Abstract: The invention provides isolated nucleic acid and amino acid sequences of novel receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of the receptors.

Abstract: This invention provides a new electroluminescent conjugated polymers grafted with highly efficient phosphorescent organometallic complexes (such as iridium, platinum, osmium, rubidium, etc.) and charge transport moieties (such as oxadiazole, thiadiazole, triazole, pyridine, pyrimidine, substituted or non-substituted tertiary arylamines, substituted or non-substituted quarternary arylammonium salts, substituted or non-substituted tertiary heterocyclic aromatic amines, substituted or non-substituted quarternary heterocyclic aromatic ammonium, etc.). The emissive polymers (fully conjugated or limited conjugating length) covering the full visible range can be prepared. The polymeric light emitting diodes with these materials can be used as indicators, light source and display for cellular phones, digital camera, pager, portable computer, personal data acquisition (PDA), watch, hand-held videogame, billboard, etc.

Abstract: A snap block structure for racing type bicycle shoes includes a hard snapping plate, and a soft anti-skid pad mounted on the snapping plate. Thus, the snap block structure has an anti-skid pad mounted on the snapping plate to provide an anti-skid effect when touching the ground. In addition, the anti-skid pad is combined with the snapping plate rigidly and stably, thereby enhancing the strength of the snap block structure.

Abstract: A pedal assembly for a bicycle includes a pedal body, a pivot seat, and a bearing. The pedal body has a side provided with a pivot seat for mounting a single bearing, so that the position of the axial center of the pivot seat can be changed to reduce the distance between the force applying point of the user's foot and the axial center of the pedal body greatly. Thus, the force applying point of the user's foot is closer to the axial center of the pedal body, so that the rotation radius of the pedal body is closer to that of the crank of the bicycle, thereby saving the manual work and decreasing the centrifugal effect.

Abstract: The invention provides natural ligands of TGR183 receptors and methods of identifying modulators of various TGR183 receptors using the ligands. Methods of using the modulators to treat diseases or disorders associated with dysfunction of the TGR183 receptor are also provided.

Abstract: A snap block structure for a pair of mountaineering bicycle shoes each having a bottom formed with two protruding spiked blocks and two threaded locking holes located between the two spiked blocks. The snap block structure includes a snapping member mounted on the bottom of each of the mountaineering bicycle shoes and having a top face integrally formed with a protruding block mounted between the two spiked blocks of each of the mountaineering bicycle shoes. Thus, the mountaineering bicycle shoes are available for a mountaineering bicycle pedal and also available for the road-use bicycle pedal by provision of the snap block structure, thereby enhancing the versatility of the mountaineering bicycle shoes.

Abstract: Modulators of PPAR? activity are used in methods of treating and/or preventing conditions such as osteoporosis, Alzheimer's disease, psoriasis and acne, and cancer.

Abstract: The invention provides isolated nucleic acid and amino acid sequences of novel receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of the receptors.

Abstract: This invention provides a new electroluminescent conjugated polymers grafted with highly efficient phosphorescent organometallic complexes (such as iridium, platinum, osmium, rubidium, etc.) and charge transport moieties (such as oxadiazole, thiadiazole, triazole, pyridine, pyrimidine, substituted or non-substituted tertiary arylamines, substituted or non-substituted quarternary arylammonium salts, substituted or non-substituted tertiary heterocyclic aromatic amines, substituted or non-substituted quarternary heterocyclic aromatic ammonium, etc.). The emissive polymers (fully conjugated or limited conjugating length) covering the full visible range can be prepared. The polymeric light emitting diodes with these materials can be used as indicators, light source and display for cellular phones, digital camera, pager, portable computer, personal data acquisition (PDA), watch, hand-held videogame, billboard, etc.

Abstract: The invention provides methods and compositions for screening for pharmacological agents which regulate gene expression in mammals. An exemplary assay involves (a) contacting a mammalian cell comprising a knock-in mutant of a targeted native allele encoding a reporter of gene expression, wherein the expression of the reporter is under the control of the gene expression regulatory sequences of the native allele, with a candidate agent under conditions whereby but for the presence of the agent, the reporter is expressed at a first expression level; and, (b) measuring the expression of the reporter to obtain a second expression level, wherein a difference between the first and second expression levels indicates that the candidate agent modulates gene expression.

Abstract: Methods for identifying modulators of nuclear hormone receptor function comprise the steps of (a) forming a mixture comprising a nuclear hormone receptor, a peptide sensor and a candidate agent, but not a natural coactivator protein of the receptor, wherein the sensor provides direct, in vitro binding to the receptor under assay conditions; (b) measuring an agent-biased binding of the sensor to the receptor; and (c) comparing the agent-biased binding with a corresponding unbiased binding of the sensor to the receptor. In particular embodiments, the sensor comprises an amphipathic alpha helix nuclear hormone interacting domain comprising a recited nuclear hormone transcriptional coactivator motif sequence, the sensor is present at sub-micromolar concentration, the binding reaction occurs in solution, the sensor comprises a fluorescent label and the measuring step comprises detecting fluorescence polarization of the label.

