Abstract: A feedback control system configured to drive a load is disclosed. The feedback control system includes an up-sampling circuit, configured to perform an un-sampling operation on a source signal and produce an up-sampled signal with an up-sampling frequency according to the up-sampled signal and a feedback signal from the load; a delta circuit, coupled to the up-sampling circuit and configured to produce a delta signal; a sigma circuit, configured to produce a density modulation signal according to the delta signal; and a driving device, configured to drive the load according to the density modulation signal with the up-sampling frequency.

Abstract: The present disclosure provides a cytokine-based bioactivatable drug construct (“VitoKine”) platform that aims to reduce systemic mechanism-based toxicities and lead to broader therapeutic utility for proteins and cytokines such as IL-15 and IL-2 for the treatment of cancer, autoimmune diseases, inflammatory diseases, viral infection, transplantation and various other disorders. The novel VitoKine constructs of the present invention comprise: 1) a tissue or disease site targeting moiety D1 domain (“D1”), 2) a bioactivatable moiety D2 domain (“D2”), and a concealing moiety D3 domain (“D3”). Importantly, because the “active moiety” of the VitoKine construct will remain inert until activated locally by proteases that are upregulated in diseased tissues, this will limit binding of the active moiety to the receptors or to the targets in the peripheral or on the cell-surface of non-diseased cells and tissue to prevent over-activation of the pathway and reduce undesirable “on-target” “off tissue” toxicities.

Abstract: A system and method for real-time transmission of a panoramic video, which propose a new grouping method and bitrate decision method specifically for a panoramic 360-degree video. The grouping method takes into account fields of view of different users, thus effectively reducing the bandwidth consumption of repeated video segments, while ensuring user fairness and making full use of network bandwidth resources when allocating resources. The system and method of the invention can maximize the long-term QoE of users under the condition of limited bandwidth, and avoid the problem that the existing schemes are complex and difficult to meet real-time requirements of users.

Abstract: The present invention discloses a high step-down modular DC power supply, belonging to the field of power electronics technology, and the high step-down modular DC power supply includes an upper modular cascade circuit string, a lower modular cascade circuit string, a load, and an input source, where the upper modular cascade circuit string includes i upper sub-module circuits, and the lower modular cascade circuit string includes j lower sub-module circuits. A combination manner of module circuits includes: upper module string cascading, lower module string cascading, and hybrid cascading of the upper module string and the lower module string. The power supply is formed to be a high voltage step-down ratio power supply with high voltage direct current input and low voltage direct current output through modular cascading.

Abstract: A method including the step contacting an olefin, an alcohol, a metallosilicate catalyst and a solvent, wherein the solvent comprises structure (I): wherein R1 and R2 are each selected from the group consisting of an aryl group and an alkyl group with the proviso that at least one of R1 and R2 is an aryl group, further wherein n is 1-3.

Abstract: The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.

Abstract: A chip package and method for fabricating the same are provided that includes embedded off-die inductors coupled in series. One of the off-die inductors is disposed in a redistribution layer formed on a bottom surface of an integrated circuit (IC) die. The other of the series connected off-die inductors is disposed in a substrate of the chip package. The substrate may be either an interposer or a package substrate.

Abstract: Insoles and methods for making shoe insoles are disclosed An insole model can be generated based on a profile of a foot and a patient-specific pressure distribution. The profile of the foot can comprise a scan of a crush box impression. An insole can be formed from the insole model.

Abstract: The present invention discloses a high step-down modular DC power supply, belonging to the field of power electronics technology, and the high step-down modular DC power supply includes an upper modular cascade circuit string, a lower modular cascade circuit string, a load, and an input source, where the upper modular cascade circuit string includes i upper sub-module circuits, and the lower modular cascade circuit string includes j lower sub-module circuits. A combination manner of module circuits includes: upper module string cascading, lower module string cascading, and hybrid cascading of the upper module string and the lower module string. The power supply is formed to be a high voltage step-down ratio power supply with high voltage direct current input and low voltage direct current output through modular cascading.

Abstract: A battery-operated device including a rechargeable battery and an interchangeable drive unit that is supplied with power by the rechargeable battery via an electromechanical interface is provided. The rechargeable battery is chargeable via the electromechanical interface.

Abstract: The invention generates synthetic composite waveforms for determining an individual's physiological state, and includes steps of: obtaining a periodic physiological signal of an individual within a time frame; analyzing the periodic physiological signal to obtain and to convert peak-to-peak time intervals of the periodic physiological signal into frequencies; establishing a physiological variation waveform according to the variation of the frequencies; defining at least one synthetic basic waveform according to the frequency trend or fluctuation amplitude of the physiological variation waveform; combining at least two synthetic basic waveforms to generate at least one synthetic composite waveform; and defining respectively each of the at least one synthetic composite waveform as a physiological state.

