Abstract: The present invention relates to a primer-probe composition, a kit, and a detection method. The primer-probe composition is selected from one group of group (i) to group (ix), and the kit comprises the primer-probe composition. According to the present invention, the detection of AKR1C3 RNA content in an ex vivo sample of a patient can be achieved.

Abstract: Provided are an ionizable lipid compound of formula I for nucleic acid delivery and an LNP composition thereof, which can efficiency and stably deliver a biologically active substance to a target cell or an organ. The mRNA LNP prepared by using the lipid compound as a cationic lipid has better stability and transfection efficiency, and can cause a higher specific antibody response in an experimental animal body.

Abstract: Provided are a polyol-modified lipid compound, a preparation method therefor and an application thereof. The lipid compound and lipid nanoparticles prepared therefrom can target and effectively deliver biologically active substances to target cells and sites, and efficiently achieve pharmacological effects of the biologically active substances. In addition, the lipid compound has a singular molecular weight, which is beneficial for controlling differences between batches, improving the stability of finished drugs, and reducing immunogenicity; it is expected to be used for the development and application of related drugs.

Abstract: Disclosed herein is a method of manufacturing a non-polar volatile organic chemical sensor, the method requiring the steps of providing a composite material comprising a substrate coated by an activated Ti3C2 MXene layer, which activated Ti3C2 MXene layer has a surface and forming a hydrophobic silane layer on the surface of the activated Ti3C2 MXene layer to provide the non-polar volatile organic chemical sensor, where the hydrophobic silane layer is formed by gaseous phase silanization using a monomeric hydrophobic silane compound. Also disclosed herein is a non-polar volatile organic chemical sensor and its use to detect non-polar volatile organic compounds.

Abstract: Described is to a primer-probe composition, a kit, and a detection method. The primer-probe composition is selected from one group of group (i) to group (ix), and the kit includes the primer-probe composition. As described, the detection of AKRIC3 RNA content in an ex vivo sample of a patient can be achieved.

Abstract: An AKR1C3 detection method, and a diagnostic kit for detecting AKR1C3 and use thereof. The AKR1C3 detection method includes the following steps: treating a formalin-fixed paraffin-embedded human tissue specimen sequentially using an organic solvent, an alcohol, and water; performing antigen retrieval on the treated formalin-fixed paraffin-embedded human tissue specimen in the presence of an antigen retrieval solution; co-incubating the antigen-retrieved formalin-fixed paraffin-embedded human tissue specimen with a blocking buffer to block a non-specific antigen; mixing the blocked formalin-fixed paraffin-embedded human tissue specimen with a certain concentration of AKR1C3 monoclonal antibody solution for primary antibody incubation, and mixing the primary antibody-incubated formalin-fixed paraffin-embedded human tissue specimen with a certain concentration of a secondary antibody solution for secondary antibody incubation.

Abstract: Disclosed herein is a material suitable for the adsorption, storage and release of volatile organic compounds comprising: a porous thin film layer formed from nanosheets of one or more MXenes.

Abstract: The present application relates to metal cutting, and more particularly to a cutting fluid and a preparation method and an application thereof, especially the application in the processing of niobium-tungsten alloy (NB521). The preparation method of the cutting fluid is simple and requires low production cost. In the mechanical processing of niobium-tungsten alloy (NB521), the cutting fluid has good cooling performance, lubricity, load-bearing capacity, friction reduction and vibration absorption, and long service life. It also can effectively avoid built-up edges, thereby improving the service life of cutting tools and the processibility of materials. Therefore, products of good quality are produced to improve the yield, especially in the deep hole machining, and thus the cutting fluid of the present application is suitable for a wide range of applications.

Abstract: A stored procedure call may be transmitted to a database to execute a database query. As a result of the stored procedure call, results including a result record satisfying the database query and a set of records related to the result record may be received. The results may be stored in a local cache.

Abstract: The present application relates to metal cutting, and more particularly to a cutting fluid and a preparation method and an application thereof, especially the application in the processing of niobium-tungsten alloy (NB521). The preparation method of the cutting fluid is simple and requires low production cost. In the mechanical processing of niobium-tungsten alloy (NB521), the cutting fluid has good cooling performance, lubricity, load-bearing capacity, friction reduction and vibration absorption, and long service life. It also can effectively avoid built-up edges, thereby improving the service life of cutting tools and the processibility of materials. Therefore, products of good quality are produced to improve the yield, especially in the deep hole machining, and thus the cutting fluid of the present application is suitable for a wide range of applications.

