Abstract: Disclosed are an application of a coronavirus SARS-CoV-2 vaccine polypeptide, a polypeptide composition and a nanoemulsion preparation thereof in the prevention of coronavirus SARS-CoV-2 wild and mutant strain infections. Specifically, provided is a coronavirus SARS-CoV-2 vaccine polypeptide having an amino acid sequence derived from an S protein of SARS-CoV-2 wild and mutant strains, the vaccine polypeptide can enable the body to generate high-level and durable humoral immune responses against SARS-CoV-2 and to produce high titers of RBD-binding antibodies and neutralizing antibodies that block the binding of RBD to ACE2. The vaccine polypeptide can be used to prevent infections of SARS-CoV-2 wild strain and B.1.1.7, B.1.351, B.1.617, B.1.1.529 and other mutant strains.

Abstract: The present invention relates to a novel coronavirus vaccine using a TLR7 agonist conjugated peptide as an antigen and an emulsion as an adjuvant. An antigen polypeptide of the conjugated peptide is a polypeptide derived from an S protein of SARS-COV-2, and the adjuvant is an oil-in-water nanoemulsion containing squalene. The conjugated peptide nanoemulsion vaccine preparation of the present invention is thermally stable, and can induce a high level of protective humoral immune response in a cynomolgus monkey, and the neutralizing antibody titer of antiserum after immunization of cynomolgus monkey is high, such that invasion of wild-type strain and mutant novel coronavirus can be blocked. The vaccine of the present invention has a nearly complete protection effect on the upper and lower respiratory tracts of the cynomolgus monkey in a cynomolgus monkey SARS-COV-2 challenge test.

Abstract: Provided are a tandem epitope polypeptide vaccine for novel coronavirus and use thereof. Specifically, a vaccine polypeptide for novel coronavirus pneumonia is provided on the basis of analysis and study of the RBD sequence and structural information of the S protein of SARS-CoV-2. Said vaccine polypeptide comprises the following elements connected in series: a generic Th epitope sequence, a B cell epitope sequence and a T cell epitope sequence. The B cell epitope and the T cell epitope have an amino acid sequence from the RBM region of the S protein of SARS-CoV-2. Provided are a vaccine composition containing said vaccine polypeptide and use thereof. Experiments show that the vaccine polypeptide of the present invention can enable cynomolgus monkeys to initiate strong cellular and humoral immunity, and to generate neutralizing antibodies that block the binding of RBD and ACE2, and can be used for preventing and treating novel coronavirus pneumonia.

Abstract: Disclosed are a polypeptide vaccine coupled with a TLR7 agonist for novel coronavirus and the use thereof. Specifically, the present invention provides a vaccine polypeptide for novel coronavirus pneumonia based on the basis of the analytical study of the RBD sequence and structural information of the S protein of SARS-CoV-2, wherein the vaccine polypeptide has the following structural formula: Z-(J-U)n, where in the formula, Z, J, U, n, etc. are as defined in the description. Also provided in the present invention are a vaccine composition containing the vaccine polypeptide and the use thereof.

Abstract: The present disclosure relates to systems, methods, and computer program products for keeping multiple caches updated, or coherent, on multiple servers when the multiple caches contain independent copies of cached data. Example methods may include receiving a request to write data to a block of a first cache associated with a first server in a clustered server environment. The methods may also include identifying a second cache storing a copy of the block, where the second cache is associated with a second server in the clustered environment. The methods may further include transmitting a request to update the second cache with the received write data, and upon receiving a subsequent request to write subsequent data, identifying a third cache for invalidating based on access patterns of the blocks, where the third cache is associated with a third server in the clustered environment.

Abstract: A device or system includes a plurality of storage resources each associated with a respective performance class, each being associated with selected performance characteristics such as IOPS, bandwidth, etc. The device or system includes a compute instance having access to allocated storage resources, the allocated storage devices including one or more storage resources. The device or system also includes an optimization component adapted to obtain information relating to utilization by the compute instance component of the allocated storage resources, determine that a change to the allocated storage resources is necessary, based on the information, cause data to be migrated from a first storage resource associated with a first performance class to a second storage resource associated with a second storage class, and cause a removal from the allocated storage resources of the first storage resource and an addition to the allocated storage resources of the second storage resource.

