Patents by Inventor Jinfa Du

Jinfa Du has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20100016251
    Abstract: Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.
    Type: Application
    Filed: March 21, 2008
    Publication date: January 21, 2010
    Applicant: PHARMASSET, INC.
    Inventors: MICHAEL JOSEPH SOFIA, JINFA DU, PEIYUAN WANG, DHANAPALAN NAGARATHNAM
  • Publication number: 20090318380
    Abstract: Embodiments of the invention are to compounds, methods, and compositions for use in the treatment of viral infections. More specifically embodiments of the invention are 2?,4?-substituted nucleoside compounds useful for the treatment of viral infections, such as HIV, HCV, and HBV infections.
    Type: Application
    Filed: November 14, 2008
    Publication date: December 24, 2009
    Applicant: PHARMASSET, INC.
    Inventors: MICHAEL JOSEPH SOFIA, JINFA DU
  • Patent number: 7601820
    Abstract: The present invention provides (i) a process for preparing a 2-deoxy-2-fluoro-2-methyl-D-ribonolactone derivative, (ii) conversion of the lactone to nucleosides with potent anti-HCV activity, and their analogues, and (iii) a method to prepare the anti-HCV nucleosides containing the 2-deoxy-2-fluoro-2-C-methyl-?-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.
    Type: Grant
    Filed: February 13, 2006
    Date of Patent: October 13, 2009
    Assignee: Pharmasset, Inc.
    Inventors: Peiyuan Wang, Wojciech Stec, Byoung-Kwon Chun, Junxing Shi, Jinfa Du
  • Publication number: 20090099136
    Abstract: Disclosed are dioxolane thymine phosphoramidate compounds, compositions, and methods for using dioxolane thymine phosphoramidate compounds and compositions to treat viral infections, such as HIV infections.
    Type: Application
    Filed: October 15, 2008
    Publication date: April 16, 2009
    Applicant: PHARMASSET, INC.
    Inventors: MICHAEL JOSEPH SOFIA, PEIYUAN WANG, SUGUNA H. RACHAKONDA, JINFA DU
  • Publication number: 20060199783
    Abstract: The present invention provides (i) a process for preparing a 2-deoxy-2-fluoro-2-methyl-D-ribonolactone derivative, (ii) conversion of the lactone to nucleosides with potent anti-HCV activity, and their analogues, and (iii) a method to prepare the anti-HCV nucleosides containing the 2-deoxy-2-fluoro-2-C-methyl-o-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.
    Type: Application
    Filed: February 13, 2006
    Publication date: September 7, 2006
    Applicant: Pharmassett, Inc.
    Inventors: Peiyuan Wang, Wojciech Stec, Byoung-Kwon Chun, Junxing Shi, Jinfa Du
  • Patent number: 6949521
    Abstract: Pharmaceutical prodrug compositions are provided comprising azide derivatives of drugs which are capable of being converted to the drug in vivo. Azide derivatives of drugs having amine, ketone and hydroxy substituents are converted in vivo to the corresponding drugs, increasing the half-life of the drugs. In addition azide prodrugs are often better able to penetrate the blood-brain barrier than the corresponding drugs. Especially useful are azide derivatives of cordycepin, 2?-F-ara-ddI, AraA, acyclovir, penciclovir and related drugs. Useful azide prodrugs are azide derivatives of therapeutic alicyclic amines, ketones, and hydroxy-substituted compounds, including aralkyl, heterocyclic aralkyl, and cyclic aliphatic compounds, where the amine or oxygen moiety is on the ring, or where the amine or oxygen moiety is on an aliphatic side chain, as well as therapeutic purines and pyrimidines, nucleoside analogs and phosphorylated nucleoside analogs.