Abstract: The present disclosure relates to a display substrate comprising a substrate; a data line disposed over the substrate; a first insulating layer disposed on the data line; a second insulating layer disposed on the first insulating layer; a first transparent electrode disposed on the second insulating layer. The present disclosure further relates to a manufacturing method of a display substrate and a display device.

Abstract: The present disclosure relates to a display substrate comprising a substrate; a data line disposed over the substrate; a first insulating layer disposed on the data line; a second insulating layer disposed on the first insulating layer; a first transparent electrode disposed on the second insulating layer. The present disclosure further relates to a manufacturing method of a display substrate and a display device.

Abstract: Polymers produced by ring opening polymerization which comprises an amino group that can be used in compositions to deliver a nucleic acid such as a miRNA or a siRNA. In some embodiments, compositions which comprise the polymers described herein and a nucleic acid are also provided herein. In some embodiments, these compositions are used to silence one or more genes in vivo or treat a disease or disorder.

Abstract: Polymers produced by ring opening polymerization which comprises an amino group that can be used in compositions to deliver a nucleic acid such as a miRNA or a siRNA. In some embodiments, compositions which comprise the polymers described herein and a nucleic acid are also provided herein. In some embodiments, these compositions are used to silence one or more genes in vivo or treat a disease or disorder.

Abstract: An exposure apparatus is provided for performing a column scan-exposure process. The exposure apparatus includes a base for supporting the exposure apparatus; and a reticle stage configured for holding a reticle having at two mask pattern regions and carrying the reticle to move reciprocally along a scanning direction. The exposure apparatus also includes a wafer stage configured for holding a wafer and carrying the wafer to move reciprocally along the scanning direction. Further, the exposure apparatus includes a control unit configured to control the reticle stage and the wafer stage to cooperatively move to cause the at least two mask pattern regions of the reticle on the reticle stage to be continuously and sequentially projected on at least two corresponding exposure shots of the wafer on the wafer stage along the scanning direction to perform a column scan-exposure process.

Abstract: A stored procedure call may be transmitted to a database to execute a database query. As a result of the stored procedure call, results including a result record satisfying the database query and a set of records related to the result record may be received. The results may be stored in a local cache.

Abstract: Polymers produced by ring opening polymerization which comprises an amino group that can be used in compositions to deliver a nucleic acid such as a miRNA or a siRNA. In some embodiments, compositions which comprise the polymers described herein and a nucleic acid are also provided herein. In some embodiments, these compositions are used to silence one or more genes in vivo or treat a disease or disorder.

Abstract: Polymers produced by ring opening polymerization which comprises an amino group that can be used in compositions to deliver a nucleic acid such as a miRNA or a siRNA. In some embodiments, compositions which comprise the polymers described herein and a nucleic acid are also provided herein. In some embodiments, these compositions are used to silence one or more genes in vivo or treat a disease or disorder.

Abstract: A method is provided in one example embodiment and includes, for each user in a subset of users subscribed to a computer-implemented matching service, determining a score for the user, the score indicating a propensity of the user to resubscribe the computer-implemented matching service; determining whether to present a save offer to the user based on the scored determined for the user; and if a determination is made to present a save offer to the user, selecting from a plurality of save offers a save offer for which the user is eligible. The method may further include determining a decile to which the user belongs based on the score determined for the user relative to scores determined for remainder of the subset of users, in which the determining whether to present a save offer to the user is based on the decile to which the user is assigned.

Abstract: An exposure apparatus is provided for performing a unidirectional scan-exposure. The exposure apparatus includes a base and a plurality of wafer stages on the base for loading/unloading wafers and successively moving from a first position to a second position of the base cyclically. The exposure apparatus also includes alignment detection units above the first position of the base for detecting alignment marks on the wafer and aligning the wafers and a cylindrical reticle system above the second position of the base. Further, the exposure apparatus includes an optical projection unit between the cylindrical reticle system and the base for projecting light onto the wafers for an exposure. Further, the exposure apparatus also includes an illuminator box and a main control unit.