Abstract: The present invention relates to use of homoharringtonine in manufacturing a drug for treating an acquired immunodeficiency syndrome. A homoharringtonine compound is prepared as a drug for treating the acquired immunodeficiency syndrome and is applied to the treatment of the acquired immunodeficiency syndrome. The homoharringtonine compound can significantly reduce the programmed ribosomal frameshifting (PRF) efficiency of the mRNA of HIV-1 during the translation of a Gag-Pol fusion protein to substantially decrease the translation efficiency of the Pol protein. Therefore, the cell fails to produce protease, integrase, and reverse transcriptase obtained via Pol splicing such that a virus cannot be packaged effectively, which eventually leads to a sharp decline in yield of the virus. Therefore, the compound of the present invention has a good anti-HIV effect.

Abstract: The present disclosure relates to an imaging system and method. Specifically, an imaging system comprises: a positioning image acquisition unit, configured to acquire a positioning image of a scanning object; a monitoring slice image acquisition unit, configured to determine a key point corresponding to the position of a target region of interest in the positioning image by using a neural network, and acquire a monitoring slice image of the scanning object at the position of the key point; and a target region-of-interest segmentation unit, configured to segment the monitoring slice image to obtain the target region of interest. The present disclosure can accurately acquire the position of the monitoring slice, and can accurately obtain the target region of interest through segmentation by a cascaded coarse segmentation and fine segmentation.

Abstract: A method of processing an optical device is provided, including: positioning an optical device on a substrate support in an interior volume of a process chamber, the optical device including an optical device substrate and a plurality of optical device structures formed over the optical device substrate, each optical device structure including a bulk region formed of silicon carbide and one or more surface regions formed of silicon oxycarbide. The method further includes providing one or more process gases to the interior volume of the process chamber, and generating a plasma of the one or more process gases in the interior volume for a first time period when the optical device is on the substrate support, and stopping the plasma after the first time period. A carbon content of the one or more surface regions of each optical device structure is reduced by at least 50% by the plasma.

Abstract: A recombinant multivalent vaccine including a recombinant protein is provided. The recombinant protein includes, from a N-terminus to a C-terminus, a first antigenic peptide, an N-polypeptide (SEQ ID NO: 1), a second antigenic peptide, a C-polypeptide (SEQ ID NO: 3) and a third antigenic peptide, where the N-polypeptide and the C-polypeptide are intramolecular scaffold-forming polypeptides, forming an intramolecular scaffold NC for supporting and stabilizing conformations of the first antigenic peptide, the second antigenic peptide and the third antigenic peptide. The recombinant multivalent vaccines 3Ro-NC (SEQ ID NO: 17) and 3Rs-NC (SEQ ID NO: 19) are provided to against SARS-COV-2 variants. The 3Ro-NC plus KFD is used as a prophylactic mucosal SARS-COV-2 vaccine to provide protection against Omicron infection in upper and lower respiratory tracts.

Abstract: Embodiments of the present disclosure generally relate to methods for forming a waveguide. Methods may include measuring a waveguide substrate, the waveguide having a substrate thickness distribution; and depositing an index-matched layer onto a surface of the waveguide, the index-matched layer having a first surface disposed on the waveguide substrate and a second surface opposing the first surface, wherein the index-matched layer is disposed only over a portion of the waveguide substrate, and a device slope of a second surface of the index-matched layer is substantially the same as the waveguide slope of the first surface of the waveguide.

Abstract: Embodiments of the present disclosure generally relate to methods for forming a waveguide. Methods may include measuring a waveguide substrate, the waveguide having a substrate thickness distribution; and depositing an index-matched layer onto a surface of the waveguide, the index-matched layer having a first surface disposed on the waveguide substrate and a second surface opposing the first surface, wherein the index-matched layer is disposed only over a portion of the waveguide substrate, and a device slope of a second surface of the index-matched layer is substantially the same as the waveguide slope of the first surface of the waveguide.

