Abstract: An ophthalmic intraoperative imaging system may include a handheld light probe including a first optical fiber and a second optical fiber. The system may include an illumination light source configured to transmit an illumination beam for intraocular illumination via the first optical fiber of the light probe. The system may include an optical coherence tomography (OCT) light source configured to transmit an OCT beam towards an intraocular region of interest (ROI) via the second optical fiber of the light probe. The system may include an OCT detector configured to detect light reflected by the intraocular ROI. The system may include a processor configured to control the illumination light source and the OCT light source, obtain an OCT signal, obtain a B-mode OCT image of the intraocular ROI by freehand sweeping of the handheld light probe across the intraocular ROI, and control a display to display the B-mode OCT image.

Abstract: A common-path swept source optical coherence tomography (CP-SSOCT) distal sensor guided manual injection system for transscleral subretinal injection and methods of use thereof for delivering one or more therapeutic agents, including genes, to a subretinal space of an eye is provided.

Abstract: The present invention is directed to a device for the access and delivery of cells or other materials to the subretinal space. The device of the present invention accesses the subretinal space via the trans-scleral side. This is an ah externo approach. The device includes two stacked layers, surrounded by a flexible outer surface and an OCT-sensor integrated guide needle. The device is configured to be flexible, such that it conforms to the natural curvature of the eye as it is advanced to the subretinal space. After the device is in place, the flexible outer surface is configured to protect the delicate tissue of the retina and choroid, while there is also easy passage of the material or cells to be delivered between the two stacked layers.

Abstract: The present invention is directed to endoscopic structure illumination to provide simple, inexpensive 3D endoscopic technique to conduct high resolution 3D imagery for use in surgical guidance system. The present invention is directed to an FPP endoscopic imaging setup which provides a wide field of view (FOV) that addresses a quantitative depth information and can be integrated with commercially available endoscopes to provide tissue profilometry. Furthermore, by adapting a flexible camera calibration method for the 3D reconstruction technique in free space, the present invention provides an optimal fringe pattern for the inner tissue profile capturing within the endoscopic view and validate the method using both static and dynamic samples that exhibits a depth of field (DOF) of approximately 20 mm and a relative accuracy of 0.1% using a customized printed calibration board. The presented designs enable flexibility in controlling the deviated angle necessary for single scope integration using FPP method.

Abstract: An observation system for viewing light-sensitive tissue includes an illumination system configured to illuminate the light-sensitive tissue, an imaging system configured to image at least a portion of the light-sensitive tissue upon being illuminated by the illumination system, and an image display system in communication with the imaging system to display an image of the portion of the light-sensitive tissue. The illumination system is configured to illuminate the light-sensitive tissue with a reduced amount of light within a preselected wavelength range compared to multispectral illumination light, and the image of the portion of the light-sensitive tissue is compensated for the reduced amount of light within the preselected frequency range to approximate an image of the light-sensitive tissue under the multispectral illumination.

Abstract: An optical coherence tomography system having real-time artifact and saturation correction includes an optical coherence tomography unit, and a signal processing and display system adapted to communicate with the optical coherence tomography unit to receive imaging signals therefrom. The optical coherence tomography system is a Fourier Domain optical coherence tomography system. The signal processing and display system includes a parallel processor configured to correct the imaging signals, in real time, to at least partially remove image artifacts and saturation based on a subset of image data within an image frame.

Abstract: An optical coherence tomography (OCT) system for real-time surgical guidance includes an optical source, an optical fiber configured to be optically coupled to the optical source, a plurality of OCT sensor heads configured to be optically coupled to the optical fiber, an optical detector configured to be optically coupled to the optical fiber, a signal processor configured to communicate with the optical detector to receive detected signals therefrom, and a display system configured to receive OCT image signals from the signal processor and to display an OCT image of at least a portion of a surgical region of interest in real time to provide surgical guidance.

Abstract: A real-time, three-dimensional optical coherence tomography system includes an optical interferometer configured to illuminate a target with light and to receive light returned from the target; an optical detection system arranged in an optical path of light from the optical interferometer after being returned from the target, the optical detection system providing output data signals; and a data processing system adapted to communicate with the optical detection system to receive the output data signals. The data processing system includes a parallel processor configured to process the output data signals to provide real-time, three-dimensional optical coherence tomography images of the target.

Abstract: A motion-compensating surgical tool system includes a surgical tool that includes a hand piece and a moveable component, a drive assembly connecting the moveable component to the hand piece such that the moveable component is movable in an axial direction relative to the hand piece by the drive assembly. The motion-compensating surgical tool system also includes an optical detection system that includes an optical fiber attached to the moveable component with an end at a fixed distance to a distal-most portion of the moveable component. The optical detection system is configured to output a signal for the determination of a distance of the distal-most portion of the moveable component to a target during surgery.

Abstract: An observation system for viewing light-sensitive tissue includes an illumination system configured to illuminate the light-sensitive tissue, an imaging system configured to image at least a portion of the light-sensitive tissue upon being illuminated by the illumination system, and an image display system in communication with the imaging system to display an image of the portion of the light-sensitive tissue.