Patents by Inventor Jing Yong Ye
Jing Yong Ye has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11892397Abstract: A pyrogenicity test method and assay of endotoxins allows for rapid and ultrahigh sensitivity testing of parenteral pharmaceuticals or medical devices that contact blood or cerebrospinal fluid by employing a Limulus Amoebocyte Lysate (LAL) assay monitored with a photonic-crystal biosensor. The photonic-crystal biosensor is capable of determining the presence of endotoxins in a test sample by detecting shifts in the resonant condition of an open microcavity affected by the changes in the refractive index of the analyte solutions used.Type: GrantFiled: May 10, 2021Date of Patent: February 6, 2024Assignee: Board of Regents, The University of Texas SystemInventors: Jing Yong Ye, Jonathan D. Scudder
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Publication number: 20210262924Abstract: A pyrogenicity test method and assay of endotoxins allows for rapid and ultrahigh sensitivity testing of parenteral pharmaceuticals or medical devices that contact blood or cerebrospinal fluid by employing a Limulus Amoebocyte Lysate (LAL) assay monitored with a photonic-crystal biosensor. The photonic-crystal biosensor is capable of determining the presence of endotoxins in a test sample by detecting shifts in the resonant condition of an open microcavity affected by the changes in the refractive index of the analyte solutions used.Type: ApplicationFiled: May 10, 2021Publication date: August 26, 2021Inventors: Jing Yong Ye, Jonathan D. Scudder
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Patent number: 11099189Abstract: A pyrogenicity test assay and method of pyrogen testing that allows for rapid and ultrahigh sensitivity testing of parenteral pharmaceuticals or medical devices that contact blood or cerebrospinal fluid by employing a Limulus Amoebocyte Lysate (LAL) assay utilizing a photonic-crystal biosensor. The photonic-crystal biosensor is capable of determining the presence of endotoxins in a test sample by monitoring shifts in the resonant wavelength of an open microcavity affected by the changes in the refractive index of the analyte solutions used.Type: GrantFiled: October 16, 2018Date of Patent: August 24, 2021Assignee: Board of Regents, the University of Texas SystemInventors: Jing Yong Ye, Jonathan D. Scudder
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Patent number: 10842384Abstract: In one embodiment, a temperature sensor includes an optical waveguide having a distal tip and a thermochromic sensing element mounted to the distal tip of the optical waveguide, wherein light transmitted through the optical waveguide to the distal tip is reflected back from the thermochromic sensing element and wherein the reflected light provides an indication of a local temperature at a location of the thermochromic sensing element.Type: GrantFiled: January 12, 2018Date of Patent: November 24, 2020Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Jing Yong Ye, Corinne Nawn
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Publication number: 20190113514Abstract: A pyrogenicity test assay and method of pyrogen testing that allows for rapid and ultrahigh sensitivity testing of parenteral pharmaceuticals or medical devices that contact blood or cerebrospinal fluid by employing a Limulus Amoebocyte Lysate (LAL) assay utilizing a photonic-crystal biosensor. The photonic-crystal biosensor is capable of determining the presence of endotoxins in a test sample by monitoring shifts in the resonant wavelength of an open microcavity affected by the changes in the refractive index of the analyte solutions used.Type: ApplicationFiled: October 16, 2018Publication date: April 18, 2019Inventors: Jing Yong Ye, Jonathan D. Scudder
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Patent number: 10157483Abstract: Various examples are provided for photoacoustic image reconstruction and processing utilizing a backprojection approach. In one example, among others, a method for producing an image with a photoacoustic imaging system includes scanning an object with a plurality of light beams, detecting a plurality of acoustic signals produced by the light beams, and generating a reconstructed image from the plurality of acoustic signals by filtered backprojection (FBP) that utilizes a weighted ramp filter. In another example, a system includes a plurality of acoustic detector units and a processing unit. The acoustic detector units can receive an acoustic wave and convert it to time dependent electrical signals. The processing unit can reconstruct an image of the subject from the time-dependent electrical signals by FBP that utilizes a weighted ramp filter. In another example, non-transitory computer readable medium stores a program that can cause a processing unit to reconstruct an image.Type: GrantFiled: December 19, 2014Date of Patent: December 18, 2018Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: He Huang, Jing Yong Ye
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Publication number: 20180192887Abstract: In one embodiment, a temperature sensor includes an optical waveguide having a distal tip and a thermochromic sensing element mounted to the distal tip of the optical waveguide, wherein light transmitted through the optical waveguide to the distal tip is reflected back from the thermochromic sensing element and wherein the reflected light provides an indication of a local temperature at a location of the thermochromic sensing element.Type: ApplicationFiled: January 12, 2018Publication date: July 12, 2018Applicant: Board of Regents, The University of Texas SystemInventors: Jing Yong Ye, Corinne Nawn
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Publication number: 20150178959Abstract: Various examples are provided for photoacoustic image reconstruction and processing utilizing a backprojection approach. In one example, among others, a method for producing an image with a photoacoustic imaging system includes scanning an object with a plurality of light beams, detecting a plurality of acoustic signals produced by the light beams, and generating a reconstructed image from the plurality of acoustic signals by filtered backprojection (FBP) that utilizes a weighted ramp filter. In another example, a system includes a plurality of acoustic detector units and a processing unit. The acoustic detector units can receive an acoustic wave and convert it to time dependent electrical signals. The processing unit can reconstruct an image of the subject from the time-dependent electrical signals by FBP that utilizes a weighted ramp filter. In another example, non-transitory computer readable medium stores a program that can cause a processing unit to reconstruct an image.Type: ApplicationFiled: December 19, 2014Publication date: June 25, 2015Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: He Huang, Jing Yong Ye