Abstract: A method of processing an optical device is provided, including: positioning an optical device on a substrate support in an interior volume of a process chamber, the optical device including an optical device substrate and a plurality of optical device structures formed over the optical device substrate, each optical device structure including a bulk region formed of silicon carbide and one or more surface regions formed of silicon oxycarbide. The method further includes providing one or more process gases to the interior volume of the process chamber, and generating a plasma of the one or more process gases in the interior volume for a first time period when the optical device is on the substrate support, and stopping the plasma after the first time period. A carbon content of the one or more surface regions of each optical device structure is reduced by at least 50% by the plasma.

Abstract: The present disclosure provides an optical waveguide design of a fiber modified with a thin layer of epsilon-near-zero (ENZ) material. The design results in an excitation of a highly confined waveguide mode in the fiber near the wavelength where permittivity of thin layer approaches zero. Due to the high field confinement within thin layer, the ENZ mode can be characterized by a peak in modal loss of the hybrid waveguide. Results show that such in-fiber excitation of ENZ mode is due to the coupling of the guided fundamental core mode to the thin-film ENZ mode. The phase matching wavelength, where the coupling takes place, varies depending on the refractive index of the constituents. These ENZ nanostructured optical fibers have many potential applications, for example, in ENZ nonlinear and magneto-optics, as in-fiber wavelength-dependent filters, and as subwavelength fluid channel for optical and bio-photonic sensing.

Abstract: An image segmentation method includes: obtaining an image to be segmented containing a target object; performing at least one image feature fusion processing on associated feature points based on the image to be segmented, and extracting global feature information during each image feature fusion processing, wherein the associated feature points are at least two feature points having a location association relation; and determining, based on the global feature information extracted, a segmentation mask for the target object.

Abstract: Various methods and systems are provided for x-ray imaging. In one embodiment, a method for an image pasting examination comprises acquiring, via an optical camera and/or depth camera, image data of a subject, controlling an x-ray source and an x-ray detector according to the image data to acquire a plurality of x-ray images of the subject, and stitching the plurality of x-ray images into a single x-ray image. In this way, optimal exposure techniques may be used for individual acquisitions in an image pasting examination such that the optimal dose is utilized, stitching quality is improved, and registration failures are avoided.

Abstract: The present disclosure relates to an imaging system and method. Specifically, an imaging system comprises: a positioning image acquisition unit, configured to acquire a positioning image of a scanning object; a monitoring slice image acquisition unit, configured to determine a key point corresponding to the position of a target region of interest in the positioning image by using a neural network, and acquire a monitoring slice image of the scanning object at the position of the key point; and a target region-of-interest segmentation unit, configured to segment the monitoring slice image to obtain the target region of interest. The present disclosure can accurately acquire the position of the monitoring slice, and can accurately obtain the target region of interest through segmentation by a cascaded coarse segmentation and fine segmentation.

Abstract: The present disclosure provides an optical waveguide design of a fiber modified with a thin layer of epsilon-near-zero (ENZ) material. The design results in an excitation of a highly confined waveguide mode in the fiber near the wavelength where permittivity of thin layer approaches zero. Due to the high field confinement within thin layer, the ENZ mode can be characterized by a peak in modal loss of the hybrid waveguide. Results show that such in-fiber excitation of ENZ mode is due to the coupling of the guided fundamental core mode to the thin-film ENZ mode. The phase matching wavelength, where the coupling takes place, varies depending on the refractive index of the constituents. These ENZ nanostructured optical fibers have many potential applications, for example, in ENZ nonlinear and magneto-optics, as in-fiber wavelength-dependent filters, and as subwavelength fluid channel for optical and bio-photonic sensing.

Abstract: The present application discloses a conductive membrane and a preparation method thereof, which belong to the field of membrane separation technology. The conductive membrane provided by the present application includes a porous base layer film, a porous intermediate layer film, and a porous conductive layer film which are disposed layer by layer in sequence; wherein at least some holes of the base layer film are communicated with holes of the conductive layer film through holes of the intermediate layer film, and material of the intermediate layer film is the same as material of the base layer film and of the conductive layer film. Regarding the conductive membrane provided by the present application, it can be coupled with electrochemical technology, so that the membrane exhibits new excellent properties at the same time of playing separating characteristic.

