Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for dynamically managing webpage traffic. In some implementations, a server receives a request from a client device to access a webpage. The server obtains attributes associated with the client device that provided the request. The server selects one or more webpage variants using the request. Data associated with the request and with the one or more webpage variants are provided as input to a trained machine learning model. The server obtains output from the machine learning model that indicates the likelihood for each webpage variant that the user will access a particular feature of the corresponding webpage variant. The server provides data representing the webpage variant of the one or more webpage variants whose likelihood satisfies a threshold value.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating webpage data. An example method includes accessing content data associated with a first webpage and determining context data corresponding to one or more users associated with the first webpage. Based on (i) the content data and (ii) the context data, prompt data for one or more trained machine learning (ML) models is generated. The prompt data is provided to the ML models to obtain output data corresponding to one or more variation content elements. Data representing one or more candidate webpages is generated by adapting the one or more variation content elements according to the content schema. An instruction is provided to a computing device to cause the display of a representation of at least one candidate webpage included in the one or more candidate webpages.

Abstract: Provided herein are methods for purifying an ionizable amino lipid (IAL) composition comprising impurities that may react with polynucleotides, such as mRNA. Methods for purifying IAL compositions comprise one or more scavenging-removal steps to selectively remove reactive impurities.

Abstract: The present disclosure is based, at least in part, on the discovery that high-purity PEG lipids exhibit superior physical and biological properties, particularly when used in lipid nanoparticle (LNP) formulations. Therefore, the present disclosure provides PEG lipids at a recommended purity, e.g., for use in formulations, such as LNP formulations. The present disclosure also provides LNPs comprising the high-purity PEG lipids, and methods for delivering therapeutic agents to a subject using the same.

Abstract: The present disclosure is based, at least in part, on the discovery that high-purity PEG lipids exhibit superior physical and biological properties, particularly when used in lipid nanoparticle (LNP) formulations. Therefore, the present disclosure provides PEG lipids at a recommended purity, e.g., for use in formulations, such as LNP formulations. The present disclosure also provides LNPs comprising the high-purity PEG lipids, and methods for delivering therapeutic agents to a subject using the same.

Abstract: The present disclosure is based, at least in part, on the discovery that high-purity PEG lipids exhibit superior physical and biological properties, particularly when used in lipid nanoparticle (LNP) formulations. Therefore, the present disclosure provides PEG lipids at a recommended purity, e.g., for use in formulations, such as LNP formulations. The present disclosure also provides LNPs comprising the high-purity PEG lipids, and methods for delivering therapeutic agents to a subject using the same.

Abstract: The invention relates to sterol esters and methods for producing purified sterols that can be utilized in methods for producing a lipid nanoparticle.

Abstract: Embodiments of the present teachings disclose method, system, and programs for a multi-phase ranking system for implementation with a personalized content system. The disclosed method, system, and programs utilize a weighted AND system to compute a dot product of the user profile and a content profile in a first phase, a content quality indicator in the second phase and a rules filter in a third phase.

Abstract: Embodiments of the present teachings disclose method, system, and programs for a multi-phase ranking system for implementation with a personalized content system. The disclosed method, system, and programs utilize a weighted AND system to compute a dot product of the user profile and a content profile in a first phase, a content quality indicator in the second phase and a rules filter in a third phase.

Abstract: Provided is a navigation system having a path search function based on number of intersections and a method thereof. The system includes a Global Positioning System (GPS) module for receiving each position signal, and calculating a self position; a map DataBase (DB) for storing map data including information on a road and an intersection of the road; a storage unit for storing at least two searched paths and number of intersections; and a controller for searching the map data for at least two possible paths from a current position to a destination, storing the searched paths in the storage unit, counting the number of intersections, selecting the path having the least counted number of intersections, and mapping the selected path to the map data.

Abstract: In one embodiment, a method includes periodically collecting device operation data from a plurality of client devices of a distributed computing system, and making power management decisions for the distributed computing system based on the collected data.

Abstract: A method and an apparatus of evaporative cooling for reducing the volume of an evaporative cooler by considerably lowering the temperature of a cooling fluid are disclosed. A first cooling fluid, which comprises most part of the cooling fluid evaporatively cooled by an outside air while passing through an evaporative cooling section after circulating in an apparatus to be cooled, re-circulates in the apparatus to be cooled. A second cooling fluid, which is separated from the cooling fluid after being cooled in the evaporative cooling section, passes through a sensible air-cooling section placed at an outside air inlet. Thereby, the inflow outside air is sensibly cooled. The second cooling fluid, which passes through the sensible cooling section, re-circulates in the evaporative cooling section. Also, the outside air that is sensibly cooled by the second cooling fluid evaporatively cools the cooling fluid, which passes through the evaporative cooling section, again. This process is repeated.

Abstract: A television receiver and method of displaying and editing images in an electronic photo album are disclosed. The television receiver includes an interface means reading a plurality of still images and additional information corresponding to the still images, wherein the still images are stored in an external device, a central processing unit displaying a window including a sub-picture for searching the still images, and a main picture for displaying a still image selected from the sub-picture, and a memory for storing the read additional information.