Patents by Inventor Jing-Hui Tian

Jing-Hui Tian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for treating respiratory disease
    Patent number: 12083228
    Abstract: Disclosed herein are methods and nanoparticles suitable for use in reducing exacerbations in COPD patients. The methods and compositions advantageously reduce the incidence of hospitalization in COPD patients that occurs in response to environmental insults such as exposure to or infection by RSV. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: September 10, 2024
    Inventors: Gale Smith, Ye Liu, Jing-Hui Tian, Michael J. Massare, Sarathi Boddapati, Gregory Glenn, Louis Fries, Iksung Cho
  • MULTIVALENT INFLUENZA NANOPARTICLE VACCINES
    Publication number: 20240293530
    Abstract: Disclosed herein are multivalent nanoparticle vaccine compositions suitable for use in influenza vaccines. The nanoparticles include effective amounts of influenza glycoproteins that provide increased immune responses compared to a commercially available influenza vaccine composition. The present disclosure also provides vaccine formulation strategies that are cost effective and are convenient for clinical use. Methods of administering the nanoparticle vaccine compositions to a subject are also disclosed.
    Type: Application
    Filed: January 3, 2024
    Publication date: September 5, 2024
    Inventors: Sarathi BODDAPATI, Anushree HERWADKAR, Jason WONG, Yen-Huei LIN, Gale SMITH, Jing-Hui TIAN
  • CORONAVIRUS VACCINE FORMULATIONS
    Publication number: 20240165221
    Abstract: Disclosed herein are coronavirus Spike (S) proteins and nanoparticles comprising the same, which are suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a detergent core resulting in enhanced stability and good immunogenicity. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.
    Type: Application
    Filed: December 1, 2023
    Publication date: May 23, 2024
    Inventors: Gale SMITH, Michael J. MASSARE, Jing-Hui TIAN
  • Methods and compositions for inducing immune responses against
    Patent number: 11938179
    Abstract: Disclosed herein are methods and compositions for treating or preventing bacterial infection. In particular, the methods and compositions are directed towards C. difficile infection. In particular aspects, the compositions are vaccines containing multimeric polypeptides containing portions of multiple toxins from bacteria. The polypeptides induce effective immune responses thus treating or preventing infection.
    Type: Grant
    Filed: August 10, 2021
    Date of Patent: March 26, 2024
    Assignee: Novavax, Inc.
    Inventors: Jing-Hui Tian, Ye Liu, Gale Smith, Gregory Glenn, David Flyer
  • Multivalent influenza nanoparticle vaccines
    Patent number: 11896662
    Abstract: Disclosed herein are multivalent nanoparticle vaccine compositions suitable for use in influenza vaccines. The nanoparticles include effective amounts of influenza glycoproteins that provide increased immune responses compared to a commercially available influenza vaccine composition. The present disclosure also provides vaccine formulation strategies that are cost effective and are convenient for clinical use. Methods of administering the nanoparticle vaccine compositions to a subject are also disclosed.
    Type: Grant
    Filed: November 24, 2021
    Date of Patent: February 13, 2024
    Assignee: Novavax, Inc.
    Inventors: Sarathi Boddapati, Anushree Herwadkar, Jason Wong, Yen-Huei Lin, Gale Smith, Jing-Hui Tian
  • Corona virus vaccine formulations
    Patent number: 11896664
    Abstract: Disclosed herein are coronavirus Spike (S) proteins and nanoparticles comprising the same, which are suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a detergent core resulting in enhanced stability and good immunogenicity. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.
    Type: Grant
    Filed: January 10, 2022
    Date of Patent: February 13, 2024
    Assignee: Novavax, Inc.
    Inventors: Gale Smith, Michael J. Massare, Jing-Hui Tian
  • CORONAVIRUS VACCINE FORMULATIONS
    Publication number: 20230330216
    Abstract: Disclosed herein are coronavirus Spike (S) proteins and nanoparticles comprising the same, which are suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a detergent core resulting in enhanced stability and good immunogenicity. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.
