Patents by Inventor Jinduo Yuan

Jinduo Yuan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMMOBILIZED ENDOGLYCOSIDASE FUSION PROTEIN AND USE THEREOF
    Publication number: 20240398960
    Abstract: A method for preparing an antibody-drug conjugate. The antibody-drug conjugate is formed by means of site-directed conjugation on the basis of an N-glycosylation site of an Fc region of an antibody. The method comprises: (1) providing a donor containing an oxazoline oligosaccharide, an antibody containing a GlcNAc motif, and an immobilized endoglycosidase having a glycoside transfer activity; and (2) covalently linking the activated donor containing the oxazoline oligosaccharide to the antibody containing the GlcNAc motif by means of the catalytic action of the endoglycosidase; therefore, one-step conjugation is realized. The present invention also relates to an endoglycosidase fusion protein, which comprises a covalently linked endoglycosidase, a Halo tag, and/or a His tag.
    Type: Application
    Filed: July 29, 2024
    Publication date: December 5, 2024
    Inventors: Cao LV, Jinduo YUAN, Gang QIN, Meijun XIONG
  • STABLE ANTIBODY-DRUG CONJUGATE, PREPARATION METHOD THEREFOR, AND USE THEREOF
    Publication number: 20240165192
    Abstract: The present invention provides a conjugate and preparation method thereof, a pharmaceutical composition comprising the conjugate and use of the pharmaceutical composition in the manufacture of a medicament for the treatment or prevention of a disease.
    Type: Application
    Filed: January 11, 2024
    Publication date: May 23, 2024
    Inventors: Gang QIN, Jinduo YUAN, Lu JIANG, Chubing TAN, Lili SHI, Cao LV, Leilei CHEN
  • STABLE ANTIBODY-DRUG CONJUGATE, PREPARATION METHOD THEREFOR, AND USE THEREOF
    Publication number: 20240156894
    Abstract: The present invention provides a conjugate and preparation method thereof, a pharmaceutical composition comprising the conjugate and use of the pharmaceutical composition in the manufacture of a medicament for the treatment or prevention of a disease.
    Type: Application
    Filed: January 10, 2024
    Publication date: May 16, 2024
    Inventors: Gang QIN, Jinduo YUAN, Lu JIANG, Chubing TAN, Lili SHI, Cao LV, Leilei CHEN
  • Stable antibody-drug conjugate, preparation method therefor, and use thereof
    Patent number: 11911434
    Abstract: The present invention provides a conjugate and preparation method thereof, a pharmaceutical composition comprising the conjugate and use of the pharmaceutical composition in the manufacture of a medicament for the treatment or prevention of a disease.
    Type: Grant
    Filed: February 19, 2021
    Date of Patent: February 27, 2024
    Assignee: GENEQUANTUM HEALTHCARE (SUZHOU) CO., LTD.
    Inventors: Gang Qin, Jinduo Yuan, Lu Jiang, Chubing Tan, Lili Shi, Cao Lv, Leilei Chen
  • Stable antibody-drug conjugate, preparation method therefor, and use thereof
    Patent number: 11911435
    Abstract: A conjugate and preparation method therefor, comprising a medication composition comprising the conjugate and a use of the medication composition in preparing medications for the treatment or prevention of diseases.
    Type: Grant
    Filed: February 19, 2021
    Date of Patent: February 27, 2024
    Assignee: GENEQUANTUM HEALTHCARE (SUZHOU) CO., LTD.
    Inventors: Gang Qin, Jinduo Yuan, Lu Jiang, Chubing Tan, Lili Shi, Cao Lv, Leilei Chen
  • A DRUG CONJUGATE AND APPLICATIONS THEREOF
    Publication number: 20230256108
    Abstract: A linker molecule for targeting molecule-drug conjugate, has the structure of formula (I): A1p-D1q-Y-Lk-W-A2q-D2p (I). A conjugate has the structure of formula (III): A-((compound of formula (1))-PL t) z (III). The conjugate can be used in the manufacture of a medicament for treating a disease.
    Type: Application
    Filed: December 31, 2020
    Publication date: August 17, 2023
    Inventors: Gang QIN, Lu JIANG, Lili SHI, Jinduo YUAN, Chong LIU, Lehua HU
  • STABLE ANTIBODY-DRUG CONJUGATE, PREPARATION METHOD THEREFOR, AND USE THEREOF
    Publication number: 20210401924
    Abstract: The present invention provides a conjugate and preparation method thereof, a pharmaceutical composition comprising the conjugate and use of the pharmaceutical composition in the manufacture of a medicament for the treatment or prevention of a disease.
    Type: Application
    Filed: February 19, 2021
    Publication date: December 30, 2021
    Inventors: Gang Qin, Jinduo Yuan, Lu Jiang, Chubing Tan, Lili Shi, Cao Lv, Leilei Chen
  • Stable antibody-drug conjugate, preparation method therefor, and use thereof
    Patent number: 11040084
    Abstract: The present invention provides a conjugate and preparation method thereof, a pharmaceutical composition comprising the conjugate and use of the pharmaceutical composition in the manufacture of a medicament for the treatment or prevention of a disease.
    Type: Grant
    Filed: April 29, 2015
    Date of Patent: June 22, 2021
    Assignee: GENEQUANTUM HEALTHCARE (SUZHOU) CO., LTD.
    Inventors: Gang Qin, Jinduo Yuan, Lu Jiang, Chubing Tan, Lili Shi, Cao Lv, Leilei Chen
  • NEW STABLE ANTIBODY-DRUG CONJUGATE, PREPARATION METHOD THEREFOR, AND USE THEREOF
    Publication number: 20210177929
    Abstract: A conjugate and preparation method therefor, comprising a medication composition comprising the conjugate and a use of the medication composition in preparing medications for the treatment or prevention of diseases.
    Type: Application
    Filed: February 19, 2021
    Publication date: June 17, 2021
    Applicant: GENEQUANTUM HEALTHCARE (SUZHOU) CO., LTD.
    Inventors: Gang Qin, Jinduo Yuan, Lu Jiang, Chubing Tan, Lili Shi, Cao Lv, Leilei Chen
  • STABLE ANTIBODY-DRUG CONJUGATE, PREPARATION METHOD THEREFOR, AND USE THEREOF
    Publication number: 20170112944
    Abstract: The present invention provides a conjugate and preparation method thereof, a pharmaceutical composition comprising the conjugate and use of the pharmaceutical composition in the manufacture of a medicament for the treatment or prevention of a disease.
    Type: Application
    Filed: April 29, 2015
    Publication date: April 27, 2017
    Inventors: Gang Qin, Jinduo Yuan, Lu Jiang, Chubing Tan, Lili Shi, Cao Lv, Leilei Chen