Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that bind to human CCR8, a pharmaceutical composition comprising said antibody, and use of the antibody or the composition for treating a disease, such as cancer.

Abstract: The present invention provides silver pastes used for manufacturing a printed antenna, kit-of-parts for preparing a printed antenna for an electronic device comprising three kinds of the silver pastes, use of the silver paste as a via fill ink, a method for preparing a printed antenna circuit with the three kinds of the silver pastes, a printed antenna for an electronic device obtained with the silver pastes, and an electronic device comprising the printed antenna.

Abstract: A terminal according to one aspect of the present disclosure includes a receiving section that receives downlink control information including a resource assignment of a physical uplink shared channel and a value of an antenna port indication, and a control section that controls transmission of a demodulation reference signal (DMRS), based on an association between the value, the number of code division multiplexing (CDM) groups, and a DMRS port. The number of the CDM groups for DMRS configuration type 1 is larger than 2, and the number of the CDM groups for DMRS configuration type 2 is larger than 3. According to one aspect of the present disclosure, an appropriate number of DMRS ports can be used.

Abstract: A machine learning power consumption model and process are provided for determining power consumption of computing environment resources in handling requests of an application. The process includes training the machine learning power consumption model to estimate power consumption of computing environment resources in handling requests. The training uses a training dataset derived from historical request-related data, and the training dataset includes request-related data and resource power consumption data. In addition, the process includes analyzing the requests. The analyzing includes, for a particular request of the requests, obtaining a common pattern of resource use and collecting real-time trace metrics to facilitate allocating resource use to the particular request.

Abstract: Bifunctional compounds, which find utility as modulators of leucine-rich repeat kinase 2 (LRRK2), are described herein. In particular, the hetero-bifunctional compounds of the present disclosure contain on one end a moiety that binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds LRRK2, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The hetero-bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aberrant regulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

Abstract: Aspects of the present disclosure provide techniques for configuring a search space for sidelink communications between one or more sensors/actuators (SAs) and programmable logic controller (PLC) in internet of things (IoT) applications in order to minimize the number of subchannels that a receiver (e.g., PLC or SA) may need to blind decode. More particularly, the search space is configurable based on a hashing function that is based in part on a portion of the resources (e.g., PLC resources) that have been allocated or reserved for sidelink communication within the PLC subnetwork (or PLC group) from the sidelink resource pool available to a plurality of PLCs in a network. By limiting the search space to a subset of resources that are specific to the PLC subnetwork or group, the need for the SA or PLC to perform blind decoding of sidelink control information (SCI) may be further reduced.

Abstract: Provided is a polypeptide combination, a targeting component thereof comprising a shielding peptide, a cleavable part, an antigen-binding part and a first intein fragment, the shielding peptide and the antigen-binding part being connected by means of the cleavable part, and the antigen-binding part being directly or indirectly connected to the first intein fragment; a toxin component thereof comprises a second intein fragment and a toxin, and the second intein fragment is directly or indirectly connected to the toxin; the targeting component and the toxin component form an immunoconjugate by means of the interactive action between the first intein fragment and the second intein fragment; in the immunoconjugate, the shielding peptide and the antigen-binding part are connected by means of the cleavable part, and the antigen-binding part is connected to the toxin. Also provided are a preparation method and a pharmaceutical use for the polypeptide combination.

Abstract: The present disclosure provides a high-entropy rare earth-toughened tantalate ceramic. The ceramic is prepared by sintering Ta2O5 powder and x types of different RE2O3 powder, 4?x?9, and the molar ratio of the RE2O3 powders is 1. RE2O3 powder and Ta2O5 powder having the molar ratio of RE to Ta being 1:1 are weighed, a solvent is added for mixing, and ball milling is performed by a ball mill to obtain mixed powder M; the powder M is dried at a temperature of 650-850° C. for 1.5-2 h to obtain dried powder; the powder is sieved to obtain powder N, the powder N is placed in a mold for first pressing to obtain a rough blank, and the rough blank is then pressed for the second time to obtain a compact blank; the compact blank is sintered to obtain the high-entropy rare earth-toughened tantalate ceramic.

Abstract: A dimming module and method for manufacturing the same, and a dimming glass, relate to the field of smart glass technology. The dimming module includes: a first dimming structure (10) and a second dimming structure (20). Each of the first dimming structure (10) and the second dimming structure (20) includes a first substrate (1), a second substrate (2) and a liquid crystal layer (3), and a first flexible circuit board (4) and a second flexible circuit board (5). The first substrate (1) is provided with a first binding area (11), and a first electrode (6) on one side facing the liquid crystal layer (3). The second substrate (2) is provided with a second binding area (21), and a plurality of second electrodes (7) on one side facing the liquid crystal layer (3).

Abstract: Disclosed are a tricyclic compound, and a preparation method therefor and the use thereof. The tricyclic compound has a structure as shown in formula I, and can be used for treating various mental diseases and neurodegenerative diseases such as schizophrenia, depression and Parkinson's disease.

