Abstract: The present invention relates to a pharmaceutical composition for preventing or treating diabetic stroke, containing at least one of a RAGE (receptor for advanced glycation end-products) antagonist or an AGE (advanced glycation end-products) scavenger. Administration of the composition to a subject can prevent or treat stroke with hyperglycemia. More specifically, administration of the composition to a subject inhibits brain injury caused by stroke with hyperglycemia.

Abstract: The present invention relates to (a) an active camptothecin derivative represented by Chemical Formula 1 below, which is designed to bind to the DDX5 protein and an E3 ligase; (b) a prodrug thereof designed to release the active camptothecin derivative (a) at an in vivo target site; or (c) a ligand-containing complex targeting the DDX5 protein, in which an topoisomerase-1 inhibitory ability of the active camptothecin derivative (a) or FL118 compound of Chemical Formula 2 is inactivated through linker conjugation. The active camptothecin derivative designed according to the present invention may bind to the DDX5 protein in cells to induce cell death through DDX5 protein degradation.

Abstract: An automatic electrode supply apparatus configured to automatically supply an electrode in various processes for manufacturing a secondary battery includes a first chuck splicing unit including a splicing portion having a traveling electrode located thereon and a second chuck splicing unit including a splicing portion having a standby electrode located thereon, wherein each of the first and second chuck splicing units includes an edge position control (EPC) sensor configured to measure the position of the edge of a corresponding one of the traveling electrode and the standby electrode in order to prevent distortion or fracture defect of the electrode due to positional deviation between the traveling electrode and the standby electrode, and an automatic electrode supply method using the same.

Abstract: A battery cell extraction device includes an adsorption part provided to be movable toward a battery cell stored in a tray, and provided to adsorb a first surface of the battery cell, and a guide part provided to be movable so that in a state where the first surface of the battery cell is adsorbed by the adsorption part, a second surface in a direction opposite to the first surface of the battery cell is supported, and including a plurality of elastic members disposed to contact the second surface of the battery cell.

Abstract: An electrolyte injection device for a battery cell according to one example includes a transfer member provided to be transferable along a first direction, a base member, which is disposed on the transfer member, for mounting at least one battery cell, an injection part for injecting an electrolyte into the battery cell located on the base member, and a clamping unit provided on the base member and provided to clamp both sides of the battery cell along the first direction.

Abstract: A position roller for meander control includes, in one example, a roller with a rotational axis; a first ball joint supporting a distal end among both ends of the rotational axis for pivotal movement; an XZ driver that drives a proximal end among both ends of the rotational axis into two-dimensional motion in a plane; and a base supporting the first ball joint and the XZ driver.

Abstract: The present disclosure relates to a cell packaging device. The cell packaging device can include a cell grip unit with a cell grip part including a first member provided with a roller and a second member disposed opposite to the first member at a predetermined interval to provide an insertion space to receive a cell. A gap adjusting part of the cell grip unit can adjust a gap between the first member and the second member. A transport part of the cell packaging unit can transport the cell grip unit.

Abstract: According to one example of the present disclosure, an electrode assembly manufacturing device may be provided, which comprises: a supply part supplying a packaging separator having a packaging length corresponding to the length of the electrode assembly; a packaging part provided so that the packaging separator supplied from the supply part is divided into a folded region and a reference region where the reference surface of the electrode assembly is seated, adsorbed, and seated, and provided to fold the packaging separator so that the folded region is placed on the opposite side of the electrode assembly facing the reference surface of the electrode assembly; and a sealing part sealing the packaging separator located on the opposite side to the electrode assembly after the packaging separator is folded.

Abstract: The present invention relates to pharmaceutical compositions for treating blood cancer, which includes 4?-thio-5-aza-2?-deoxycytidine (Aza-T-dCyd), and methods of treating blood cancer using a composition for oral administration that includes Aza-T-dCyd. The present invention provides a significant blood cancer therapeutic effect without having toxicity in a blood cancer mouse model or a human even with the Aza-T-dCyd dose conventionally known to have toxicity. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: A tape removal apparatus is configured for automatically removing a tape attached to an electrode roll in order to fix the electrode roll. The tape removal apparatus includes a sensing unit configured to sense the tape attached to the electrode roll, an injection unit configured to inject air toward the tape, a support unit configured to support a non-adhesive portion of the tape, and a gripper configured to fix the non-adhesive portion of the tape together with the support unit.

Abstract: The present disclosure relates to an electrode cutting device, including: a transfer unit that transfers an electrode; a vision unit that measures a misaligned angle of the electrode; a cutting unit including a cutter that cuts the electrode; and a control unit that controls the cutter, wherein the control unit adjusts a cutting angle of the cutter based on the misaligned angle of the electrode measured by the vision unit, and the cutting angle of the cutter is an angle formed by a blade of the cutter and an imaginary line perpendicular to a transfer direction of the electrode on a plane, and a cell manufacturing device including the same.