Abstract: A data storage caching architecture supports using native local memory such as host-based RAM, and if available, Solid State Disk (SSD) memory for storing pre-cache delta-compression based delta, reference, and independent data by exploiting content locality, temporal locality, and spatial locality of data accesses to primary (e.g. disk-based) storage. The architecture makes excellent use of the physical properties of the different types of memory available (fast r/w RAM, low cost fast read SSD, etc) by applying algorithms to determine what types of data to store in each type of memory. Algorithms include similarity detection, delta compression, least popularly used cache management, conservative insertion and promotion cache replacement, and the like.

Abstract: A device or system includes a plurality of storage resources each associated with a respective performance class, each being associated with selected performance characteristics such as IOPS, bandwidth, etc. The device or system includes a compute instance having access to allocated storage resources, the allocated storage devices including one or more storage resources. The device or system also includes an optimization component adapted to obtain information relating to utilization by the compute instance component of the allocated storage resources, determine that a change to the allocated storage resources is necessary, based on the information, cause data to be migrated from a first storage resource associated with a first performance class to a second storage resource associated with a second storage class, and cause a removal from the allocated storage resources of the first storage resource and an addition to the allocated storage resources of the second storage resource.

Abstract: The present disclosure relates to systems, methods, and computer program products for keeping multiple caches updated, or coherent, on multiple servers when the multiple caches contain independent copies of cached data. Example methods may include receiving a request to write data to a block of a first cache associated with a first server in a clustered server environment. The methods may also include identifying a second cache storing a copy of the block, where the second cache is associated with a second server in the clustered environment. The methods may further include transmitting a request to update the second cache with the received write data, and upon receiving a subsequent request to write subsequent data, identifying a third cache for invalidating based on access patterns of the blocks, where the third cache is associated with a third server in the clustered environment.

Abstract: The present disclosure relates to systems, methods, and computer program products for keeping multiple caches updated, or coherent, on multiple servers when the multiple caches contain independent copies of cached data. Example methods may include receiving a request to write data to a block of a first cache associated with a first server in a clustered server environment. The methods may also include identifying a second cache storing a copy of the block, where the second cache is associated with a second server in the clustered environment. The methods may further include transmitting a request to update the second cache with the received write data, and upon receiving a subsequent request to write subsequent data, identifying a third cache for invalidating based on access patterns of the blocks, where the third cache is associated with a third server in the clustered environment.

Abstract: The present disclosure relates to systems, methods, and computer program products for keeping multiple caches updated, or coherent, on multiple servers when the multiple caches contain independent copies of cached data. Example methods may include receiving a request to write data to a block of a first cache associated with a first server in a clustered server environment. The methods may also include identifying a second cache storing a copy of the block, where the second cache is associated with a second server in the clustered environment. The methods may further include transmitting a request to update the second cache with the received write data, and upon receiving a subsequent request to write subsequent data, identifying a third cache for invalidating based on access patterns of the blocks, where the third cache is associated with a third server in the clustered environment.

Abstract: Provided is a method for screening microRNAs with gene silencing function at both transcriptional and post-transcriptional levels. The microRNA obtained via the screening method can down-regulate the expression of mRNA of a target gene by binding to a specific site of 5?-flanking region of the target gene, and also down-regulate the expression of the protein of the target gene by binding to a specific site of the 3?-untranslated region of the target gene. Also provided are microRNAs obtained via the screening method, the use of the same in gene silencing, and a method of gene silencing by using the same.

Abstract: An indicia reading terminal can comprise an image sensor integrated circuit having a two-dimensional image sensor, a hand held housing encapsulating the two-dimensional image sensor, and an imaging lens configured to focus an image of a target decodable indicia onto the two-dimensional image sensor. The two-dimensional image sensor can include a plurality of pixels arranged in repetitive patterns. Each pattern can include at least one pixel sensitive in a first spectrum region, at least one pixel sensitive in a second spectrum region, and at least one pixel sensitive in a third spectrum region. The image sensor integrated circuit can be configured to capture a frame of image data by reading out a plurality of analog signals. Each read out analog signal can be representative of light incident on a group of two or more pixels of the plurality of pixels.