    Type: Grant
    Filed: May 4, 2001
    Date of Patent: September 27, 2005
    Assignees: The University of Georgia Research Foundation, Inc., Emory University
    Inventors: Chung K. Chu, Lakshmi P. Kotra, Konstantine Manouilov, Jinfa Du, Raymond Schinazi
  • Patent number: 6894159
    Abstract: The present invention relates to a novel and improved process for preparing 2?-fluoro-5-methyl-?-L-arabinofuranosyluridine represented by formula (1) which shows anti-viral activity, especially potent anti-viral activity against hepatitis B-virus and Epstein-Barr virus:
    Type: Grant
    Filed: January 24, 2003
    Date of Patent: May 17, 2005
    Assignee: The University of Georgia Research Foundation
    Inventors: Chung K. Chu, Jinfa Du, Yongseok Choi
  • Patent number: 6855821
    Abstract: Disclosed are novel processes for preparing 1,3-dioxolane nucleosides of general formula I and II: wherein B is a purine or pyrimidine base or an analog or derivative thereof. The invention also provides intermediates for use in the preparation of these compounds.
    Type: Grant
    Filed: August 6, 2003
    Date of Patent: February 15, 2005
    Assignee: Pharmasset, Ltd.
    Inventors: Jinfa Du, Kyoichi A. Watanabe
  • Publication number: 20040087806
    Abstract: Disclosed are novel processes for preparing 1,3-dioxolane nucleosides of general formula I and II: 1
    Type: Application
    Filed: August 6, 2003
    Publication date: May 6, 2004
    Inventors: Jinfa Du, Kyoichi A. Watanabe
  • Publication number: 20030162992
    Abstract: The present invention is an efficient process for the manufacture of &agr;-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.
    Type: Application
    Filed: December 12, 2002
    Publication date: August 28, 2003
    Inventors: Kyoichi A. Watanabe, Jinfa Du
  • Publication number: 20030139593
    Abstract: The present invention relates to a novel and improved process for preparing 2′-fluoro-5-methyl-&bgr;-L-arabinofuranosyluridine represented by formula (1) which shows anti-viral activity, especially potent anti-viral activity against hepatitis B-virus and Epstein-Barr virus: 1
    Type: Application
    Filed: January 24, 2003
    Publication date: July 24, 2003
    Applicant: University of Georgia Research Foundation Inc.
    Inventors: Chung K. Chu, Jinfa Du, Yongseok Choi
  • Patent number: 6590107
    Abstract: A method and composition for the treatment of HIV infection, HBV infection, or abnormal cellular proliferation in humans and other host animals is disclosed that includes the administration of an effective amount of a 1,3-oxaselenolane nucleoside or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: March 5, 2001
    Date of Patent: July 8, 2003
    Assignees: Emory University, The University of Georgia Research Foundation, Inc.
    Inventors: Raymond F. Schinazi, Chung K. Chu, Jinfa Du
  • Patent number: 6512107
    Abstract: The present invention relates to a novel and improved process for preparing 2′-fluoro-5-methyl-&bgr;-L-arabinofuranosyluridine represented by formula (I) which shows anti-viral activity, especially potent anti-viral activity against hepatitis B-virus and Epstein-Barr virus:
    Type: Grant
    Filed: July 23, 1998
    Date of Patent: January 28, 2003
    Assignee: The University of Georgia Research Foundation
    Inventors: Chung K. Chu, Jinfa Du, Yongseok Choi
  • Publication number: 20020062018
    Abstract: The present invention relates to a novel and improved process for preparing 2′-fluoro-5-methyl-&bgr;-L-arabinofuranosyluridine represented by formula (1) which shows anti-viral activity, especially potent anti-viral activity against hepatitis B-virus and Epstein-Barr virus: 1
    Type: Application
    Filed: July 23, 1998
    Publication date: May 23, 2002
    Inventors: CHUNG K. CHU, JINFA DU, YONGSEOK CHOI
  • Publication number: 20010036930
    Abstract: Pharmaceutical prodrug compositions are provided comprising azide derivatives of drugs which are capable of being converted to the drug in vivo. Azide derivatives of drugs having amine, ketone and hydroxy substituents are converted in vivo to the corresponding drugs, increasing the half-life of the drugs. In addition azide prodrugs are often better able to penetrate the blood-brain barrier than the corresponding drugs. Especially useful are azide derivatives of cordycepin, 2′-F-ara-ddI, AraA, acyclovir, penciclovir and related drugs. Useful azide prodrugs are azide derivatives of therapeutic alicyclic amines, ketones, and hydroxy-substituted compounds, including aralkyl, heterocyclic aralkyl, and cyclic aliphatic compounds, where the amine or oxygen moiety is on the ring, or where the amine or oxygen moiety is on an aliphatic side chain, as well as therapeutic purines and pyrimidines, nucleoside analogs and phosphorylated nucleoside analogs.