Abstract: Various methods and systems are provided for x-ray imaging. In one embodiment, a method for an image pasting examination comprises acquiring, via an optical camera and/or depth camera, image data of a subject, controlling an x-ray source and an x-ray detector according to the image data to acquire a plurality of x-ray images of the subject, and stitching the plurality of x-ray images into a single x-ray image. In this way, optimal exposure techniques may be used for individual acquisitions in an image pasting examination such that the optimal dose is utilized, stitching quality is improved, and registration failures are avoided.

Abstract: The present disclosure provides a system and method for an ultrathin optical metasurface with an array patterning formed on an optical fiber facet that enables manipulation of light passing therethrough, such as focusing and steering the light, and controlling a polarization state of light. The patterning can be non-uniform to selectively direct light passing through the metasurface. Array structures can vary in size, angle, shapes, and other non-uniform aspects. Further, the array can include materials that can be electrically activated and controlled to variably tune the metasurface characteristics for increased ability to manipulate the light passing therethrough. The materials can include a conductor, a dielectric, or a composite of a conductor, insulator, and dielectric formed on the optical fiber.

Abstract: The present disclosure provides an optical waveguide design of a fiber modified with a thin layer of epsilon-near-zero (ENZ) material. The design results in an excitation of a highly confined waveguide mode in the fiber near the wavelength where permittivity of thin layer approaches zero. Due to the high field confinement within thin layer, the ENZ mode can be characterized by a peak in modal loss of the hybrid waveguide. Results show that such in-fiber excitation of ENZ mode is due to the coupling of the guided fundamental core mode to the thin-film ENZ mode. The phase matching wavelength, where the coupling takes place, varies depending on the refractive index of the constituents. These ENZ nanostructured optical fibers have many potential applications, for example, in ENZ nonlinear and magneto-optics, as in-fiber wavelength-dependent filters, and as subwavelength fluid channel for optical and bio-photonic sensing.

Abstract: The present disclosure provides a system and method for an ultrathin optical metasurface with an array patterning formed on an optical fiber facet that enables manipulation of light passing therethrough, such as focusing and steering the light, and controlling a polarization state of light. The patterning can be non-uniform to selectively direct light passing through the metasurface. Array structures can vary in size, angle, shapes, and other non-uniform aspects. Further, the array can include materials that can be electrically activated and controlled to variably tune the metasurface characteristics for increased ability to manipulate the light passing therethrough. The materials can include a conductor, a dielectric, or a composite of a conductor, insulator, and dielectric formed on the optical fiber.

Abstract: A respiratory syncytial virus (RSV) vaccine comprising a recombinant fusion protein antigen. In one embodiment, the recombinant fusion protein antigen comprises a phosphoprotein (P) moiety, wherein the P moiety is a polypeptide that shares at least 90% identity to the polypeptide represented by SEQ ID NO 2 or SEQ ID NO 4; and a flagellin moiety, wherein the flagellin moiety is a polypeptide that shares at least 90% identity to the polypeptide represented by SEQ ID NO 8; whereby the P moiety and flagellin moiety are covalently coupled so as to form a linear polypeptide.

Abstract: A respiratory syncytial virus (RSV) vaccine comprising a recombinant fusion protein antigen. In one embodiment, the recombinant fusion protein antigen comprises a phosphoprotein (P) moiety, wherein the P moiety is a polypeptide that shares at least 90% identity to the polypeptide represented by SEQ ID NO 2 or SEQ ID NO 4; and a flagellin moiety, wherein the flagellin moiety is a polypeptide that shares at least 90% identity to the polypeptide represented by SEQ ID NO 8; whereby the P moiety and flagellin moiety are covalently coupled so as to form a linear polypeptide.