Abstract: Systems and methods for automatically acquiring and rotating an ultrasound volume based on a localized target structure are provided. The method includes performing a first ultrasound image acquisition and automatically detecting and tracking one or more anatomical structures in the first ultrasound image acquisition. The method includes presenting a region of interest surrounding each of the one or more anatomical structures in the first ultrasound image acquisition. The method includes performing a second ultrasound image acquisition of the region of interest to acquire a volume. The method includes estimating a pose of the one or more anatomical structures within the volume and calculating a rotation of the volume from the estimated pose to a pre-defined orientation of the one or more anatomical structures. The method includes presenting a rendering of the volume automatically rotated to the pre-defined orientation.