Abstract: The invention regards a composite for environmental remediation, comprising: —one or more green rust compound(s) or green rust precursor(s), and—one or more biochar(s).

Abstract: A method for tapping a yield potential of Saccharum officinarum by controlling a time of plastic mulching is provided. The method includes: (1) plastic mulching: mulching a Saccharum officinarum furrow in a Saccharum officinarum field fully with a wide plastic film in a direction parallel to the Saccharum officinarum furrow, and covering the plastic film directly above the Saccharum officinarum furrow with soil with a certain thickness along the Saccharum officinarum furrow, such that the plastic film is tightly attached to soil in the Saccharum officinarum furrow; (2) control of the time of plastic mulching, and (3) plastic film recycling treatment. The method of the present disclosure is advanced, practical, easy to operate, and easy to promote.

Abstract: Provided in the present invention are a substituted amino six-membered nitric heterocyclic ring compound and a preparation and use thereof. In particular, provided in the present invention is a compound as shown by general formula (I) below, wherein the definition of each group is as described in the description. The compound of the present invention has an excellent tyrosine kinase inhibitory activity, and can thus be used to prepare a series of medicines for treating diseases related to tyrosine kinase inhibitory activity.

Abstract: Use of a compound of general formula (A) which is a CFS-1R kinase inhibitor or a pharmaceutically acceptable salt thereof in the preparation of medicaments for treating diseases related to CSF-1R kinase signal transduction pathway or medicaments for regulating immunization. In vivo and in vitro studies show that the compound can significantly inhibit CSF-1R kinase activity; significantly inhibits the proliferation of a CSF-1/CSF-1R-driven mouse myeloid leukemia cell line, inhibits the survival of macrophages induced by CSF-1 and reverses M2 polarization phenotype of macrophages, and has an effect superior to that of the marketed medicament Pexidartinib. In a TAM enriched tumor model (MC38 model), the compound significantly antagonizes the tumor immunosuppressive microenvironment and exhibits significant anti-tumor efficacy.

Abstract: The present disclosure relates to a fused ring pyrimidine amino compound and a preparation method, a pharmaceutical composition, and a use thereof. Specifically disclosed in the present disclosure are the compound shown in formula I, a pharmaceutically acceptable salt thereof, a tautomer thereof, a stereoisomer thereof, a metabolite thereof, a metabolic precursor thereof, or a prodrug thereof. The fused ring pyrimidine amino compound of the present application has good inhibitory activity against DDRs, particularly DDR2, and has a good therapeutic effect on tumors and fibrotic diseases, especially pulmonary inflammation and pulmonary fibrosis. Also disclosed in the present disclosure are a preparation method for the compound shown in formula I, and a use thereof.

Abstract: The present invention relates to a method for acquiring the water leakage amount of a leakage area in a water distribution system. In the method, a hydraulic model is coupled with monitored data, and the water leakage amounts of different areas in the water distribution system are obtained through inversion by optimizing the spatial distribution of water leakage amounts. In addition to the coupling of the hydraulic model with the monitored data, virtual sectorization and pipe leakage risk assessment are used. By using a minimum difference between a simulated value and a monitored value at a pressure measurement point as a target, the water leakage amounts of different areas in the water distribution system are calculated by an optimization algorithm. Compared with the prior art, the present invention actualizes the effective identification of leakage areas in a water distribution system with a high leakage rate (i.e., with many leakage points).

Abstract: A compound having Axl and c-Met kinase inhibitory activity, a preparation method therefor and an application thereof are provided. Specifically, provided herein are a compound having the structure represented by formula (I), a preparation method therefor and an application thereof in the preparation of a medication for the treatment and/or prevention of tumor-associated diseases and/or kinase-related diseases.

Abstract: The present disclosure relates to a fused ring pyrimidine amino compound and a preparation method, a pharmaceutical composition, and a use thereof. Specifically disclosed in the present disclosure are the compound shown in formula I, a pharmaceutically acceptable salt thereof, a tautomer thereof, a stereoisomer thereof, a metabolite thereof, a metabolic precursor thereof, or a prodrug thereof. The fused ring pyrimidine amino compound of the present application has good inhibitory activity against DDRs, particularly DDR2, and has a good therapeutic effect on tumors and fibrotic diseases, especially pulmonary inflammation and pulmonary fibrosis. Also disclosed in the present disclosure are a preparation method for the compound shown in formula I, and a use thereof.

Abstract: The present invention relates to an adjustable dumbbell, which includes a dumbbell body and dumbbell pieces cumulatively attached to both ends of the dumbbell body, wherein the dumbbell body includes a grip rod and mounting portions, further includes a first telescopic rod and a second telescopic rod, the number of dumbbell pieces hanging on the first telescopic rod and the second telescopic rod is controlled by the first telescopic rod and the second telescopic rod extending from or retracting into both ends of the dumbbell body in opposite directions, thereby adjusting the weight of dumbbells. The first telescopic rod and the second telescopic rod are disposed in a semicircular shaft shape, and the first telescopic rod and the second telescopic rod are staggered, so that the lengths of the first telescopic rod and the second telescopic rod are doubled, and the number of adjustable dumbbell pieces is greatly increased.

Abstract: The present invention relates to a fast-adjusting dumbbell, comprising a dumbbell body and dumbbell pieces cumulatively attached to both ends of the dumbbell body. The dumbbell body includes a grip rod, a planetary gear system, and a telescopic rod. The grip rod is rotated and drives the planetary gear system to realize the expansion and contraction of the telescopic rod, thereby adjusting the number of dumbbell pieces, which is convenient to operate and easy to implement. Both ends of the grip rod are assembled with flange driving members, the planetary gear system includes an outer casing, through the installation mode that the flange driving member is engaged with the planetary gear system, the planetary gear mechanism is disposed enclosedly, and a load-bearing iron ring is also disposed in the planetary gear system to play a load-bearing and limiting effect on the planetary carrier.

