Abstract: The present invention is directed to orally administered compositions of topically acting corticosteroids for the treatment of inflammation of the gastrointestinal tracts such as eosinophilic esophagitis. The present invention also provides a method for treating conditions associated with inflammation of the gastrointestinal tract in an individual. The method comprises administering to an individual in need thereof a pharmaceutical composition of the present invention as orally disintegrating tablets comprising a topically active corticosteroid adsorbed onto a pharmaceutically acceptable carrier such as silicified microcrystalline cellulose.

Abstract: The present invention provides polyethylene-based compositions suitable for packaging applications, films, and articles. In one aspect, a polyethylene-based composition suitable for packaging applications comprises (a) at least 97% by weight, based on the total weight of the polyethylene-based composition, of a polyethylene composition comprising: (i) from 25 to 37 percent by weight of a first polyethylene fraction having a density in the range of 0.935 to 0.947 g/cm3 and a melt index (I2) of less than 0.1 g/10 minutes; and (ii) from 63 to 75 percent by weight of a second polyethylene fraction; and (b) 90 to 540 ppm, based on the total weight of the polyethylene-based composition of a calcium salt of 1,2-cyclohexanedicarboxylic acid; wherein the polyethylene composition has less than 0.10 branches per 1,000 carbon atoms when measured using 13C NMR, wherein the density of the polyethylene-based composition N is at least 0.965 g/cm3, and wherein the melt index (I2) of the polyethylene-based composition is 0.

Abstract: A receiver architecture is described for phase noise compensation in the presence of inter-channel interference (ICI) and inter-symbol interference (ISI), particularly for time-frequency packing (TFP) transmissions. The receiver includes a coarse phase noise (PN) estimator, a PN compensation module, an ICI cancellation module, an ISI compensation module, a FEC decoder, and an iterative PN estimator. The iterative PN estimator receives log likelihood ratio (LLR) information from the decoder and provides an iterative PN estimation to the PN compensation module. The decoder also provides LLR to the ISI compensation module, and to at least one other receiver for another subchannel that is immediately adjacent in frequency. The ICI cancellation module receives decoder output from at least one adjacent subchannel, which the ICI cancellation module uses to provide a ICI-cancelled signal.

Abstract: Small molecule regulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing SRC-related diseases. The SRC-related diseases can include cancer, metabolic disorders, human immunodeficiency virus, neurodegenerative disorders, and/or inflammatory diseases. Also provided are methods for regulating SRC family proteins in a cell.

Abstract: A T-breaker is an all-in-one solution for dc microgrid fault protection, power flow control, and power quality improvement. A T-breaker features a modular multilevel “T” structure with integrated energy storage devices. The two horizontal arms of the T-breaker realize fault current breaking, load voltage compensation, and power flow control; and the vertical arm of the T-breaker realizes shunt compensation. The configuration provides excellent voltage scalability and relaxes the requirements on the switching signal synchronization during fault transients. The local energy storage in sub-modules eases the fault energy dissipation requirement placed on the traditionally-adopted surge arrestors. The modular multilevel structure also offers immense control flexibility for all types of targeted functions of the provided T-breaker.

Abstract: Aspects of the subject disclosure may include, for example, a method comprising obtaining media content; receiving a request from equipment of a user to view the media content; identifying a predicted field of view of the user; sending a base layer of the media content to the equipment of the user using a first stream; and sending a first enhancement layer of the predicted field of view to the equipment of the user using a second stream. The first stream and the second stream may utilize different protocols, different servers, different buffer sizes, and/or a combination thereof. While the first stream may include an entire 360 degrees of the base layer of the media content, the second stream may be limited to the first enhancement layer of the predicted field of view of the media content. Other embodiments are disclosed.

Abstract: A method and apparatus are provided for updating a sequence hopping (SH) pattern of an uplink channel during handover from a current cell having a current SH pattern. At least one downlink channel of each neighbor cell of the current cell is monitored. Information indicative of the monitored downlink channels of the neighbor cells is transmitted to the current cell. Prior to receiving a handover command from the current cell a target cell from among the neighbor cells is anticipated and a common downlink channel of the anticipated target cell is monitored to determine information representative of a target SH pattern of the target cell.

Abstract: A display panel includes a plurality of sub-pixels. At least one sub-pixel of the plurality of sub-pixels includes a first electrode, a light modulation structure disposed on a side of the first electrode, and a second electrode disposed at a side of the light modulation structure away from the first electrode. The light modulation structure includes a refractive index adjustment layer, and a light modulation layer disposed between the refractive index adjustment layer and the first electrode. A refractive index of the refractive index adjustment layer is changed under action of an electric field between the first electrode and the second electrode. The light modulation layer is in contact with the refractive index adjustment layer, and at least a part of a surface of the light modulation layer that is in contact with the refractive index adjustment layer is a curved face.

