-reperfusion injury and myocardial hypertrophy. This provides a new therapeutic approach for the clinical treatment of cardiovascular diseases. Additionally, targeted delivery of therapeutic agents using the cardiac-targeting EV is achieved, enabling effective prevention and treatment of cardiac diseases.

Abstract: In some aspects, a method, a system, or a non-transitory computer-readable storage medium are described for training one or more models to predict ulcerative colitis (UC) severity based on human-interpretable image features extracted from a whole-slide image, including acts of accessing a plurality of annotated whole-slide images associated with a plurality of UC patients, wherein each of the plurality of annotated whole-slide images includes at least one annotation describing a cell-type label or a tissue-type segmentation for a portion of the whole-slide image, extracting a plurality of human-interpretable image features based on cell-type labels and tissue-type segmentations associated with the plurality of annotated whole-slide images, training a statistical model based on the plurality of human-interpretable image features to predict the UC severity for a whole-slide image, and storing the trained model on at least one storage device.

Abstract: Provided is an anti-PD-L1 antigen binding protein, capable of binding to primate-derived PD-L1 with a KD value of 1×10?8 M or less. The antigen binding protein can block the binding of PD-1 and CD80 to PD-L1, stimulate the secretion of cytokines in immune cells, and can inhibit tumor growth and/or tumor cell proliferation. Also provided is a fusion protein, comprising human TGFBRII or a fragment thereof and the antigen binding protein. Also provided is an application of the antigen binding protein and/or the fusion protein in the prevention and treatment of tumors or cancers.

Abstract: The present application provides a surface covering product comprising a surface ornamental layer, a buffer layer, a supporting layer, and a backing layer. The surface ornamental layer has a top surface and a bottom surface. The buffer layer is made from a porous material with a top surface and a bottom surface. The supporting layer is made from a foamed polymeric material with a top surface and a bottom surface. The backing layer has a top surface and a bottom surface. The bottom surface of the surface ornamental layer is attached to the upper surface of the buffer layer, the bottom surface of the buffer layer is attached to the top surface of the supporting layer, and the bottom surface of the supporting layer is attached to the top surface of the backing layer.

Abstract: An air purifier is disclosed, comprising a base and a hair collection bin disposed near the bottom of the base. The base is provided with a mounting cavity and an opening in communication with the mounting cavity, and the hair collection bin is slidably disposed within the mounting cavity through the opening. The hair collection bin is provided with a first air inlet and a hair collection chamber in communication with the first air inlet and the mounting cavity. The base is provided with at least one second air inlet in communication with the hair collection chamber. By arranging the hair collection bin near the bottom of the base, disposing the first air inlet and second air inlet in the bottom of the base, a high-efficiency capture of ground hair, dander and other debris by the air purifier is achieved.

Abstract: An automatic cat litter box includes a rotating drum mechanism. The rotating drum mechanism includes a rotating drum, a door assembly movably connected to the rotating drum, and a waste collection compartment. The door assembly includes a pressing portion. The waste collection compartment is disposed in the rotating drum. The waste collection compartment includes an opening portion. The opening portion is annular. When the door assembly is closed, the pressing portion is engaged with at least a portion of the opening portion. At this time, the pressing portion and the opening portion limit and support each other. The pressing portion limits a deformation of the opening portion, and the opening portion also limits a deformation of the pressing portion, thereby preventing cat litter leakage caused by deformations of the door assembly and the waste collection compartment.

Abstract: The present disclosure provides an automatic pet litter adding device, comprising: a pet litter cabin, a support plate, a pet litter adding component, a motor assembly; wherein: the bottom of the pet litter cabin is provided with a first pet litter outlet; the support plate is provided with a pet litter dividing trough, the bottom of the pet litter dividing trough is provided with a second pet litter outlet, the pet litter adding component is rotatably arranged in the pet litter dividing trough. When the pet litter adding component rotates, the cat litter in the pet litter cabin slides to the pet litter dividing area. The cat litter in the pet litter dividing area is pushed to the second pet litter outlet, and slides from the second pet litter outlet to the designated area.

Abstract: A cat litter box includes a base, a driver, and a drum assembly. The driver drives the drum assembly to rotate. The drum assembly includes a drum body and a partition assembly. The partition assembly includes a partition plate, a little guide plate, a litter sieve, and an emptying plate. The partition assembly divides an accommodating cavity into a first cavity and a second cavity. The first cavity is configured to accommodate a pet. A waste collecting compartment and a little collecting compartment are defined in the second cavity. The litter sieve is a litter inlet of the little collecting compartment. The little guide plate is movable relative to the partition plate to communicate the first cavity with the waste collecting compartment. The little guide plate is a door of an waste inlet of the waste collecting compartment. The emptying plate is configured to cover the litter sieve.