Abstract: An ESD protection structure includes a first conductive type substrate; first and second well regions of a first conductive type; a third well region of a second conductive type located between the first and second well regions; a first doped region of the first conductive type and a second doped region of the second conductive type disposed in the first well region; a third doped region of the first conductive type and a fourth doped region of the second conductive type disposed in the second well region; and fifth and sixth doped regions disposed at an interface of the first and third well regions or an interface of the second and third well regions. The fifth doped region of the first conductive type is located in the first or second well region, and the sixth doped region of the second conductive type is located in the third well region.

Abstract: The present invention provides a method for patent valuation, comprising steps of providing a patent group for establishing a citation network and selecting a cluster within the citation network, wherein the citation network comprises a plurality of links, each link is formed between any two patent cases having citation relationship with each other; afterwards, designating weighting value for each link connecting each pair of patent cases; finally, calculating a plurality of centrality indices with respect to the plurality of patent cases in the cluster respectively according to the weighting value of each link. By means of the method of the present invention, it is capable of obtaining a relative value or significance of a specific patent case with respect to the other patent cases within the cluster.

Abstract: A method for fabricating an array pH sensor and a readout circuit device of such array pH sensor are implemented by utilizing an extended ion sensitive field effect transistor to construct the array pH sensor and related readout circuit. The structure of the array sensor having this extended ion sensitive field effect transistor comprises a tin dioxide/metal/silicon dioxide multi-layer structure sensor and a tin dioxide/indium tin oxide/glass multi-layer structure sensor and has excellent properties. Furthermore, the readout circuit and the sensor utilize two signal generators for controlling and reading signals. In particular, the sensor can be effective for increasing the accuracy of measurement and reducing the interference of noise.

Abstract: A method for fabricating an array pH sensor and a readout circuit device of such array pH sensor are implemented by utilizing an extended ion sensitive field effect transistor to construct the array pH sensor and related readout circuit. The structure of the array sensor having this extended ion sensitive field effect transistor comprises a tin dioxide/metal/silicon dioxide multi-layer structure sensor and a tin dioxide/indium tin oxide/glass multi-layer structure sensor and has excellent properties. Furthermore, the readout circuit and the sensor utilize two signal generators for controlling and reading signals. In particular, the sensor can be effective for increasing the accuracy of measurement and reducing the interference of noise.

Abstract: A method for fabricating an array pH sensor and a readout circuit device of such array pH sensor are implemented by utilizing an extended ion sensitive field effect transistor to construct the array pH sensor and related readout circuit. The structure of the array sensor having this extended ion sensitive field effect transistor comprises a tin dioxide/metal/silicon dioxide multi-layer structure sensor and a tin dioxide/indium tin oxide/glass multi-layer structure sensor and has excellent properties. Furthermore, the readout circuit and the sensor utilize two signal generators for controlling and reading signals. In particular, the sensor can be effective for increasing the accuracy of measurement and reducing the interference of noise.

Abstract: The present invention discloses a stopper composed of a hyaline port, a coupling, a light emitting means, a buffer ring, an embedding port and an insertion. The light emitting means is positioned in a top hollow of the coupling and then embedded into a cave of the hyaline port. An insulated ring surrounding batteries is housed in the lower hollow of the coupling. The coupling can be eventually screwed in the embedding port deposited in the insertion. By screwing the coupling more tightly, a lead beneath the light emitting means can contact with the battery to form electrical conduction, and therefore the hyaline port exhibits fancy or identification effect.

Abstract: The present invention discloses a stopper composed of a hyaline port, a coupling, a light emitting means, a buffer ring, an embedding port and an insertion. The light emitting means is positioned in a top hollow of the coupling and then embedded into a cave of the hyaline port. An insulated ring surrounding batteries is housed in the lower hollow of the coupling. The coupling can be eventually screwed in the embedding port deposited in the insertion. By screwing the coupling more tightly, a lead beneath the light emitting means can contact with the battery to form electrical conduction, and therefore the hyaline port exhibits fancy or identification effect.

Abstract: A handle for a suitcase includes a base having two barrels disposed in the end portions for slidably receiving two tubes. A plate is secured to the bottom of the base and two slides are slidably engaged in the plate. The slides each has a latch for engaging with the tubes and each includes an inclined slot. A knob includes two inclined legs engaged with the inclined slots of the slides. The slides are moved toward each other or moved away from each other by the engagement of the inclined legs of the knob with the inclined slots of the slides.

Abstract: A rotatable handle assembly includes a housing having a pair of casings for rotatably receiving a pair of barrels. A pair of tubes are slidably engaged in the housing and slidably engaged in the barrels such that the tubes are rotated in concert with the barrels. The tube and the barrel may rotate relative to the casing when the lower end of the tube is disengaged from the casing and is received in the barrel. The casings each includes a projection for engaging with one or more cavities of the barrel so as to position the barrel at an angular position relative to the casing.