Abstract: A computing device includes a processor and a machine-readable storage medium storing instructions. The instructions are executable by the processor to: receive input data defining an information technology (IT) change request; in response to a receipt of the input data, perform a first risk classification of the IT change request using a decision tree model; generate a graphical user interface based on the first risk classification, the graphical user interface indicating risk impacts for each of a plurality of request features, and the graphical user interface including a graphic representation of the decision tree model; in response to a user modification to a first request feature of the plurality of request features in the graphical user interface, automatically perform a second request analysis using the decision tree model; and automatically update the graphical user interface based on the second request analysis.

Abstract: The present disclosure relates to a display substrate. The display substrate may include a base substrate, a light filtering layer on the base substrate, a plurality of light blocking grooves in the light filtering layer, and a plurality of light blocking strips in the plurality of light blocking grooves respectively. The plurality of light blocking strips may be configured to block light from viewing angles outside a visible range of the display substrate.

Abstract: The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.

Abstract: In some examples, an apparatus for automated removal of noise in a frequency domain receives an image captured by an image sensor, converts at least a portion of the image into a frequency domain image, identifies a position in the frequency domain image, the position indicating a boundary between target content in the frequency domain image and noise in the frequency domain image, and removes content in the frequency domain image outside the boundary, to produce a noise-attenuated image.

Abstract: Disclosed is a snap-on quick-release lock mechanism for an unmanned aerial vehicle, including: a lock plate; a lock base; and a handle. The lock base is provided with a rotatable connecting member, the lock base is connected to the handle through the connecting member, and the handle is connected to the lock plate by snapping.

Abstract: Aspects of the subject disclosure may include, for example, applying a model to a first unlabeled traffic item to generate a classification of the first unlabeled traffic item as a first class of traffic items or a second class of traffic items, generating a first score that is representative of a first confidence of the classification, determining that the first score is greater than a first threshold, and responsive to determining that the first score is greater than the first threshold, refining the model in accordance with at least the classification, resulting in a modified model. Other embodiments are disclosed.

Abstract: Aspects of the subject disclosure may include, for example, selecting a set of traffic counters, wherein the traffic counters provide a profile of viewing habits of a user, and wherein the traffic counters are extracted from video streaming by the user; predicting a size of a video buffer based on the traffic counters selected; and building the video buffer based on the predicted size. Other embodiments are disclosed.

Abstract: As part of carrier assignment and configuration for multicarrier wireless communications, a single uplink (UL) primary carrier may provide control information for multiple concurrent downlink (DL) carriers. Optionally, control information for each DL carrier may be transmitted over paired UL carriers. Carrier switching of UL and/or DL carriers, including primary and anchor carriers, may occur during normal operation or during handover, and may occur in only the UL or only the DL direction. A unidirectional handover is performed when only an UL carrier or only a DL carrier is switched as part of a handover. Switching of UL and/or DL carriers may be from one component carrier or a subset of carriers to another component carrier, another subset of carriers, or all carriers in the same direction.

Abstract: A method for controlling discontinuous reception in a wireless transmit/receive unit includes defining a plurality of DRX levels, wherein each DRX level includes a respective DRX cycle length and transitioning between DRX levels based on a set of criteria. The transitioning may be triggered by implicit rules.

Abstract: Aspects of the subject disclosure may include, for example, receiving a first plurality of operating parameters associated with a first plurality of communication devices, obtaining a first prediction of a performance of a first communication device included in the first plurality of communication devices that is based on an application of the first plurality of operating parameters to a model, and responsive to a determination that the first prediction of the performance is inadequate in accordance with a first threshold, transmitting a first command to at least one communication device included in the first plurality of communication devices to modify at least one operating parameter of the at least one communication device. Other embodiments are disclosed.

Abstract: A method and apparatus for accessing a random access channel (RACH) during handover are disclosed. A handover procedure is initiated and a maximum handover interruption timer is activated. A dedicated preamble is transmitted in an attempt to access the RACH on a condition that the dedicated preamble is reserved in a current random access opportunity and the maximum handover interruption timer has not expired. A contention-based preamble is transmitted in an attempt to access the RACH on a condition that a dedicated preamble is not reserved in a current random access opportunity. If the maximum handover interruption timer has expired, a contention-based preamble is transmitted in an attempt to access the RACH.