Patents by Inventor Jing-Chyi Lee

Jing-Chyi Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Orthogonally protected disaccharide building blocks for synthesis of heparin
    Patent number: 7655769
    Abstract: Orthogonally protected disaccharide building blocks for synthesis of heparin saccharide are disclosed. The disaccharide building block has a formula (I), in which L is a leaving group, P1, P2, P3 and P4 are different, and of them P1 is an ester-type protecting group, P2 is a hydroxyl protecting group that could be oxidized to a carboxylic acid, P3 is a hydroxyl protecting group, and P4 is a hydroxyl protecting group which allows chemoselective deprotection with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ). Acting as an elongation unit, the disaccharide building block of formula (I) may react with a starting unit of formula (II) to synthesize a heparin saccharide of desired size.
    Type: Grant
    Filed: January 7, 2008
    Date of Patent: February 2, 2010
    Assignee: Academia Sinica
    Inventors: Shang-Cheng Hung, Jing-Chyi Lee, Xin-An Lu
  • Orthogonally protected disaccharide building blocks for synthesis of heparin oligosaccharides
    Patent number: 7582737
    Abstract: Orthogonally protected disaccharide building blocks for synthesis of heparin oligosaccharide. The disaccharide building block has a formula (I), in which L is a leaving group, P1, P2, P3 and are different, and of them P1 is an ester-type protecting group, P2 is a hydroxyl protecting group that could be oxidized to a carboxylic acid, P3 is a hydroxyl protecting group, and P4 is a hydroxyl protecting group which allows chemoslective deprotection with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ). Acting as an elongation unit, the disaccharide building block of formula (I) may react with a starting unit of formula (II) to synthesize a heparin oligosaccharide.
    Type: Grant
    Filed: July 20, 2005
    Date of Patent: September 1, 2009
    Assignee: Academia Sinica
    Inventors: Shang-Cheng Hung, Jing-Chyi Lee, Xin-An Lu
  • Heparin Oligosaccharides
    Publication number: 20080171722
    Abstract: The present invention provides composition and methods for the synthesis of low molecular weight heparins and heparinoids. The present invention also provides compositions having substantially homogenous populations of desired heparin molecules, or molecules useful in the synthesis of heparin oligosaccharides.
    Type: Application
    Filed: January 7, 2008
    Publication date: July 17, 2008
    Applicant: Academia Sinica, Office of Public Affairs (Technology Transfer)
    Inventors: Shang-Cheng Hung, Jing-Chyi Lee, Xin-An Lu
  • Heparin oligosaccharides
    Publication number: 20060079483
    Abstract: The present invention provides composition and methods for the synthesis of low molecular weight heparins and heparinoids. The present invention also provides compositions having substantially homogenous populations of desired heparin molecules, or molecules useful in the synthesis of heparin oligosaccharides.
    Type: Application
    Filed: July 20, 2005
    Publication date: April 13, 2006
    Applicant: Academia Sinica
    Inventors: Shang-Cheng Hung, Jing-Chyi Lee, Xin-An Lu