Abstract: This disclosure is directed to a pharmaceutical composition for treating or preventing a disease. The pharmaceutical composition can comprise a polymer-drug nanoaggregate having a polymer and at least one bioactive agent that can comprise STING polypeptide, a nucleic acid encoding said STING polypeptide, a STING inhibitor, a STING activator, a STING agonist, a STING antagonist, a STING modulating molecule, or a combination thereof. The pharmaceutical composition can be a vaccine or an adjuvant for a vaccine. This disclosure is also directed to a method for treating or preventing a disease using the pharmaceutical composition. The disease can include infectious diseases caused by viruses or other pathogens, for example, influenza, rabies, or respiratory illnesses such as severe acute respiratory syndrome (SARS) caused by coronaviruses, such as MERS-CoV, SARS-CoV, and Coronavirus Disease 2019 (COVID-19) caused by the virus SARS-CoV-2 and its variants.

Abstract: A method includes obtaining, using at least one under display camera, one or more first image frames associated with a first diffraction pattern and one or more second image frames associated with a second diffraction pattern. The first diffraction pattern and the second diffraction pattern are related through a transformation. The method also includes generating a first deblurred image using the one or more first image frames and a second deblurred image using the one or more second image frames. The method further includes combining the first and second deblurred images while exploiting complementary types of image artifacts created by the first and second diffraction patterns to generate an image of a scene.

Abstract: A data processor that is operable to be coupled to a memory includes a memory operation array, a controller, a refresh logic circuit, and a selector. The memory operation array is for storing memory operations for a first power state of the memory. The controller is responsive to a power state change request to execute a plurality of memory operations from the memory operation array when the first power state is selected. The refresh logic circuit generates refresh cycles periodically for the memory. The selector is for multiplexing the refresh cycles with the memory operations during a power state change to the first power state.

Abstract: The present disclosure relates to systems, non-transitory computer-readable media, and methods for providing a secure development environment for developing computer models by utilizing an exploration environment in conjunction with a production environment. In particular, the disclosed systems provide a method for a client account to develop machine learning models securely and efficiently (e.g., access, generate, train, and activate) by utilizing a scalable exploration environment isolated from a production environment. Further, the disclosed systems can provide a system for the client account to utilize to convert the exploration model to a production model and activate the production model within the production environment. In this way, the disclosed systems provide a separation between the exploration environment and the production environment when testing models and thus constrain the impact of testing models to the production environment.

Abstract: Embodiments of the present application relate to methods and apparatuses of a link management and mobility for an uplink (UL) aggregation procedure. According to an embodiment of the present application; a user equipment (UE) includes a processor and a transceiver coupled to the processor; and the processor is configured: to access a serving cell of a network node via a direct path; to transmit, via the transceiver, information indicating whether the UE supports an uplink (UL) aggregation to the network node; and to receive, via the transceiver, a radio resource control (RRC) reconfiguration message from the network node, wherein the RRC reconfiguration message includes an indication to indicate the UE to establish an indirect path for UL aggregation. After establishing the multiple path for UL aggregation, the UE receives a radio resource control (RRC) reconfiguration message for handover.

Abstract: The present application discloses a carrier wave distortion compensation method for an MWD mud continuous wave system, comprising: in the downhole, modulating the carrier wave according to the transmission data to obtain a mud continuous wave signal to be transmitted; transmitting the mud continuous wave signal to the ground via a mud channel; denoising the received pressure signal on the ground to obtain a denoised mud continuous wave signal; performing subsequent processing on the denoised mud continuous wave signal to obtain the final transmission data; and performing downhole distortion compensation before modulating the carrier wave or performing ground distortion compensation on the denoised mud continuous wave signal before performing subsequent processing. The present application reduces the bit error rate of the MWD mud continuous wave system by performing waveform distortion compensation prior to downhole modulation or during performing signal processing on the ground.

Abstract: The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of targeted polypeptides.

Abstract: A method including detecting, in a written electronic communication, an input sentence satisfying a readability metric threshold. The method also includes transforming, by a sentence transformer model, the input sentence to output suggested sentences. The method also includes evaluating the suggested sentences along a set of acceptability criteria. The method also includes determining, based on the evaluating, that the set of acceptability criteria is satisfied. The method also includes modifying, based on determining that the set of acceptability criteria is satisfied, the written electronic communication with the suggested sentences to obtain a modified written electronic communication. The method also includes returning the modified written electronic communication.

Abstract: A process for producing lower olefins from oxygenates includes the steps of contacting a feedstock comprising oxygenates with molecular sieve catalyst in fluidized bed reaction zone under effective conditions, to produce product including ethylene and/or propylene; the effective conditions include that in the fluidized bed reaction zone, the weights of catalysts having various carbon deposition amounts are controlled, calculated as the weight of the molecular sieve in the catalysts, to have the following proportions based on the total weight of the catalysts in the fluidized bed reaction zone: the proportion of the weight of the catalyst having a coke deposition amount of less than 3 wt % is 1-20 wt %; the catalyst having a coke deposition amount of from 3 wt % to less than 5 wt % represents 10 to 70 wt %; and the catalyst having a coke deposition amount from 5 wt % to 10 wt % represents 10 to 88 wt %.