Abstract: This invention provides a new electroluminescent conjugated polymers grafted with highly efficient phosphorescent organometallic complexes (such as iridium, platinum, osmium, rubidium, etc.) and charge transport moieties (such as oxadiazole, thiadiazole, triazole, pyridine, pyrimidine, substituted or non-substituted tertiary arylamines, substituted or non-substituted quarternary arylammonium salts, substituted or non-substituted tertiary heterocyclic aromatic amines, substituted or non-substituted quarternary heterocyclic aromatic ammonium, etc.). The emissive polymers (fully conjugated or limited conjugating length) covering the full visible range can be prepared. The polymeric light emitting diodes with these materials can be used as indicators, light source and display for cellular phones, digital camera, pager, portable computer, personal data acquisition (PDA), watch, hand-held videogame, billboard, etc.

Abstract: A housing mechanism (8) includes a housing (1) and a defending element (3). The housing has a cavity (11), thereby defining a sidewall. The sidewall of the housing defines an opening (2) therethrough. The opening communicates with the cavity. The defending element is located at the opening, and includes a door pivotable for covering or uncovering the opening.

Abstract: The invention provides natural ligands of various receptors and methods of identifying modulators of various receptors using the ligands. Methods of using the modulators to treat diseases or disorder associated with dysfunction of the receptor are also provided.

Abstract: A cable bracket for a bicycle has a frame and a resilient fastener. The frame is preferably Y-shaped and has a body with a looped end and two branched ends. The looped end has a cable recess for holding at least one cable. Each branched end has a hook for receiving the resilient fastener. When the two branched ends embrace a tube of the bicycle at a proper position, the resilient fastener has two ends secured on the hooks to make the frame attach on the tube firmly. Thereby, the cable bracket is detachably mounted on the tube. Moreover, the looped end only keeps the cable within the cable recess and does not constrict the cable so that the cable is kept in its original form without deformation or disturbance in operation.

Abstract: A racing type pedal includes a main body, a pivot hook, a limit member, an adjusting bolt, a press block, and two torsion springs. Thus, the movement of the adjusting bolt is limited by the limit member, and the movement of the press block is limited by the torsion springs, so that the adjusting bolt and the press block form a linear movement without deflection, thereby producing an evenly distributed shearing stress between the adjusting bolt and the press block, thereby preventing the adjusting bolt and the press block from being worn out due to an uneven shearing stress.

Abstract: A racing type pedal includes a main body, a pivot hook, a limit member, an adjusting bolt, a press block, and two torsion springs. Thus, the movement of the adjusting bolt is limited by the limit member, and the movement of the press block is limited by the torsion springs, so that the adjusting bolt and the press block form a linear movement without deflection, thereby producing an evenly distributed shearing stress between the adjusting bolt and the press block, thereby preventing the adjusting bolt and the press block from being worn out due to an uneven shearing stress.

Abstract: The present invention provides pharmaceutical compositions and methods for the treatment of diabetes mellitus using combination therapy. The compositions relate to a compound of Formula I and an antidiabetic agent such as sulfonylureas, biguanides, glitazones, ?-glucosidase inhibitors, potassium channel antagonists, aldose reductase inhibitors, glucagon antagonists, activators of RXR, insulin therapy or other anti-obesity agent. The methods include the administration of the combination of compound of Formula I with antidiabetic agent where the two components are delivered in a simultaneous manner, where the compound of Formula I is administered first, followed by the antidiabetic agent, as well as wherein the antidiabetic agent is delivered first followed by the compound of Formula I.

Abstract: A snap block structure for a pair of mountaineering bicycle shoes each having a bottom formed with two protruding spiked blocks and two threaded locking holes located between the two spiked blocks. The snap block structure includes a snapping member mounted on the bottom of each of the mountaineering bicycle shoes and having a top face integrally formed with a protruding block mounted between the two spiked blocks of each of the mountaineering bicycle shoes. Thus, the mountaineering bicycle shoes are available for a mountaineering bicycle pedal and also available for the road-use bicycle pedal by provision of the snap block structure, thereby enhancing the versatility of the mountaineering bicycle shoes.

Abstract: A cushion includes a flexible curved main body having a first end formed with a fixed portion and a second end formed with a movable portion, and an elastic mechanism mounted on the main body and biased between the fixed portion and the movable portion of the main body. Thus, the elastic mechanism is stretched by the movable portion of the main body to mate with variation of the curvature of the main body, so that when the main body is pressed and deformed by the user's weight, the main body has a greater elastic action, and the curvature of the main body is changed automatically by the elastic force of the elastic mechanism so as to fit users of different statures and weights.