Abstract: Disclosed herein is a compound of formula (I). An application of the compound of formula (I) or a stereoisomer thereof in the preparation of a drug for inhibiting interleukin-17A (IL-17A) is further provided.

Abstract: A system for loading dynamic stress on subgrade or foundation based on multi-servo channel and a control method thereof. The system comprises: connecting plate; five dynamic actuators are hinged between connecting frame and the connecting plate; four of them form 4-RPR parallel mechanism, another one is arranged in middle of the 4-RPR parallel mechanism; loading part is mounted at center under the connecting frame; and restraining plate is arranged under the loading part and freely contacts with the loading part; four static actuators are arranged between the restraining plate and the connecting plate; wherein, the static actuators and dynamic actuators are dynamic-static cooperative controlled through multi-servo channel, to simulate principal stress axes rotation effect of a soil body of subgrade or foundation The system can realize the principal stress axes rotation effect in the subgrade or foundation through dynamic-static cooperative loading and can simulate different traffic load forms.

Abstract: A geogrid prepared by recycling medical waste and a preparation method therefor, and use in foundation reinforcement. The method includes: recycling medical waste for treatment and processing the medical waste into a crushed material; adding modified filler and processing aids, and selecting high-strength fiber bundles for compounding and melting with the crushed material and pressing and stretching to prepare a geogrid. The medical waste is any combination of one or more used medical plastic products and medical plastic products that expire and are not used. The high-strength fiber bundles are more than one bundle of fiber materials commonly used for manufacturing geogrids on the market. The modified filler is a stabilizer for improving the stability of component materials to heat and light. The processing aids are enhancers for improving the performance of the component materials.

Abstract: A sample analysis system, method and a cell image analysis device. The sample analysis system includes a blood cell analyzer, a smear preparation apparatus, a cell image analysis apparatus, and a controller. The controller obtains a test result of at least one sample from the blood cell analyzer. When one sample needs to be analyzed by the cell image analysis device, the controller can further control an imaging condition used by the cell image analysis device according to a value of at least one type of cells in the test result of the sample, such that the cell image analysis device can automatically selects an imaging condition matching the test result for imaging according to different test results of the sample. Therefore, a matching imaging condition is used to specifically capture and analyze cell images of a smear of the sample, thereby improving processing efficiency and accuracy.

Abstract: Disclosed is a coordinated peak shaving optimization method for a plurality of power supplies based on a fluctuation characteristic of a renewable energy source, including the following steps: s1: determining a weekly generated electricity quantity of hydropower based on an available capacity and a storage capacity of an electricity quantity; s2: predicting a renewable energy power generation curve and a load curve of a system weekly; s3: determining a start point of peak shaving of the hydropower based on an external transmission curve, the renewable energy generation curve, and the load curve of the system and a generating capacity of the hydropower; s4: determining a weekly peak shaving demand of the system; and s5: establishing an optimization model with a maximum peak shaving demand. The present disclosure proposes a reasonable arrangement for peak shaving, so as to resolve an accommodation problem caused by large-scale access of a renewable energy source.

Abstract: A dust collection and filtration device includes: a housing forming a cavity, the housing defining a mounting port, an intake port, and an exhaust port; a hollow inner housing assembly arranged within the cavity and dividing the cavity into a first chamber and a second chamber; the inner housing assembly defining a first communication port and a second communication port; the inner housing assembly being in communication with the first chamber through the first communication port, and in communication with the second chamber through the second communication port; the intake port being in communication with the first chamber, and the mounting port and the exhaust port both being in communication with the second chamber; a first filtration structure arranged within the inner housing assembly; a second filtration structure connected to the inner housing assembly; and a third filtration structure arranged at the mounting port.

Abstract: Consistency metadata, including a parameter for a pseudo-random number source, are determined for training-and-evaluation iterations of a machine learning model. Using the metadata, a first training set comprising records of at least a first chunk is identified from a plurality of chunks of a data set. The first training set is used to train a machine learning model during a first training-and-evaluation iteration. A first test set comprising records of at least a second chunk is identified using the metadata, and is used to evaluate the model during the first training-and-evaluation iteration.