Abstract: A material conveying device includes a base frame, a first conveying unit, a second conveying unit and a transfer assembly. The first conveying unit is provided on the base frame, the second conveying unit is provided on the base frame, and the transfer assembly is provided on the base frame and can transfer a material between the first conveying unit and the second conveying unit. The present disclosure further provides a processing equipment facilitating material distribution and a material distribution method.

Abstract: The invention belongs to the field of biomedical research involving the 1,3,4-selenyldiazo derivatives that have cell protective activity. Because there are not so many heterocyclic selenium compounds, we synthesized a new type of selenium analog of BPTES. As the isoacceptor of BPTES, the compounds have antitumor activity, anti-oxidation and cell protection function. Currently many drugs contain the thiodiazo motif, so synthesis of selenyldiazo functional group could further optimize these drugs and are important in new drug development and application.

Abstract: A class of compounds of monosulfonic phenyltetrazole, with the structure of 2-(R1 phenyl)-5 (2-sulfonic phenyl)-2H-tetrazole. The 2-sulfonic phenyl tetrazolium salt of this invention has advantages of low toxicity, short synthetic route, easy control of purity and quality. As the 2-sulfonic phenyl tetrazolium salts has almost no absorption at 450 nm where the reduzate has greater absorption, spectrophotometry can simply and rapidly determine the activity of glutamate dehydrogenase, or the content of NADH/NADPH.

Abstract: The present invention relates to the field of biomedicine, and discloses a class of selenium-containing inhibitors that bind to the allosteric site of glutaminase, and/or inhibit glutamate dehydrogenase, which has a long carbon chain or similar derivative structure linked with the N atom of benzoisoselenazole 3-ketone. The advantages of this invention are that compounds have novel binding activity with glutaminase and potent inhibitory activity of glutaminase. Moreover, some novel dual KGA/GDH inhibitors demonstrated good in vivo efficacy in inhibiting the tumor growth in mice by blocking glutaminolysis. At the meantime, compounds of this invention play an important part in the protection of survival, growth and differentiation of nerve cells under the condition of hypoxia-ischemia.

Abstract: The invention belongs to the field of biomedical research involving the 1,3,4-selenyldiazo derivatives that have cell protective activity. Because there are not so many heterocyclic selenium compounds, we synthesized a new type of selenium analog of BPTES. As the isoacceptor of BPTES, the compounds have antitumor activity, anti-oxidation and cell protection function. Currently many drugs contain the thiodiazo motif, so synthesis of selenyldiazo functional group could further optimize these drugs and are important in new drug development and application.

Abstract: The present invention relates to the field of biomedicine, and discloses a class of selenium-containing inhibitors that bind to the allosteric site of glutaminase, and/or inhibit glutamate dehydrogenase, which has a long carbon chain or similar derivative structure linked with the N atom of benzoisoselenazole 3-ketone. The advantages of this invention are that compounds have novel binding activity with glutaminase and potent inhibitory activity of glutaminase. Moreover, some novel dual KGA/GDH inhibitors demonstrated good in vivo efficacy in inhibiting the tumor growth in mice by blocking glutaminolysis. At the meantime, compounds of this invention play an important part in the protection of survival, growth and differentiation of nerve cells under the condition of hypoxia-ischemia.

Abstract: A class of compounds of monosulfonic phenyltetrazole, with the structure of 2-(R1 phenyl)-5 (2-sulfonic phenyl)-2H-tetrazole. The 2-sulfonic phenyl tetrazolium salt of this invention has advantages of low toxicity, short synthetic route, easy control of purity and quality. As the 2-sulfonic phenyl tetrazolium salts has almost no absorption at 450 nm where the reduzate has greater absorption, spectrophotometry can simply and rapidly determine the activity of glutamate dehydrogenase, or the content of NADH/NADPH.

Abstract: A circuit includes an input channel array that includes a plurality of channels to receive a plurality of input signals and generate a plurality of channel output signals. A processor to processes the plurality of channel output signals from the input channel array. The processor and the input channel array are configured to operate in a sleep mode when all of the analog input signals are inactive or an active mode when at least one of the analog input signals is active. A secondary channel samples the plurality of input signals and generates a secondary output signal indicative of activity for at least one of the input signals. A secondary channel detector determines a level of signal activity for any of the input signals during the sleep mode based on the secondary output signal.

Abstract: A circuit includes an input channel array that includes a plurality of channels to receive a plurality of input signals and generate a plurality of channel output signals. A processor to processes the plurality of channel output signals from the input channel array. The processor and the input channel array are configured to operate in a sleep mode when all of the analog input signals are inactive or an active mode when at least one of the analog input signals is active. A secondary channel samples the plurality of input signals and generates a secondary output signal indicative of activity for at least one of the input signals. A secondary channel detector determines a level of signal activity for any of the input signals during the sleep mode based on the secondary output signal.