Abstract: The present invention relates to an adjustable dumbbell, which includes a rotatably disposed grip rod and a locking element, wherein a locking portion is disposed at both ends of the grip rod, the locking element includes a base, a movable pin and a compression spring, the movable pin is slidably disposed in the base, the base is provided with a first spring sleeve column, the movable pin is provided with a second spring sleeve column, and both ends of the compression spring are respectively sleeved and positioned on the first spring sleeve column and the second spring sleeve column. In the present invention, the base and the movable pin are both provided with the spring sleeve column, which is not only convenient to mount and position the compression spring during assembly, but also can prevent the compression spring from falling out due to the shaking of dumbbells in use.

Abstract: The present invention relates to a dumbbell and especially relates to an improvement on an assembly mode of a grip rod and flanges at both ends thereof in the dumbbell. The present invention axially positions the grip rod and the flange by the assembly of the first assembly groove in an L shape on the grip rod and the positioning block on the flange, then circumferentially positions the grip rod and the flange by plugging a positioning pin in the first assembly groove of the grip rod and the second assembly groove of the flange simultaneously, in cooperation with the shaft-hole fitting of the grip rod and the flange themselves, thereby implementing screw-free installation of the grip rod and the flange, simple manufacturing, a low cost and a high installation efficiency.

Abstract: The invention regards a composite for environmental remediation, comprising: —one or more green rust compound(s) or green rust precursor(s), and—one or more biochar(s).

Abstract: The invention relates to the field of pharmaceutical chemistry. Specifically, the present invention relates to a series of BET (bromodomain and extra-terminal domain) inhibitors having a novel structure, particularly inhibitors targeting BRD4 (Bromodomain-containing protein 4), and a preparation method and use therefor. The structure thereof is shown in the following general formula (I). Said compounds or a stereoisomer, racemate, geometric isomer, tautomer, prodrug, hydrate, solvate, or crystal form thereof, or a pharmaceutically acceptable salt thereof, and the pharmaceutical composition thereof can be used for the treatment and/or prevention of related diseases mediated by bromodomain proteins.

Abstract: Provided are a class of fused-cyclic pyrazolone formamide compounds and a preparation method therefor, a pharmaceutical composition and the use thereof. Specifically, provided is a compound having the structure as shown in formula (I) (with each group defined in the description). The compound can be used as an AXL inhibitor in the preparation of a pharmaceutical composition for treating tumors.

Abstract: An o-aminoheteroaryl alkynyl-containing compound has a structure represented by formula (I), and the compound of formula (I) has advantages of a high FGFR and RET double target inhibitory activity and a relatively low KDR activity, and the compound of formula (I) exhibits a strong inhibitory activity in a human lung cancer cell line NCI-H1581 and a gastric cancer cell line SNU16 as well as an RET-dependent sensitive cell line BaF3-CCDC6-Ret and a mutant thereof. Pharmacokinetic data shows that the o-aminoheteroaryl alkynyl-containing compound has druggability, and exhibits significant relevant inhibition of the growth of related tumors in a long-term animal model of drug efficacy and results in favorable animal condition at effective doses.

Abstract: The present invention relates to quinoline or quinazoline compound represented by the formula (I), a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a prodrug molecule thereof, or a deuterated compound thereof. The compound of the present invention is effective in inhibiting the action of AXL protein kinase and can inhibit proliferation, migration, and invasion of various tumor cells. Further, the quinoline or quinazoline compound of the present invention has excellent metabolic stability, high in vivo antitumor activity, low toxic side effects, and can be used for preparing a drug for preventing hyperproliferative diseases such as tumors in humans and other mammals.

Abstract: The present invention relates to a method for acquiring the water leakage amount of a leakage area in a water distribution system. In the method, a hydraulic model is coupled with monitored data, and the water leakage amounts of different areas in the water distribution system are obtained through inversion by optimizing the spatial distribution of water leakage amounts. In addition to the coupling of the hydraulic model with the monitored data, virtual sectorization and pipe leakage risk assessment are used. By using a minimum difference between a simulated value and a monitored value at a pressure measurement point as a target, the water leakage amounts of different areas in the water distribution system are calculated by an optimization algorithm. Compared with the prior art, the present invention actualizes the effective identification of leakage areas in a water distribution system with a high leakage rate (i.e., with many leakage points).

Abstract: The present invention discloses a pyrido-azacyclic compound represented by formula I, an isomer thereof, a pharmaceutically acceptable salt or a pharmaceutically acceptable solvate thereof, a preparation process thereof and a composition comprising the compound, and a use thereof as a multi-target protein kinase inhibitor in the preparation of a medicament for the treatment of diseases that are associated with protein kinase, especially c-Met, such as cancer and the like. The compound represented by formula I has potent inhibitory activity on tumor cells with overexpression of c-Met kinase, can effectively target c-Met-mediated signaling pathway, and can be used in the treatment of diseases such as cancer and the like that is caused by the overexpression of c-Met kinase.

Abstract: Provided are a substituted quinolone derivative as shown by formula (I), or a pharmaceutically acceptable salt and a prodrug molecule thereof, and a pharmaceutical composition thereof, as well as the use of same in preparing drugs for the prevention and treatment of a tumor. The quinolone derivative, salt, prodrug molecule, and pharmaceutical composition thereof can be used as a protein kinase inhibitor, which is effective in inhibiting the activity of AXL protein kinase, and is capable of inhibiting the proliferation, migration and invasion of various tumor cells; and can be used in the preparation of anti-tumor drugs, especially drugs for treating hyperproliferative diseases such as a tumor in human beings and other mammals.