Abstract: The present invention relates to water soluble magnetic nanocomposite using an amphiphilic compound. Specifically, the present invention relates to water soluble magnetic nanocomposite which may be not only used as a contrast agent for magnetic resonance imaging (MRI), an intelligent contrast agent for diagnosing cancer characterized by binding a tissue-specific binder ingredient, a drug delivery system for simultaneous diagnosis and treatment by polymerizing or enveloping drugs and binding a tissue-specific binder ingredient, but also used for separating a target substance using magnetism, and a process for preparing the same.

Abstract: The present invention relates to a manganese-containing metal oxide nanoparticle-based magnetic resonance imaging (MRI) contrast agent, which is characterized in that: The core of it comprises 1 to 1000 nm-sized manganese-containing metal oxide nanoparticles which include MnO a (0<a<5) or MnMbOe (wherein M is at least one metal atom selected from the group consisting of a Group 1 or 2 element such as Li, Na, Be, Ca, Ge, Mg, Ba, Sr and Ra, a Group 13 element such as Ga and In, a transition metal element such as Y, Ta, V, Cr, Co, Fe, Ni, Cu, Zn, Ag, Cd and Hg, and lanthanide or actinide group elements such as La, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm and Yb, 0<b<5 and 0<c<10); preferably MnM?dFeeOf (wherein M? is at least one metal atom selected from the group consisting of a Group 1 or 2 element such as Li, Na, Be, Ca, Ge, Mg, Ba, Sr and Ra, a Group 13 element such as Ga and In, a transition metal element such as Y, Ta, V, Cr, Co, Fe, Ni, Cu, Zn, Ag, Cd and Hg, and lanthanide or acti

Abstract: Disclosed are a targeting magnetic nanosphere preparation capable of diagnosing and treating tumors in mammals and a method of manufacturing the same. The smart magnetic nanosphere preparation contains magnetic nano-sized iron oxide nanoparticles, which can be detected by magnetic resonance imaging (MRI), as a core material. The core material is encapsulated in a size of tens to hundreds of nanometers allowing particles to penetrate into deep areas of biological tissues using a biodegradable polymer having high affinity for biological tissues. The formed capsules are surface-modified with an antibody specific to a specific tumor. The smart magnetic nanosphere preparation can effectively diagnose tumors, as well as treat tumors because it has an antibody to a specific tumor.