Patents by Inventor JinChun YUAN

JinChun YUAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250034080
    Abstract: A novel type of cationic lipid and PEGylated derivative thereof, a cationic liposome and a cationic liposome-nucleic acid pharmaceutical composition containing the cationic lipid and formulation thereof include an ionizable lipid compound of the general formula (1). This compound is slightly ionized or neutral at physiological pH but undergoes greater ionization under acidic conditions, exhibiting lower toxicity in the systemic circulation and improved endosomal escape ability. The compound's polar head contains an ionizable tertiary amine group along with a side chain containing functional groups, while the tail chains may include linking groups that are easily degraded. Cationic liposomes containing the compound have a better ability to complex with nucleic acid drugs, higher stability in serum, no apparent cytotoxicity, and high transfection efficiency.
    Type: Application
    Filed: January 1, 2023
    Publication date: January 30, 2025
    Applicant: XIAMEN SINOPEG BIOTECH CO., LTD.
    Inventors: Sheng LIN, Minggui LIN, Dandan CHEN, Ailan WANG, Congming LIN, Qi ZHU, Wengui WENG, Chao LIU, Jinchun YUAN
  • Publication number: 20240335384
    Abstract: A novel cationic lipid having a structure as represented by general formula (1), which specifically relates to a nitrogen-containing cationic lipid, and also relates to a liposome containing the cationic lipid, a liposome pharmaceutical composition containing said cationic lipid, preparation and application thereof. A cationic liposome containing the cationic lipid represented by formula (1), can improve the loading rate and transport rate of drugs, particularly nucleic acid drugs. The terminus of the novel cationic lipid can contain a fluorescent group or a targeting group, so that the cationic liposome pharmaceutical composition containing the cationic lipid can have fluorescent or targeting function.
    Type: Application
    Filed: October 13, 2022
    Publication date: October 10, 2024
    Applicant: XIAMEN SINOPEG BIOTECH CO., LTD.
    Inventors: Sheng LIN, Minggui LIN, Ailan WANG, Linlin WANG, Wengui WENG, Chao LIU, Jinchun YUAN, Qian LIN
  • Publication number: 20220118100
    Abstract: The monofunctional branched poly(ethylene glycol) (PEG) has a general formula shown in formula (1), and the bio-related substance modified by the monofunctional branched PEG has a general formula shown in formula (2), wherein X1 and X2 are each independently a hydrocarbon group having 1 to 20 carbon atoms, n1 and n2 are each independently an integer selected from 1 to 1000, n3 is an integer selected from 11 to 1000, L1, L2 are each independently a linking group, p is 0 or 1, q is 0 or 1, R1 is a hydrogen atom or a hydrocarbon group having 1 to 20 carbon atoms, D is a bio-related substance, Z is a linking group, and Z can react with the bio-related substance to form a residue group L3. The PEG-modified bio-related substance maintains good biological activity, and has better solubility and a longer half-life in vivo.
    Type: Application
    Filed: December 23, 2021
    Publication date: April 21, 2022
    Applicant: Xiamen Sinopeg Biotech Co., Ltd.
    Inventors: WenGui WENG, Chao LIU, JinCheng LIAO, JinChun YUAN
  • Publication number: 20140199750
    Abstract: The monofunctional branched poly(ethylene glycol) (PEG) has a general formula shown in formula (1), and the bio-related substance modified by the monofunctional branched PEG has a general fomula shown in formula (2), wherein X1 and X2 are each independently a hydrocarbon group having 1 to 20 carbon atoms, n1 and n2 are each independently an integer selected from 1 to 1000, n3 is an integer selected from 11 to 1000, L1, L2 are each independently a linking group, p is 0 or 1, q is 0 or 1, R1 is a hydrogen atom or a hydrocarbon group having 1 to 20 carbon atoms, D is a bio-related substance, Z is a linking group, and Z can react with the bio-related substance to form a residue group L3. The PEG-modified bio-related substance maintains good biological activity, and has better solubility and a longer half-life in vivo.
    Type: Application
    Filed: December 21, 2013
    Publication date: July 17, 2014
    Applicant: Xiamen Sinopeg Biotech, Ltd.
    Inventors: WenGui WENG, Chao LIU, JinCheng LIAO, JinChun YUAN