Abstract: Provided is an oral Pt(IV) anticancer prodrug containing a 3-bromopyruvate as an axial ligand, with a molecular formula of cis,trans,cis-[Pt(1R,2R-diaminocyclohexane)(OH)(3-bromopyruvate)(C2O4)]. It is a prodrug of oxaliplatin and 3-bromopyruvic acid is a small molecular glycolysis inhibitor. The prodrug is able to simultaneously act on DNA replication and glycolytic pathways of cancer cells, giving full play to the advantage of double-acting targets. The oral Pt(IV) anticancer prodrug is synthesized by using oxaliplatin as a starting material, performing axial oxidation with H2O2 and neutralizing the oxidized product with 3-bromopyruvic acid.

Abstract: A method for synthesizing a labeled pyruvic acid is provided. An isopropenyl Grignard reagent is added to a reaction vessel and cooled to a preset temperature. A carbon isotope-labeled carbon dioxide is added to the reaction vessel and continuously reacted with the isopropenyl Grignard reagent for a preset time. The reaction system is added with an acid and adjusted to a preset temperature to quench the reaction. The reaction system is subjected to ozonization, and reduced in the presence of a reducing agent. Impurities are removed to obtain the labeled pyruvic acid.

Abstract: A miniature optoelectronic signal conversion and transmission device includes an optoelectronic signal module and an optical-fiber connector combined together. The optoelectronic signal module includes a silicon substrate that is electrically connected with a driver chip and an optoelectronic signal processor board arranged in a stacked package. The silicon substrate includes light-transmitting and light-receiving elements. Optical fibers provided in the optical-fiber connector have a signal receiving/transmitting terminal forming a refraction surface corresponding to and spaced from the light-transmitting and light-receiving elements. When an optical signal is transmitted through the optical fibers to the refraction surface, the optical signal is redirected for transmitting toward the light-transmitting and light-receiving elements.

Abstract: A continuous synthesis system of urea, including: a reactor, a mixing buffer tank for accommodating a first raw material, a feeding pump for pumping the first raw material to the reactor, a pressure regulating valve connected to the reactor to transfer a second raw material and regulate a pressure of the second raw material, a first heat exchanger connected to the reactor to regulate a temperature inside the reactor to a first preset temperature, and a back pressure valve connected to an end of the reactor away from the feeding pump to maintain a pressure of the continuous synthesis system at a preset pressure. The second raw material is gaseous. The second raw material is fed to the reactor through the pressure regulating valve to react with the first raw material in the reactor to generate a target product.

Abstract: A continuous-flow synthesis method of 13C-urea, including: (S1) mixing sulphur and a methanol solution containing NH3 in a feed kettle to obtain a slurry; or mixing ammonia gas, sulphur and methanol in a feed kettle to obtain a slurry; (S2) feeding the slurry into a mixing unit; and feeding 13CO into the mixing unit to obtain a three-phase mixture; (S3) mixing the three-phase mixture in the mixing unit evenly; feeding the three-phase mixture into a continuous-flow reactor for reaction to obtain a reaction product; and (S4) feeding the reaction product into a gas-liquid separator for gas-liquid separation, and collecting a liquid phase as a crude product solution; and subjecting the liquid phase to purification to obtain the 13C-urea.

Abstract: The photoelectric signal conversion and transmission device includes a photoelectric signal module and a fiber joint, matched and coupled together. A circuit board of the photoelectric signal module includes one or more connection bases. Light emission elements, light reception elements, and amplifiers are configured on a first coupling face of the connection based, and electrically connected by first and second wires. The fiber joint includes a number of fibers axially aligned with the light emission and reception elements. By having the light emission and reception elements and amplifiers configured on a same coupling face, their physical connection distance is reduced, thereby decreasing signal attenuation, enhancing signal transmission performance, and facilitating structural miniaturization.

Abstract: The photoelectric signal conversion and transmission device includes a photoelectric signal module and a fiber joint, matched and coupled together. A circuit board of the photoelectric signal module includes one or more connection bases. Light emission elements, light reception elements, and amplifiers are configured on a first coupling face of the connection based, and electrically connected by first and second wires. The fiber joint includes a number of fibers axially aligned with the light emission and reception elements. By having the light emission and reception elements and amplifiers configured on a same coupling face, their physical connection distance is reduced, thereby decreasing signal attenuation, enhancing signal transmission performance, and facilitating structural miniaturization.

Abstract: The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies.

Abstract: The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies.

Abstract: The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies.

Abstract: Compositions and methods for enhancing an immune response and treating cancer are provided. Compositions comprise PD-1 axis antagonists and HPK1 antagonists. PD-1 axis antagonists include PD-1 antagonists, PD-L1 antagonists, and PD-L2 antagonists. PD-1 axis antagonists can inhibit the binding of PD-L1 and/or PD-L2 to PD-1. HPK1 antagonists include compounds that inhibit the serine/threonine kinase activity of HPK1. Methods for enhancing an immune response or treating cancer comprise administering a PD-1 axis antagonist and a HPK1 antagonist, sequentially or simultaneously, to a subject in need thereof.

Abstract: The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies.

Abstract: The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies.

Abstract: The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies.

Abstract: The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies.

Abstract: The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies.

Abstract: Compositions and methods for enhancing an immune response and treating cancer are provided. Compositions comprise PD-1 axis antagonists and HPK1 antagonists. PD-1 axis antagonists include PD-1 antagonists, PD-L1 antagonists, and PD-L2 antagonists. PD-1 axis antagonists can inhibit the binding of PD-L1 and/or PD-L2 to PD-1. HPK1 antagonists include compounds that inhibit the serine/threonine kinase activity of HPK1. Methods for enhancing an immune response or treating cancer comprise administering a PD-1 axis antagonist and a HPK1 antagonist, sequentially or simultaneously, to a subject in need thereof.

Abstract: Provided herein are therapies for the treatment of pathological conditions, such as cancer, and method of using SCD1 antagonists.

Abstract: A system and method for enabling content to be displayable in association with a local client printing system associated with a printer provider. The local client printing system, in response to commands entered through the user interface, communicates with a remote printer provider server to retrieve displayable content associated with the commands entered through a user interface. The local client printing system, in response to commands entered through the user interface, communicates with the remote printer provider server to identify the display device upon which the retrieved displayable content is to be displayed. The display device receives, from the remote printer provider server, the retrieved displayable content and displays the retrieved displayable content thereupon.

Abstract: A system and method for providing printing services to a mobile device connected to a network provides a remote print service provider server and local printers. The mobile device transmits a printer location request to the remote print service provider server. The remote print service provider server determines a physical location of the mobile device; determines which local printers are located within a predetermined parameter of the physical location of the mobile device; and transmits information to the mobile device identifying physical locations of local printers with respect to the physical location of the mobile device. The mobile device selects a local printer identified by the remote print service provider server and transmits, to the remote print service provider server, a print request. The remote print service provider server transmits the print request to the selected local printer.