Patents by Inventor Jincong Zhuo

Jincong Zhuo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLOPROTEASES
    Publication number: 20090124649
    Abstract: The present invention provides a compound of Formula I or Formula II: enantiomer, diastereomer, prodrug, solvate, metabolite, or pharmaceutically acceptable salt thereof, wherein constituent variables are provided herein. The compounds of Formula I and II are modulators of metalloproteases and are useful in treating diseases associated with metalloprotease activity such as arthritis, cancer, cardiovascular disorders, skin disorders, inflammation and allergic conditions.
    Type: Application
    Filed: December 3, 2008
    Publication date: May 14, 2009
    Applicant: INCYTE CORPORATION
    Inventors: Wenqing Yao, Jincong Zhuo, Meizhong Xu, Fenglei Zhang, Brian Metcalf
  • Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases
    Patent number: 7491724
    Abstract: The present invention provides compounds of the formula I: its enantiomers, diastereomers, racemic mixtures thereof, prodrugs, crystalline forms, non-crystalline forms, amorphous forms thereof, solvates thereof, metabolites thereof, and pharmaceutically acceptable salts, wherein the ring A substituent groups are fully defined in the following disclosure. The compounds of formula I are inhibitors of metalloproteases such as matrix metalloproteases and sheddases, and are useful in treating diseases such as rheumatoid arthritis, psoriasis, neoplastic diseases, allergies and all those diseases wherein inhibition of MMPs is desirable.
    Type: Grant
    Filed: October 15, 2004
    Date of Patent: February 17, 2009
    Assignee: Incyte Corporation
    Inventors: Yun-Long Li, Jincong Zhuo, David Burns, Wenqing Yao, Ravi Kumar Jalluri
  • SPIROCYCLES AS INHIBITORS OF 11-BETA HYDROXYL STEROID DEHYDROGENASE TYPE 1
    Publication number: 20080318991
    Abstract: The present invention relates to certain spirocyclic compounds that are inhibitors of 11-? hydroxyl steroid dehydrogenase type 1 (11?HSD1), compositions containing the same, and methods of using the same for the treatment of diabetes, obesity and other diseases.
    Type: Application
    Filed: June 20, 2008
    Publication date: December 25, 2008
    Applicant: INCYTE CORPORATION
    Inventors: Wenqing Yao, Jincong Zhuo, Colin Zhang
  • Amido Compounds And Their Use As Pharmaceuticals
    Publication number: 20080255154
    Abstract: The present invention relates to inhibitors of 11-? hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-? hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
    Type: Application
    Filed: June 10, 2008
    Publication date: October 16, 2008
    Applicant: INCYTE CORPORATION
    Inventors: Wenqing Yao, Jincong Zhuo, Meizhong Xu, Brian W. Metcalf, Chunhong He, Ding-Quan Qian, Colin Zhang
  • Substituted cyclic hydroxamates as lnhibitors of matrix metalloproteinases
    Publication number: 20080167288
    Abstract: The present invention provides compounds of the formula: its enantiomers, diastereomers, racemic mixtures thereof, prodrugs, crystalline forms, non-crystalline forms, amorphous forms thereof, solvates thereof, metabolites thereof, and pharmaceutically acceptable salts, wherein the ring A substituent groups are fully defined in the following disclosure. The compounds of formula are inhibitors of metalloproteases such as matrix metalloproteases and sheddases, and are useful in treating diseases such as rheumatoid arthritis, psoriasis, neoplastic diseases, allergies and all those diseases wherein inhibition of MMPs is desirable.
    Type: Application
    Filed: February 15, 2008
    Publication date: July 10, 2008
    Applicant: Lncyte Corporation
    Inventors: Yun Long Li, Jincong Zhuo, David Burns, Wanqing Yao, Ravi Kumar Jalluri
  • IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS
    Publication number: 20080167287
    Abstract: The present invention is directed to imidazo[1,2-b][1,2,4]triazines and imidazo[1,2-a]pyrimidines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways.
    Type: Application
    Filed: November 19, 2007
    Publication date: July 10, 2008
    Applicant: INCYTE CORPORATION
    Inventors: Jincong Zhuo, Meizhong Xu, Chunhong He, Colin Zhang, Ding-Quan Qian, David M. Burns, Yun-Long Li, Brian Metcalf, Wenqing Yao
  • TRIAZOLOTRIAZINES AS KINASE INHIBITORS
    Publication number: 20080039457
    Abstract: The present invention is directed to [1,2,4]triazolo[4,3-b][1,2,4]triazines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways.
    Type: Application
    Filed: August 6, 2007
    Publication date: February 14, 2008
    Applicant: INCYTE CORPORATION
    Inventors: Jincong Zhuo, Colin Zhang, Meizhong Xu, Ding-Quan Qian, Wenqing Yao, Ravi Jalluri
  • Amido compounds and their use as pharmaceuticals
    Patent number: 7304081
    Abstract: The present invention relates to inhibitors of 11-? hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-? hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
    Type: Grant
    Filed: May 4, 2005
    Date of Patent: December 4, 2007
    Assignee: Incyte Corporation
    Inventors: Wenqing Yao, Jincong Zhuo, Meizhong Xu, Brian W. Metcalf, Chunhong He, Ding-Quan Qian, Colin Zhang
  • Heterocyclic inhibitors of 11-beta hydroxyl steroid dehydrogenase type 1 and methods of using the same
    Publication number: 20070270424
    Abstract: The present invention relates to inhibitors of 11-? hydroxyl steroid dehydrogenase type 1 and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-? hydroxyl steroid dehydrogenase type 1.