    Type: Application
    Filed: December 5, 2022
    Publication date: October 19, 2023
    Inventors: Gale SMITH, Michael J. MASSARE, Jing-Hui TIAN
  • ISOLATED POLYPEPTIDE OF THE TOXIN A AND TOXIN B PROTEINS OF C. DIFFICILE AND USES THEREOF
    Publication number: 20230173052
    Abstract: This present invention provides C-TAB.G5 and C-TAB.G5.1 isolated polypeptides comprising the receptor binding domains of C. difficile toxin A and toxin B as set forth in the amino acid sequences of SEQ ID NO: 2 and SEQ ID NO: 4. The C-TAB.G5 and C-TAB.G5.1 isolated polypeptides may be used to neutralize toxic effects of C. difficile toxin A and/or toxin B.
    Type: Application
    Filed: September 9, 2022
    Publication date: June 8, 2023
    Applicants: VALNEVA AUSTRIA GMBH, VALNEVA USA, INC.
    Inventors: Larry R. Ellingsworth, David Flyer, Jing-Hui Tian, Steven R. Fuhrmann, Stefanie Kluepfel-Stahl, Gregory M. Glenn, Kerstin Westritschnig
  • CORONAVIRUS VACCINE FORMULATIONS
    Publication number: 20230070886
    Abstract: Disclosed herein are coronavirus Spike (S) proteins and nanoparticles comprising the same, which are suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a detergent core resulting in enhanced stability and good immunogenicity. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.
    Type: Application
    Filed: January 27, 2021
    Publication date: March 9, 2023
    Inventors: Gale SMITH, Michael J. MASSARE, Jing-Hui TIAN
  • Coronavirus vaccine formulations
    Patent number: 11541112
    Abstract: Disclosed herein are coronavirus Spike (S) proteins and nanoparticles comprising the same, which are suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a detergent core resulting in enhanced stability and good immunogenicity. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.
    Type: Grant
    Filed: February 8, 2021
    Date of Patent: January 3, 2023
    Assignee: Novavax, Inc.
    Inventors: Gale Smith, Michael J. Massare, Jing-Hui Tian
  • VACCINE COMPOSITIONS HAVING IMPROVED STABILITY AND IMMUNOGENICITY
    Publication number: 20220387579
    Abstract: Disclosed herein are nanoparticles suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a detergent core resulting in enhanced stability and good immunogenicity. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.
    Type: Application
    Filed: May 23, 2022
    Publication date: December 8, 2022
    Inventors: Gale SMITH, Ye LIU, Jing-Hui TIAN, Michael J. MASSARE, Sarathi BODDAPATI, Erica SHANE, Cynthia OLIVER, Gregory GLENN
  • CORONAVIRUS AND INFLUENZA COMPOSITIONS AND METHODS FOR USING THEM
    Publication number: 20220354944
    Abstract: Disclosed herein are compositions and methods for inducing immune responses against both influenza and coronaviruses. Provided herein are compositions and methods of using the same, wherein the compositions comprise: (a) a coronavirus S (CoV S) glycoprotein in the form of a detergent-core nanoparticle, wherein the detergent is a non-ionic detergent; (b) at least three hemagglutinin (HA) glycoproteins, wherein each HA glycoprotein is from a different influenza strain; and (c) a pharmaceutically acceptable buffer.
    Type: Application
    Filed: May 4, 2022
    Publication date: November 10, 2022
    Inventors: Nita PATEL, Bin ZHOU, Mimi GUEBRE-XABIER, Jing-Hui TIAN, Alyse D. PORTNOFF, Michael J. MASSARE, Vivek SHINDE, Louis FRIES, Gale SMITH
  • Isolated polypeptide of the toxin A and toxin B proteins of and uses thereof
    Patent number: 11478540
    Abstract: This present invention provides C-TAB.G5 and C-TAB.G5.1 isolated polypeptides comprising the receptor binding domains of C. difficile toxin A and toxin B as set forth in the amino acid sequences of SEQ ID NO: 2 and SEQ ID NO: 4. The C-TAB.G5 and C-TAB.G5.1 isolated polypeptides may be used to neutralize toxic effects of C. difficile toxin A and/or toxin B.
    Type: Grant
    Filed: August 19, 2021
    Date of Patent: October 25, 2022
    Assignees: Valneva Austria GmbH, Valneva USA, Inc.
    Inventors: Larry R. Ellingsworth, David Flyer, Jing-Hui Tian, Steven R. Fuhrmann, Stefanie Kluepfel-Stahl, Gregory M. Glenn, Kerstin Westritschnig
  • CORONAVIRUS VACCINE FORMULATIONS
    Publication number: 20220332765
    Abstract: Disclosed herein are coronavirus Spike (S) proteins and nanoparticles comprising the same, which are suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a detergent core resulting in enhanced stability and good immunogenicity. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.