Abstract: A data recovery system is disclosed that permits recovery of data in a computer memory. The system includes an update storage system, a long-term storage system, a coupling functional circuit, and a parity register. The update storage system is for providing backup storage of recently updated data. The long-term storage system is for providing backup storage of data that has not been recently updated. The coupling functional circuit is for providing a bit-wise commutative binary operation of data from the update storage system and from the long term storage system. The parity register is for maintaining parity snapshots of the output of the coupling functional circuit.

Abstract: A system and method are disclosed for providing continuous file protection in a computer processing system. In accordance with an embodiment, the system includes a configuration module, a filter driver, and a storage module. The configuration module permits a user to elect certain files or folders for protection. The configuration module runs at an application layer without involving the computer processing system's operating system. The filter driver intercepts and splits write input and outputs addressed at protected files or folders. The storage module is also run without involving the computer processing system's operating system. The storage module is for performing functions including data logging, version managements, and data recovery.

Abstract: A method for forming a contact window includes: a step of providing a substrate; a step of forming a patterned amorphous carbon layer or spin-on coating layer, in which a surface of the substrate is exposed at two sides of the amorphous carbon layer or spin-on coating layer; a step of forming an interlayer dielectric layer on the substrate; a step of removing a portion of the interlayer dielectric layer until the patterned amorphous carbon layer or spin-on coating layer is exposed; a step of removing the patterned amorphous carbon layer or spin-on coating layer to form an opening; and a step of filling the opening with a conductive material to form the contact window.

Abstract: A method for forming a contact window includes: a step of providing a substrate; a step of forming a patterned amorphous carbon layer or spin-on coating layer, in which a surface of the substrate is exposed at two sides of the amorphous carbon layer or spin-on coating layer; a step of forming an interlayer dielectric layer on the substrate; a step of removing a portion of the interlayer dielectric layer until the patterned amorphous carbon layer or spin-on coating layer is exposed; a step of removing the patterned amorphous carbon layer or spin-on coating layer to form an opening; and a step of filling the opening with a conductive material to form the contact window.

Abstract: A data storage caching architecture supports using native local memory such as host-based RAM, and if available, Solid State Disk (SSD) memory for storing pre-cache delta-compression based delta, reference, and independent data by exploiting content locality, temporal locality, and spatial locality of data accesses to primary (e.g. disk-based) storage. The architecture makes excellent use of the physical properties of the different types of memory available (fast r/w RAM, low cost fast read SSD, etc) by applying algorithms to determine what types of data to store in each type of memory. Algorithms include similarity detection, delta compression, least popularly used cache management, conservative insertion and promotion cache replacement, and the like.

Abstract: A data storage caching architecture supports using native local memory such as host-based RAM, and if available, Solid State Disk (SSD) memory for storing pre-cache delta-compression based delta, reference, and independent data by exploiting content locality, temporal locality, and spatial locality of data accesses to primary (e.g. disk-based) storage. The architecture makes excellent use of the physical properties of the different types of memory available (fast r/w RAM, low cost fast read SSD, etc) by applying algorithms to determine what types of data to store in each type of memory. Algorithms include similarity detection, delta compression, least popularly used cache management, conservative insertion and promotion cache replacement, and the like.

Abstract: A data storage caching architecture supports using native local memory such as host-based RAM, and if available, Solid State Disk (SSD) memory for storing pre-cache delta-compression based delta, reference, and independent data by exploiting content locality, temporal locality, and spatial locality of data accesses to primary (e.g. disk-based) storage. The architecture makes excellent use of the physical properties of the different types of memory available (fast r/w RAM, low cost fast read SSD, etc) by applying algorithms to determine what types of data to store in each type of memory. Algorithms include similarity detection, delta compression, least popularly used cache management, conservative insertion and promotion cache replacement, and the like.