Abstract: An electrode roll connection automation apparatus is configured for uniformly maintaining the width of electrode tabs in a process of connecting electrode sheets to each other and for automatically connecting the electrode sheets to each other. The electrode roll connection automation apparatus includes first and second supply units, a connection unit, and an electrode tab sensing unit. The first and the second supply units are configured to supply first and second electrode sheets, respectively, on which electrode tabs are formed. The connection unit is configured to connect the first electrode sheet and the second electrode sheet to each other. The electrode tab sensing unit is disposed between the first supply unit and the connection unit. The electrode tab sensing unit is configured to measure the distance between the electrode tabs.

Abstract: A tape attachment apparatus includes a tape supply unit configured to provide a tape to be attached to a tip of an electrode roll, a tape attachment unit configured to attach the tape provided by the tape supply unit to the electrode roll, and a frame configured to allow the tape attachment unit to be mounted to the frame. A tape attachment process to prevent unwinding of the electrode roll is automatically performed.

Abstract: Disclosed herein is a battery cell packaging device. The battery cell packaging device can include a supply part supplying an insulating tape, an image acquisition part for photographing at least one of the insulating tape or a welded portion, an adsorption part including an adsorption member for adsorbing the supplied insulating tape and packaging the welded portion with the adsorbed insulating tape, and a cutting part for cutting the insulating tape adsorbed on the adsorption member from the supply part. The adsorption member can include a first adsorption block, and a second adsorption block foldably connected to the first adsorption block.

Abstract: An electrode sheet rewinding apparatus for rewinding an electrode sheet includes a bobbin having a PET film wound therearound, a bobbin holder configured to hold the bobbin, a base plate located under the bobbin holder and configured to support the bobbin holder, a roller type touch roll configured to press an electrode sheet rewound around the bobbin above the bobbin to prevent meandering of the electrode sheet, a vertical plate located at one side of the base plate, the touch roll attached to the vertical plate, and an idle roller unit configured to form a tangential line to the electrode sheet rewound around the bobbin together with the touch roll. The idle roller unit includes an idle roller configured to maintain tension of the electrode sheet and to form a tangential line to the electrode sheet and two driving mechanisms configured to change the position of the idle roller.

Abstract: The present invention relates to pharmaceutical compositions for treating blood cancer, which includes 4?-thio-5-aza-2?-deoxycytidine (Aza-T-dCyd), and methods of treating blood cancer using a composition for oral administration that includes Aza-T-dCyd. The present invention provides a significant blood cancer therapeutic effect without having toxicity in a blood cancer mouse model or a human even with the Aza-T-dCyd dose conventionally known to have toxicity. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: A pouch roll replacement system comprises a transport part, a replacement chucking part, an unwinder chucking part, a measuring part, and a control part. The transport part transports a replacement pouch roll and is capable of adjusting the central axis height of the replacement pouch roll The replacement chucking part is provided to chuck the replacement pouch roll transported through the transport part and has a predetermined chucking height The unwinder chucking part accommodates a traveling pouch roll and the measuring part measures the distance to the replacement pouch roll seated on the transport part before transporting the replacement pouch roll to the replacement chucking part. The control part controls the transport part so that the central axis height of the replacement pouch roll seated on the transport part is adjusted based on the measurement information of the measuring part and the chucking height of the replacement chucking part.

Abstract: A method of manufacturing a secondary battery includes accommodating an electrode assembly in a battery part communicating with a gas collection part of the battery case; positioning a gas discharge pipe in an open portion of the battery case at the side edge, wherein the gas discharge pipe is configured to discharge a gas and inject an electrolyte; and simultaneously fixing the gas discharge pipe to the battery case and sealing the battery case by sealing the open portion and the gas discharge pipe together. The method may efficiently remove an activation process gas using a gas discharge pipe capable of performing both gas discharge and electrolyte injection and is simplified by simultaneously sealing the gas discharge pipe and sealing a battery case.

Abstract: A tape removal apparatus is configured for automatically removing a tape attached to an electrode roll in order to fix the electrode roll. The tape removal apparatus includes a sensing unit configured to sense the tape attached to the electrode roll, an injection unit configured to inject air toward the tape, a support unit configured to support a non-adhesive portion of the tape, and a gripper configured to fix the non-adhesive portion of the tape together with the support unit.

Abstract: Disclosed is a hybrid driving module. A hybrid driving module according to an embodiment of the present invention is configured to selectively transmit rotational power, which is transmitted from an engine and a motor, to a transmission and includes an internal chamber including an inlet port and an outlet port for a working fluid, a torsion damper including a torque input part rotationally fixed to the engine, and a torque output part, and a one-way clutch connected to the torque output part, in which the torsion damper and the one-way clutch are disposed in the internal chamber.