Abstract: Formulations of the HIV compounds atazanavir and cobicistat, and methods of treatment utilizing these formulations, are set forth.

Abstract: A viable strategy to enhance the bioavailability of poorly soluble drugs is to use amorphous solids in place of the more commonly used crystalline solids in pharmaceutical formulations. However, amorphous solids are physically meta-stable and tend to revert back to their crystalline counterpart. An effective approach to stabilizing an amorphous drug against crystallization is to disperse it in a polymer matrix. The drug's solubility in the chosen polymer defines the upper limit of drug loading without any risk of crystallization. Measuring the solubility of a drug in a polymer has been a scientific and technological challenge because the high viscosity of polymers makes achieving solubility equilibrium difficult and because pharmaceutically important drug/polymer dispersions are glasses, which undergo structural relaxation over time. The invention provides a method based on Differential Scanning calorimetry (DSC) for measuring the solubility of crystalline drugs in polymeric matrices.

Abstract: The present disclosure discloses a converter system, which at least includes the first and second back-to-back converters. The first back-to-back converter includes a first rectifier module and a first inverter module. The first rectifier module is used to convert a first AC voltage to a first DC voltage. The first inverter module is used to convert the first DC voltage to a second AC voltage. The second back-to-back converter includes a second rectifier module and a second inverter module. The second rectifier module is used to convert the first AC voltage to a second DC voltage. The second inverter module is used to convert the second DC voltage to the second AC voltage. The converter system can suppress the circular current through the synchronous operation of the first and second rectifiers or the synchronous operation of the first and second inverters.

Abstract: Embodiments of the present disclosure provide for polymer nanocomposites, methods of making polymer nanocomposites, and the like.

Abstract: A power circuit, a converter structure and a wind power generation system thereof are disclosed. The power circuit includes a first converter having an AC input side and a DC output side, a second converter having a DC input side and an AC output side, and a DC bus storage unit electrically connected to the DC output side of the first converter and the DC input side of the second converter. A level number, a switching valve type and/or a circuit connection of the first converter are different from those of the second converter.

Abstract: The present disclosure discloses a converter system, which at least includes the first and second back-to-back converters. The first back-to-back converter includes a first rectifier module and a first inverter module. The first rectifier module is used to convert a first AC voltage to a first DC voltage. The first inverter module is used to convert the first DC voltage to a second AC voltage. The second back-to-back converter includes a second rectifier module and a second inverter module. The second rectifier module is used to convert the first AC voltage to a second DC voltage. The second inverter module is used to convert the second DC voltage to the second AC voltage. The converter system can suppress the circular current through the synchronous operation of the first and second rectifiers or the synchronous operation of the first and second inverters.

Abstract: A method for evaluating the solubility of a crystalline substance in a polymer comprises a) providing at least one sample of an intimate crystalline substance/polymer mixture at a predetermined crystalline substance concentration; b) annealing the sample at a constant temperature Ta for a period of time; c) heating the annealed sample while recording the heat flux over time by DSC; d) identifying a DSC dissolution endotherm in the recorded heat flux, if any; e) considering the crystalline substance concentration as a concentration above the crystalline substance solubility in the polymer at temperature Ta when there is a DSC dissolution endotherm identified, and considering the crystalline substance concentration as a concentration less than or equal to the crystalline substance solubility in the polymer at temperature Ta when there is no DSC dissolution endotherm identified.

Abstract: The present invention relates to a method of treating a gastrointestinal disorder by administering to a patient in need of treatment thereof a pharmaceutical composition, wherein said pharmaceutical composition can be administered to the patient independent of the intake of food.

Abstract: A method of controlling an uninterruptible power supply apparatus (UPS) is provided. The UPS apparatus includes at least an AC input voltage, a DC input voltage and a single-phase AC/AC converter. The single-phase AC/AC converter includes an AC inductor, a bus capacitor, a boost arm, a common arm and a buck arm. The method includes steps of: controlling the bus voltage to have a DC component and full-wave rectifying component, and setting a bus voltage parameter K so that the bus voltage approaches to a full-wave rectifying voltage when K approaches to 1, wherein 0?K?1.

Abstract: A viable strategy to enhance the bioavailability of poorly soluble drugs is to use amorphous solids in place of the more commonly used crystalline solids in pharmaceutical formulations. However, amorphous solids are physically meta-stable and tend to revert back to their crystalline counterpart. An effective approach to stabilizing an amorphous drug against crystallization is to disperse it in a polymer matrix. The drug's solubility in the chosen polymer defines the upper limit of drug loading without any risk of crystallization. Measuring the solubility of a drug in a polymer has been a scientific and technological challenge because the high viscosity of polymers makes achieving solubility equilibrium difficult and because pharmaceutically important drug/polymer dispersions are glasses, which undergo structural relaxation over time. The invention provides a method based on Differential Scanning calorimetry (DSC) for measuring the solubility of crystalline drugs in polymeric matrices.