    Type: Application
    Filed: May 4, 2001
    Publication date: November 1, 2001
    Applicant: University of Georgia Research Foundation, Inc.
    Inventors: Chung K. Chu, Lakshmi P. Kotra, Konstantine K. Manouilov, Jinfa Du, Raymond Schinazi
  • Patent number: 6271212
    Abstract: Pharmaceutical prodrug compositions are provided comprising azide derivatives of drugs which are capable of being converted to the drug in vivo. Azide derivatives of drugs having amine, ketone and hydroxy substituents are converted in vivo to the corresponding drugs, increasing the half-life of the drugs. In addition azide prodrugs are often better able to penetrate the blood-brain barrier than the corresponding drugs. Especially useful are azide derivatives of cordycepin, 2′-F-ara-ddI, AraA, acyclovir, penciclovir and related drugs. Useful azide prodrugs are azide derivatives of therapeutic alicyclic amines, ketones, and hydroxy-substituted compounds, including aralkyl, heterocyclic aralkyl, and cyclic aliphatic compounds, where the amine or oxygen moiety is on the ring, or where the amine or oxygen moiety is on an aliphatic side chain, as well as therapeutic purines and pyrimidines, nucleoside analogs and phosphorylated nucleoside analogs.
    Type: Grant
    Filed: March 3, 1998
    Date of Patent: August 7, 2001
    Assignees: University of Georgia Research Foundation Inc., Emory University
    Inventors: Chung K. Chu, Lakshimi Kotra, Kostantine K. Manouilov, Jinfa Du, Raymond Schinazi
  • Publication number: 20010011146
    Abstract: The present invention relates to a compound having the formula: 1
    Type: Application
    Filed: April 23, 1998
    Publication date: August 2, 2001
    Inventors: TONG H. JOH, SUNGHEE CHO, CHUNG K. CHU, JINFA DU
  • Patent number: 6197777
    Abstract: A method and composition for the treatment of HIV infection, HBV infection, or abnormal cellular proliferation in humans and other host animals is disclosed that includes the administration of an effective amount of a 1,3-oxaselenolane nucleoside or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: March 6, 2001
    Assignees: Emory University, The University of Georgia Research Foundation, Inc.
    Inventors: Raymond F. Schinazi, Chung K. Chu, Jinfa Du
  • Patent number: 6071922
    Abstract: A method and composition for the treatment of HIV infection, HBV infection, or abnormal cellular proliferation in humans and other host animals is disclosed that includes the administration of an effective amount of a 1,3-oxaselenolane nucleoside or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: March 19, 1998
    Date of Patent: June 6, 2000
    Assignees: Emory University, The University of Georgia Research Foundation, Inc.
    Inventors: Raymond F. Schinazi, Chung K. Chu, Jinfa Du
  • Patent number: 5648489
    Abstract: A method is provided for the synthesis of synthesis of acyclic purine nucleosides, particularly 9-(2-hydroxy-ethoxymethyl)-guanine (acyclovir) and 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine ("DHPG") where the N.sup.2,N.sup.9 -diprotected guanine is reacted with CH.sub.3 C(O)OCH.sub.2 O(CH.sub.2).sub.2)OC(O)CH.sub.3 or 2-acetoxymethoxy-1,3-diacetoxypropane, respectively, in the presence of a mixture of an acid and acetic anhydride, or in the presence of an acid, where the acid can be phosphoric acid or polyphosphoric acid.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 15, 1997
    Assignee: University of Georgia Research Foundation
    Inventors: Chung K. Chu, Jinfa Du, Chunguang Wang