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Publication number: 20140255985Abstract: An endscopic imaging device is described that achieves longitudinal axis (z-axis) scanning into a tissue or sample, using a piezoelectric microactuator. In some configurations, additional lateral (xy-plane) scanning is also achieved, to allow for the creation of full three-dimensional imaging, ex vivo or in vivo. The techniques may be used to image and diagnosis allergic rhinitis and eosinophilic esophagitis in tissue.Type: ApplicationFiled: May 20, 2014Publication date: September 11, 2014Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Kenn Oldham, Thomas D. Wang, Zhongyao Liu, Jing Yong Ye
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Patent number: 8807801Abstract: An endoscopic imaging device is described that achieves longitudinal axis (z-axis) scanning into a tissue or sample, using a piezoelectric microactuator. In some configurations, additional lateral (xy-plane) scanning is also achieved, to allow for the creation of full three-dimensional imaging, ex vivo or in vivo. The techniques may be used to image and diagnosis allergic rhinitis and eosinophilic esophagitis in tissue.Type: GrantFiled: January 23, 2012Date of Patent: August 19, 2014Assignee: The Regents of the University of MichiganInventors: Kenn Oldham, Thomas D. Wang, Zhongyao Liu, Jing Yong Ye
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Patent number: 8486371Abstract: A method and apparatus of multi-dye analysis of particles using flow cytometer. The method includes dying particles to be detected using two or more dyes; urging the particles through a capillary in a non-uniform flow; exciting a first of the particles within the capillary using a multiphoton excitation laser beam causing the two or more dyes each to fluoresce thereby producing a first output signal and a second output signal respectively; and detecting the first output signal and the second output signal. A second of the particles within the capillary being excited using the multiphoton excitation laser beam causing the two or more dyes each to fluoresce thereby producing a third output signal and a forth output signal respectively. The method finally includes comparing a ratio of the first output signal and the second output signal to a ratio of the third output signal and the forth output signal to detect a desired change in the particles.Type: GrantFiled: September 16, 2005Date of Patent: July 16, 2013Assignee: The Regents of The University of MichiganInventors: Jing Yong Ye, Theodore B. Norris, Cheng Frank Zhong, James R. Baker
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Publication number: 20120270256Abstract: An endscopic imaging device is described that achieves longitudinal axis (z-axis) scanning into a tissue or sample, using a piezoelectric microactuator. In some configurations, additional lateral (xy-plane) scanning is also achieved, to allow for the creation of full three-dimensional imaging, ex vivo or in vivo. The techniques may be used to image and diagnosis allergic rhinitis and eosinophilic esophagitis in tissue.Type: ApplicationFiled: January 23, 2012Publication date: October 25, 2012Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Kenn Oldham, Thomas D. Wang, Zhongyao Liu, Jing Yong Ye
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Patent number: 7639362Abstract: A photonic crystal sensor for outputting an output signal using a light source. The photonic crystal sensor includes a photonic crystal structure and a defect member disposed adjacent the photonic crystal structure. The defect member defines an operative surface. An input light signal from the light source is inputted to the photonic crystal structure and defect member and is internally reflected to thereby output the output signal. Also, the output signal relates to a condition at the operative surface.Type: GrantFiled: July 25, 2007Date of Patent: December 29, 2009Assignee: The Regents of the University of MichiganInventors: Jing Yong Ye, Yunbo Guo, Theodore B. Norris, James R. Baker, Jr.
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Patent number: 7474919Abstract: An additive, preferably in the form of metal nanoparticles or nanodomains, greatly improves a laser-based method and system for inducing optical breakdown. The use of ultrashort laser pulses to induce laser-induced breakdown (LIB) in metal nanoparticles or nanocomposites makes it possible to reduce significantly the threshold laser energy required for LIB. Such nanoscale (submicron) metallic particles allows one to control the LIB process. The nanoparticles can be synthesized so as to target specific biological structures or tissues (dendrimer nanoparticles are one system for which this has been demonstrated). This opens up the possibility of performing LIB for targeted cancer treatment or microsurgery.Type: GrantFiled: August 8, 2003Date of Patent: January 6, 2009Assignee: The Regents of the University of MichiganInventors: Jing Yong Ye, Theodore B. Norris, James R. Baker, Jr., Lajos P. Balogh
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Publication number: 20080292555Abstract: A method and apparatus of multi-dye analysis of particles using flow cytometer. The method includes dying particles to be detected using two or more dyes; urging the particles through a capillary in a non-uniform flow; exciting a first of the particles within the capillary using a multiphoton excitation laser beam causing the two or more dyes each to fluoresce thereby producing a first output signal and a second output signal respectively; and detecting the first output signal and the second output signal. A second of the particles within the capillary being excited using the multiphoton excitation laser beam causing the two or more dyes each to fluoresce thereby producing a third output signal and a forth output signal respectively. The method finally includes comparing a ratio of the first output signal and the second output signal to a ratio of the third output signal and the forth output signal to detect a desired change in the particles.Type: ApplicationFiled: September 16, 2005Publication date: November 27, 2008Inventors: Jing Yong Ye, Theodore B. Norris, Cheng F. Zhong, James R. Baker
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Publication number: 20080225293Abstract: A photonic crystal sensor for outputting an output signal using a light source. The photonic crystal sensor includes a photonic crystal structure and a defect member disposed adjacent the photonic crystal structure. The defect member defines an operative surface. An input light signal from the light source is inputted to the photonic crystal structure and defect member and is internally reflected to thereby output the output signal. Also, the output signal relates to a condition at the operative surface.Type: ApplicationFiled: July 25, 2007Publication date: September 18, 2008Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Jing Yong Ye, Yunbo Guo, