Abstract: Disclosed is an IgG Fc fragment useful as a drug carrier. A recombinant vector expressing the IgG Fc fragment, a transformant transformed with the recombinant vector, and a method of preparing an IgG Fc fragment are disclosed. When conjugated to a certain drug, the IgG Fc fragment improves the in vivo duration of action of the drug and minimizes the in vivo activity reduction of the drug.

Abstract: Disclosed is an IgG Fc fragment useful as a drug carrier. A recombinant vector expressing the IgG Fc fragment, a transformant transformed with the recombinant vector, and a method of preparing an IgG Fc fragment are disclosed. When conjugated to a certain drug, the IgG Fc fragment improves the in vivo duration of action of the drug and minimizes the in vivo activity reduction of the drug.

Abstract: Disclosed is an IgG Fc fragment useful as a drug carrier. Also, the present invention discloses a recombinant vector expressing the IgG Fc fragment, a transformant transformed with the recombinant vector, and a method of preparing an IgG Fc fragment, comprising culturing the transformant. When conjugated to a certain drug, the IgG Fc fragment improves the in vivo duration of action of the drug and minimizes the in vivo activity reduction of the drug.

Abstract: Disclosed are a recombinant expression vector comprising a nucleotide sequence encoding an E. coli-derived signal sequence and a nucleotide sequence encoding an immunoglobulin constant region, and a transformant transformed with the expression vector. Also, disclosed is a method of mass-producing an immunoglobulin constant region by culturing the transformant and expressing the immunoglobulin constant region in a water-soluble form.

Abstract: A photosensitive resin composition includes: an acrylic copolymer comprising a polymerization product of a first monomer comprising at least one selected from an unsaturated carboxylic acid and an unsaturated carboxylic acid anhydride, and a second monomer comprising an olefin-based unsaturated compound; a photosensitive component comprising at least one 1,2-quinonediazide-5-sulfonic acid ester compound selected from compounds represented by Chemical Formulae 1 to 4; a coupling agent; and a solvent, wherein a total amount of asymmetric compounds in the photosensitive component is greater than or equal to 45 area percent as determined by high performance liquid chromatography: wherein R1 is a hydroxyl group or a methyl group, and NQD is a 1,2-quinonediazide 5-sulfonyl group.

Abstract: A guide thimble plug for a nuclear fuel assembly is provided, in which an internal threaded hole is formed through a main body so that the main body is coupled to a bottom nozzle by a screw coupling. An upper insert part is formed in the upper end of the main body. The upper insert part is inserted into a shock absorption tube. A thermal deformation prevention part is formed on the main body below the upper insert part and is recessed inward from the outer surface of the main body such that, when the main body is coupled to the guide thimble, a gap is defined between the thermal deformation prevention part and the guide thimble. The guide thimble and the shock absorption tube can be reliably fastened to the bottom nozzle, and thermal deformation of the guide thimble can be minimized.

Abstract: Disclosed herein is a spacer grid for a nuclear fuel assembly. The spacer grid has dimples for supporting fuel rods and is formed from grid strips which are assembled in a lattice shape to form lattice cells. Each grid strip has at least one hole which is formed separately from the dimples. Therefore, when coolant is drawn into the fuel assembly, a pressure difference between opposite sides of the holes is reduced, and friction generated between cut edges of the holes and the coolant reduces the magnitude of the vibration and causes a damping effect, thus reducing flow-induced vibration. The hole formed in the grid strip function to widen the range of the frequency of the flow-induced vibration caused by vortex sheddings formed around the edges of the grid strip, thus reducing the possibility of the generation of resonance with the natural frequency of the spacer grid.

Abstract: Disclosed herein is a spacer grid for a nuclear fuel assembly which is formed from grid strips of an improved structure, thus reducing flow-induced high-frequency vibration. The spacer grid has dimples or grid springs for supporting fuel rods and is formed from a plurality of grid strips assembled in a lattice shape to form lattice cells. Each of the grid strips has at least one slot formed in a planar portion of the grid strip separately from the dimple or grid spring. Therefore, characteristics of the vibration of the spacer grid can be set in a variety of different manners so that flow-induced high-frequency vibration can be reduced.

Abstract: A hold-down spring unit for a top nozzle of a nuclear fuel assembly. The hold-down spring unit is coupled to the upper end of the top nozzle of the nuclear fuel assembly. The hold-down spring unit includes a first spring which provides a hold-down force upon the nuclear fuel assembly under start-up conditions or hot full power conditions of a nuclear reactor, and a second spring which provides an additional hold-down force upon the nuclear fuel assembly under start-up conditions of the nuclear reactor. The hold-down margin under start-up conditions or hot full power conditions is reduced, thus enhancing the mechanical and structural stability of the nuclear fuel assembly.

Abstract: A hold-down spring unit for a top nozzle of a nuclear fuel assembly. The hold-down spring unit is coupled to the upper end of the top nozzle of the nuclear fuel assembly. The hold-down spring unit includes a first spring which provides a hold-down force upon the nuclear fuel assembly under start-up conditions and hot full power conditions of a nuclear reactor, and a second spring which provides an additional hold-down force upon the nuclear fuel assembly under start-up conditions of the nuclear reactor. The hold-down margin under start-up conditions and hot full power conditions is reduced, thus enhancing the mechanical and structural stability of the nuclear fuel assembly.

Abstract: The present invention relates to a long-acting interferon beta formulation having improved in vivo duration and stability, comprising an interferon beta conjugate that is prepared by covalently linking interferon beta with an immunoglobulin Fc region via a non-peptidyl polymer, and a preparation method thereof. The long-acting interferon beta formulation of the present invention maintains in vivo activity of interferon beta at a relatively high level and remarkably increases the serum half-life thereof, thereby being used for various diseases, for which interferon is efficacious.

Abstract: A hold-down spring unit for a top nozzle of a nuclear fuel assembly. The hold-down spring unit is coupled to the upper end of the top nozzle of the nuclear fuel assembly. The hold-down spring unit includes a first spring which provides a hold-down force upon the nuclear fuel assembly under start-up conditions or hot full power conditions of a nuclear reactor, and a second spring which provides an additional hold-down force upon the nuclear fuel assembly under start-up conditions of the nuclear reactor. The hold-down margin under start-up conditions or hot full power conditions is reduced, thus enhancing the mechanical and structural stability of the nuclear fuel assembly.

Abstract: Disclosed is a spacer grid assembly with mixing vanes supporting fuel rods of nuclear fuel assemblies and mixing coolant that flows around the fuel rods, and more particularly, a spacer grid equipped with mixing vanes that mix coolant flowing around fuel rods. The spacer grid with hydraulically balanced mixing vane patterns, in the spacer grid equipped with a strip dividing a plurality of unit grid cells and a plurality of springs, protruded in uniform directions of vertical and horizontal directions on a grid surface of the strip and supporting nuclear fuel rods, which includes: a plurality of mixing vanes protruded to the downstream of coolant on an upper end of the inner grid surface, wherein positions and directions of the mixing vanes are formed in regular patterns on the spacer grid. Thus, it can minimize coolant flow induced vibration of the spacer grid by balancing hydraulic load generated by the mixing vanes, around the center of the spacer grids.

Abstract: A photosensitive composition and a method of manufacturing a substrate used for a display device are disclosed. The photosensitive composition includes an acrylic based copolymer, a photo-initiator, a photo-sensitizer and a solvent. Thus, a photosensitivity of the photosensitive composition for ultra violet light of a long wavelength may be improved.

Abstract: A top nozzle is provided. The top nozzle can include a coupling plate, a perimeter wall and a hold-down spring unit. The coupling plate can be coupled to a guide thimble of the nuclear fuel assembly. The perimeter wall can protrude upwards from the perimeter of the coupling plate. A spring clamp can be provided on the upper surface of the perimeter wall. The hold-down spring unit can be mounted to the upper surface of the perimeter wall in such a way to couple a corresponding end of the hold-down spring unit to the spring clamp. A fastening pin hole can be vertically formed through an upper surface of the spring clamp. A spring insert hole into which the hold-down spring unit can be inserted and formed by electro-discharge machining in an insert direction of the hold-down spring.

Abstract: The present invention relates to a top nozzle for a nuclear fuel assembly that has a two-stage elastic section such that a pushing force against the axial movement of the nuclear fuel assembly under normal conditions is optimized and at the same time a suppressing force against a drastic uplifting force of the nuclear fuel assembly under transient conditions is strengthened, and that lowers the elastic coefficients of the springs operating under normal conditions more than those of existing coil springs, thereby providing an optimal pushing force against the nuclear fuel assembly.

Abstract: The present invention relates to a photosensitive resin composition, particularly to a photosensitive resin composition for forming an interlayer organic insulating film for TFT-LCD, comprising 0.01 to 20 wt % of UV stabilizer or radical scavenger. The photosensitive resin composition of the present invention can be used for forming an interlayer organic insulating film for TFT-LCD to improve active unfilled area upon over exposure in liquid crystal photo-alignment process, can easily control resolution of pattern, and is particularly suitable for forming a planarization layer of an interlayer organic insulating film.

Abstract: A photoresist composition suitable for forming a high-resolution pattern, and a method of forming a photoresist pattern using the same. The photoresist composition includes about 10 to about 45 parts by weight of an alkali soluble binder resin including a hydroxyl group, about 0.1 to about 5 parts by weight of a photo-acid generator, about 1 to about 5 parts by weight of a cross-linker that cross-links the alkali-soluble binder resin including the hydroxyl group, about 0.3 to about 3 parts by weight of a quinone diazide compound, and a remainder of a solvent.

Abstract: Disclosed are a recombinant expression vector comprising a nucleotide sequence encoding an E. coli-derived signal sequence and a nucleotide sequence encoding an immunoglobulin constant region, and a transformant transformed with the expression vector. Also, disclosed is a method of mass-producing an immunoglobulin constant region by culturing the transformant and expressing the immunoglobulin constant region in a water-soluble form.

Abstract: Disclosed are a recombinant expression vector comprising a nucleotide sequence encoding an E. coli-derived signal sequence and a nucleotide sequence encoding an immunoglobulin constant region, and a transformant transformed with the expression vector. Also, disclosed is a method of mass-producing an immunoglobulin constant region by culturing the transformant and expressing the immunoglobulin constant region in a water-soluble form.