Abstract: Disclosed is a safe guidance method and Global Navigation Satellite System device thereof. The safe guidance method comprises steps: obtaining at least one caution zone from a map database of the Global Navigation Satellite System device; and playing a notification when approaching the caution zone according to a notifying rule. The safe guidance method further comprises a step of defining the caution zone before the step of obtaining the caution zone and a step of playing a warning after entering the caution zone. Furthermore, the notifying rule defines a distance near the caution zone for playing the notification. A user of the Global Navigation Satellite System device can define the caution zone and predetermine the aforesaid distance before the user travels on the road. The notification and the warning can be voice hints or image hints.