Abstract: An uninterruptible power supply module is provided. The uninterruptible power supply module comprises an input terminal, a direct-current voltage source, a control module, a control arm-bridge module, an inductive element, a power source selection switch, and a switch element. The switch element is turned on before the power source selection switch is connected to the inductive element so that the direct-current voltage supplied by the direct-current voltage source is modulated by the control arm-bridge module to generate an output alternating current voltage to the load. And the switch element is turned off, i.e. not conducting electricity, after the power source selection switch is connected to the inductive element and the direct-current voltage source. Thereby, the use life of the power source selection switch element and the reliability of the uninterruptible power supply module are both increased.

Abstract: A method of controlling an uninterruptible power supply apparatus (UPS) is provided. The UPS apparatus includes at least an AC input voltage, a DC input voltage and a single-phase AC/AC converter. The single-phase AC/AC converter includes an AC inductor, a bus capacitor, a boost arm, a common arm and a buck arm. The method includes steps of: controlling the bus voltage to have a DC component and full-wave rectifying component, and setting a bus voltage parameter K so that the bus voltage approaches to a full-wave rectifying voltage when K approaches to 1, wherein 0?K?1.

Abstract: A power converter and a power converting method are provided. The power converter for converting an ac input voltage at an input terminal thereof into an ac output voltage at an output terminal thereof includes an energy-storing inductor, a first switching circuit coupled to the energy-storing inductor to selectively switch so that the input terminal of the power converter is coupled to the energy-storing inductor, a second switching circuit coupled to the energy-storing inductor and the first switching circuit to selectively switch so that a common terminal of the power converter is coupled to the energy-storing inductor; and a third switching circuit coupled to the energy-storing inductor, the first switching circuit and the second switching circuit to selectively switch so that the output terminal of the power converter is coupled to the energy-storing inductor.

Abstract: The present invention provides a three-level ac generating circuit and the control method thereof. The three-level ac generating circuit includes a three-level boosting circuit connected to an input source and including a positive boosting portion and a negative boosting portion; and a three-level inverting circuit connected to the three-level boosting circuit and including a positive inverting portion and a negative inverting portion, wherein while the input source is a relative low voltage, the relatively low voltage is boosted via the three-level boosting circuit, inverted and output via the three-level inverting circuit; while the input source is a relatively high voltage, the relatively high voltage is inverted and output via the three-level inverting circuit and wherein the output of the three-level ac generating circuit is power grid.

Abstract: A method and apparatus for determining the parameters for disc recording is provided. For those discs that haven't pre-stored recording information or have pre-stored recording information not meeting the quality requirement, according to the method of the present invention, set the initial values of record strategy parameters firstly, then perform disc recording test with a group of parameters that have close relevancy among each other according to the method designed in the experiment, and finally determine the relationship between each optimal parameters and the optical disc recording quality, so that optimal parameters value corresponding to each parameter can be obtained for disc recording. According to the present invention, the optimal disc recording parameters can be determined within the limited time and limited space of disc recording test.

Abstract: An uninterruptible power supply module is provided. The uninterruptible power supply module comprises an input terminal, a direct-current voltage source, a control module, a control arm-bridge module, an inductive element, a power source selection switch, and a switch element. The switch element is turned on before the power source selection switch is connected to the inductive element so that the direct-current voltage supplied by the direct-current voltage source is modulated by the control arm-bridge module to generate an output alternating current voltage to the load. And the switch element is turned off, i.e. not conducting electricity, after the power source selection switch is connected to the inductive element and the direct-current voltage source. Thereby, the use life of the power source selection switch element and the reliability of the uninterruptible power supply module are both increased.

Abstract: The present invention relates to a method of treating a gastrointestinal disorder by administering to a patient in need of treatment thereof a pharmaceutical composition, wherein said pharmaceutical composition can be administered to the patient independent of the intake of food.

Abstract: A converting device with PFC and dc/dc converting functions is provided. The converting device includes a power source providing a dc voltage, an inverter having an input terminal electrically connected to the power source and an output terminal, a transformer having a primary winding electrically connected to the output terminal of the inverter and a secondary winding, a rectifier/filter circuit having an input terminal electrically connected to the secondary winding of the transformer and an output terminal, and a PFC converter coupled to the output terminal of the rectifier/filter circuit and having an input terminal receiving an ac input voltage. The converting device converts the ac input voltage into an ac output voltage when the ac input voltage is normal, and converts the dc voltage to output the ac output voltage with the cooperation of the inverter, the transformer, the rectifier/filter circuit and the PFC converter when the ac input voltage is abnormal.

Abstract: An integrated converter having three-phase power factor correction is provided. The integrated converter includes two PFC circuits. Two DC/DC converters are controlled and switched by the integrated converter in accordance with a three-phase AC power source so as to convert the AC power source into a DC power source. The use of the elements in the integrated converter is efficient.

Abstract: The present invention provides a method and apparatus for optimizing optical disc writing strategy. The method for optimizing optical disc writing strategy comprises the steps of obtaining the information concerning whether said area to be written has experienced any writing before; searching for an area that has the corresponding information in the writing optimization area on said optical disc; and performing writing test on said area that has the corresponding information to optimize and determine an optical disc writing strategy for writing said optical disc. The method and apparatus could not only reduce the difference between the optical disc writing strategy and the real optical disc writing condition as much as possible, but also lower the requirement on the optical disc writing equipment and the cost, and could be easily realized.