Abstract: Disclosed herein are integrated circuit design system and method including: a genetic algorithm model unit configured to form a first parent generation using a performance simulation result for an arbitrary integrated circuit design point, form a child generation from the first parent generation using a genetic algorithm, form a surrounding design point based on the first parent generation as a mutant generation, and then select N points with the highest performance among the first parent generation, the child generation, and the mutant generation as a second parent generation; a comparison unit configured to compare a design range of the second parent generation and a preset reference range; and a regression model unit configured to train a regression model using the design range of the second parent generation when a design range of the second parent generation is narrower than or equal to the preset reference range.

Abstract: There is provided a composition including a 3-bromo-4,5-dihydroxybenzaldehyde (BDB) for protecting human skin keratinocyte from ultraviolet, in which the BDB has a photo-protective effect against cell damage caused by ultraviolet in human HaCaT skin keratinocyte, activity of removing a free radical, and ultraviolet absorption activity, and inhibits formations of lipid peroxidation and protein carbonyl, inhibits DNA damage, protects a cell, and thereby exhibits cell protective activity. Thus, the BDB decreases apoptosis induced by ultraviolet, and then protect a cell to recover cell viability.

Abstract: There is provided a composition including a 3-bromo-4,5-dihydroxybenzaldehyde (BDB) for protecting human skin keratinocyte from ultraviolet, in which the BDB has a photo-protective effect against cell damage caused by ultraviolet in human HaCaT skin keratinocyte, activity of removing a free radical, and ultraviolet absorption activity, and inhibits formations of lipid peroxidation and protein carbonyl, inhibits DNA damage, protects a cell, and thereby exhibits cell protective activity. Thus, the BDB decreases apoptosis induced by ultraviolet, and then protect a cell to recover cell viability.

Abstract: The present invention relates to a composition for preventing and treating inflammatory diseases and immune diseases, containing a Sargassum muticum extract and apo-9?-fucoxanthinone as active ingredients. According to the present invention, the Sargassum muticum extract and apo-9?-fucoxanthinone show an excellent inhibiting activity for the generation of IL-12, IL-6 and TNF-?, which are inflammatory cytokines, in a macrophage and a dendritic cell due to a stimulating factor causing an inflammatory response, remarkably inhibit MAPK and AP-1 activity, and inhibit the activity of NLRP3 inflammasome which is known to be involved in the pathogenesis of various immune inflammatory diseases, and thus can be ultimately useful for the development of an agent for treating inflammatory diseases and immune diseases caused by an excessive immune inflammatory response.

Abstract: There is provided a composition including a 3-bromo-4,5-dihydroxybenzaldehyde (BDB) for protecting human skin keratinocyte from ultraviolet, in which the BDB has a photo-protective effect against cell damage caused by ultraviolet in human HaCaT skin keratinocyte, activity of removing a free radical, and ultraviolet absorption activity, and inhibits formations of lipid peroxidation and protein carbonyl, inhibits DNA damage, protects a cell, and thereby exhibits cell protective activity. Thus, the BDB decreases apoptosis induced by ultraviolet, and then protect a cell to recover cell viability.