Publication number: 20250122224
Abstract: Disclosed herein are salt and solvate forms of (4S,7aR,9aR,10R,11E,14S,15R)-6?-chloro-10-methoxy-14,15-dimethyl-10-{[(9aR)-octahydro-2H-pyrido[1,2-a]pyrazin-2-yl]methyl}-3?,4?,7a,8,9,9a,10,13,14,15-decahydro-2?H,3H,5H-spiro[1,19-etheno-16,16-cyclobuta[i][1,4]oxazepino[3,4-f][1,2,7]thiadlazacyclohexadecine-4,1 naphthalene]-16,16,18 (7H,17H)-trione (AMG 397): (AMG 397), such as crystalline salt and solvate forms thereof. Also disclosed are methods of making the salt and solvate forms, and methods of treating diseases and disorders with the salt and solvate forms.
Type:
Application
Filed:
February 3, 2023
Publication date:
April 17, 2025
Inventors:
Ron C. Kelly, Mary Chaves, Jing Teng, Stephan Parent, Van Luu, Robert P. Farrell, James E. Huckle, Michal Achmatowicz, Tian Wu, Darren Leonard Reid, Lingyun Xiao