    Type: Application
    Filed: May 16, 2007
    Publication date: November 22, 2007
    Inventors: Yun-Long Li, Jincong Zhuo, Wenqing Yao
  • Modulators of 11- beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
    Publication number: 20070208001
    Abstract: The present invention relates to inhibitors of 11-? hydroxyl steroid dehydrogenase type 1 and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-? hydroxyl steroid dehydrogenase type 1.
    Type: Application
    Filed: March 1, 2007
    Publication date: September 6, 2007
    Inventors: Jincong Zhuo, Yun-Long Li, Meizhong Xu, Chunhong He, Wenqing Yao
  • Modulators of 11-beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
    Publication number: 20070197506
    Abstract: The present invention relates to inhibitors of 11-? hydroxyl steroid dehydrogenase type 1 and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-? hydroxyl steroid dehydrogenase type 1 such as obesity and diabetes.
    Type: Application
    Filed: January 11, 2007
    Publication date: August 23, 2007
    Inventors: Wenqing Yao, David Burns, Lihua Chen, Jincong Zhuo, Chunhong He
  • Amido compounds and their use as pharmaceuticals
    Publication number: 20070197530
    Abstract: The present invention relates to inhibitors of 11-? hydroxyl steroid dehydrogenase type 1 and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-? hydroxyl steroid dehydrogenase type 1.
    Type: Application
    Filed: January 30, 2007
    Publication date: August 23, 2007
    Inventors: Yun-Long Li, Wenqing Yao, Jincong Zhuo
  • Amido compounds and their use as pharmaceuticals
    Publication number: 20070179142
    Abstract: The present invention relates to inhibitors of 11-? hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-? hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
    Type: Application
    Filed: April 6, 2007
    Publication date: August 2, 2007
    Inventors: Wenqing Yao, Jincong Zhuo, Meizhong Xu, Brian Metcalf, Chunhong He, Ding-Quan Qian, Colin Zhang
  • Lactam compounds and methods of using the same
    Publication number: 20070129345
    Abstract: The present invention relates to inhibitors of 11-? hydroxyl steroid dehydrogenase type 1 and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-? hydroxyl steroid dehydrogenase type 1.
    Type: Application
    Filed: December 4, 2006
    Publication date: June 7, 2007
    Inventors: Jincong Zhuo, Ding-Quan Qian, Wenqing Yao
  • Amido compounds and their use as pharmaceuticals
    Publication number: 20070066584
    Abstract: The present invention relates to inhibitors of 11-? hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-? hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
    Type: Application
    Filed: September 20, 2006
    Publication date: March 22, 2007
    Inventors: Wenqing Yao, Jincong Zhuo, Ding-Quan Qian
  • Amido compounds and their use as pharmaceuticals
    Publication number: 20060122197
    Abstract: The present invention relates to inhibitors of 11-? hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-? hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
    Type: Application
    Filed: August 9, 2005
    Publication date: June 8, 2006
    Inventors: Wenqing Yao, Jincong Zhuo, Brian Metcalf, Ding-Quan Qian, Yanlong Li
  • Lactam compounds and their use as pharmaceuticals
    Publication number: 20060116382
    Abstract: The present invention relates to inhibitors of 11-? hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-? hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
    Type: Application
    Filed: November 9, 2005
    Publication date: June 1, 2006
    Inventors: Wenqing Yao, Chunghong He, Jincong Zhuo, Meizhong Xu, Colin Zhang, Ding-Quan Qian, David Burns, Brian Metcalf
  • Amido compounds and their use as pharmaceuticals
    Publication number: 20060009491
    Abstract: The present invention relates to inhibitors of 11-? hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-? hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
    Type: Application
    Filed: June 23, 2005
    Publication date: January 12, 2006
    Inventors: Wenqing Yao, Colin Zhang, Konstantinos Agrios, Brian Metcalf, Jincong Zhuo
  • Amido compounds and their use as pharmaceuticals
    Publication number: 20060009471
    Abstract: The present invention relates to inhibitors of 11-? hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-? hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
    Type: Application
    Filed: June 23, 2005
    Publication date: January 12, 2006
    Inventors: Wenqing Yao, Meizhong Xu, Colin Zhang, Konstantinos Agrios, Brian Metcalf, Jincong Zhuo
  • N-substituted piperidines and their use as pharrmaceuticals
    Publication number: 20060004049
    Abstract: The present invention relates to inhibitors of 11-? hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-? hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
    Type: Application
    Filed: June 23, 2005
    Publication date: January 5, 2006
    Inventors: Wenqing Yao, Meizhong Xu, Colin Zhang, Yanlong Li, Jincong Zhuo, Brian Metcalf