    Type: Application
    Filed: March 22, 2022
    Publication date: October 20, 2022
    Inventors: Gale SMITH, Michael J. MASSARE, Jing-Hui TIAN
  • METHODS AND COMPOSITIONS FOR INDUCING IMMUNE RESPONSES AGAINST CLOSTRIDIUM DIFFICILE
    Publication number: 20220211834
    Abstract: Disclosed herein are methods and compositions for treating or preventing bacterial infection. In particular, the methods and compositions are directed towards C. difficile infection. In particular aspects, the compositions are vaccines containing multimeric polypeptides containing portions of multiple toxins from bacteria. The polypeptides induce effective immune responses thus treating or preventing infection.
    Type: Application
    Filed: August 10, 2021
    Publication date: July 7, 2022
    Inventors: Jing-Hui TIAN, Ye LIU, Gale SMITH, Gregory GLENN, David FLYER
  • Vaccine compositions having improved stability and immunogenicity
    Patent number: 11364294
    Abstract: Disclosed herein are nanoparticles suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a detergent core resulting in enhanced stability and good immunogenicity. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: June 21, 2022
    Assignee: Novavax, Inc.
    Inventors: Gale Smith, Ye Liu, Jing-Hui Tian, Michael J. Massare, Sarathi Boddapati, Erica Shane, Cynthia Oliver, Gregory Glenn
  • Isolated polypeptide of the toxin A and toxin B proteins of and uses thereof
    Patent number: 11357844
    Abstract: This present invention provides C-TAB.G5 and C-TAB.G5.1 isolated polypeptides comprising the receptor binding domains of C. difficile toxin A and toxin B as set forth in the amino acid sequences of SEQ ID NO: 2 and SEQ ID NO: 4. The C-TAB.G5 and C-TAB.G5.1 isolated polypeptides may be used to neutralize toxic effects of C. difficile toxin A and/or toxin B.
    Type: Grant
    Filed: October 2, 2020
    Date of Patent: June 14, 2022
    Assignees: Valneva Austria GmbH, Valneva USA, Inc.
    Inventors: Larry R. Ellingsworth, David Flyer, Jing-Hui Tian, Steven R. Fuhrmann, Stefanie Kluepfel-Stahl, Gregory M. Glenn, Kerstin Westritschnig
  • CORONAVIRUS VACCINE FORMULATIONS
    Publication number: 20220125914
    Abstract: Disclosed herein are coronavirus Spike (S) proteins and nanoparticles comprising the same, which are suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a detergent core resulting in enhanced stability and good immunogenicity. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.
    Type: Application
    Filed: January 10, 2022
    Publication date: April 28, 2022
    Inventors: Gale SMITH, Michael J. MASSARE, Jing-Hui TIAN
  • Multivalent influenza nanoparticle vaccines
    Patent number: 11278612
    Abstract: Disclosed herein are multivalent nanoparticle vaccine compositions suitable for use in influenza vaccines. The nanoparticles include effective amounts of influenza glycoproteins that provide increased immune responses compared to a commercially available influenza vaccine composition. The present disclosure also provides vaccine formulation strategies that are cost effective and are convenient for clinical use. Methods of administering the nanoparticle vaccine compositions to a subject are also disclosed.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: March 22, 2022
    Assignee: Novavax, Inc.
    Inventors: Sarathi Boddapati, Anushree Herwadkar, Jason Wong, Yen-Huei Lin, Gale Smith, Jing-Hui Tian
  • MULTIVALENT INFLUENZA NANOPARTICLE VACCINES
    Publication number: 20220080039
    Abstract: Disclosed herein are multivalent nanoparticle vaccine compositions suitable for use in influenza vaccines. The nanoparticles include effective amounts of influenza glycoproteins that provide increased immune responses compared to a commercially available influenza vaccine composition. The present disclosure also provides vaccine formulation strategies that are cost effective and are convenient for clinical use. Methods of administering the nanoparticle vaccine compositions to a subject are also disclosed.
    Type: Application
    Filed: November 24, 2021
    Publication date: March 17, 2022
    Inventors: Sarathi BODDAPATI, Anushree HERWADKAR, Jason WONG, Yen-Huei LIN, Gale SMITH, Jing-Hui TIAN