Abstract: The present invention relates to a water soluble derivative of camptothecin and preparation method thereof, the derivative having a structure of formula I and being appropriate in water solubility, and having anti-cancer activity and stability of lactonic ring. The present invention also relates to a method for synthesizing the compound and medical use of the compound.

Abstract: The present invention relates to a camptothecin derivative having a structure as represented by Formula (II), in which Xn+ is selected from H+, K+, Na+, Li+, Mg2+, Ca2+, Zn2+, Fe3+, and ammonium ion, while R1, R2, R3, and R4 independently represent a hydrogen, a hydroxyl group, a nitro group, a cyano group, a halogen, a carboxyl group, an optionally substituted amino group, a silicon-containing group, a monocyclic aryloxy group, an optionally substituted C1-C6 alkoxy group, an optionally substituted C1-C6 alkylcarbonyl group, an optionally substituted C1-C6 alkyl group, or an optionally substituted C3-C6 cycloalkyl group; alternatively, R1 and R2 are connected via one to three other atoms to form a heterocyclic ring; and in another embodiment, R3 and R4 are oxygen atoms and connected via —O—(CH2)n—O—, forming a ring, in which n=I or 2. The compound has great water-solubility, chemical stability, and great efficacy in treatment on cancer.

Abstract: Embodiments of the present application are directed to an automation process method to generate a set of wetland predictive variables using Light Detection and Ranging (“LiDAR”) data within a geographic information system (“GIS”) software platform, according to some embodiments, and to model and predict wetland in ArcGIS platform using the generated variable set. The automatic process also can run analysis on and display of the predicted wetland. The process is built by developing modules and connection in GIS. The above mentioned processes are automatically run and may just be run by one-button press, or on click, or separate buttons press, or separate clicks.

Abstract: Provided are a method and apparatus for generating and storing a database that may be searched for music upon a user's request, and a method and apparatus for searching for music corresponding to the user's request. According to an embodiment of the present invention, a plurality of melodies are divided based on phrase breaks and are stored, and a number of melodies which are similar to the user's request are detected from the stored melodies.

Abstract: The present invention relates to a water soluble derivative of camptothecin and preparation method thereof, the derivative having a structure of formula I and being appropriate in water solubility, and having anti-cancer activity and stability of lactonic ring. The present invention also relates to a method for synthesizing the compound and medical use of the compound.

Abstract: The present invention relates to a camptothecin derivative having a structure as represented by Formula (II), in which Xn+ is selected from H+, K+, Na+, Li+, Mg2+, Ca2+, Zn2+, Fe3+, and ammonium ion, while R1, R2, R3, and R4 independently represent a hydrogen, a hydroxyl group, a nitro group, a cyano group, a halogen, a carboxyl group, an optionally substituted amino group, a silicon-containing group, a monocyclic aryloxy group, an optionally substituted C1-C6 alkoxy group, an optionally substituted C1-C6 alkylcarbonyl group, an optionally substituted C1-C6 alkyl group, or an optionally substituted C3-C6 cycloalkyl group; alternatively, R1 and R2 are connected via one to three other atoms to form a heterocyclic ring; and in another embodiment, R3 and R4 are oxygen atoms and connected via —O—(CH2)n—O—, forming a ring, in which n=I or 2. The compound has great water-solubility, chemical stability, and great efficacy in treatment on cancer.

Abstract: A method and system are provided for simultaneously coupling to a plurality of client applications, receiving a first playback request from a first client application of the plurality of client applications, the first playback request being implemented in a first application specific protocol of the first client application, and a second playback request from a second client application of the plurality of client applications, the second playback request being implemented in a second application specific protocol of the second client application, wherein the first application specific protocol is different from the second application specific protocol and executing the first playback request and the second playback request by one or more players implemented in a single protocol.

Abstract: Provided are a method and apparatus for generating and storing a database that may be searched for music upon a user's request, and a method and apparatus for searching for music corresponding to the user's request. According to an embodiment of the present invention, a plurality of melodies are divided based on phrase breaks and are stored, and a number of melodies which are similar to the user's request are detected from the stored melodies.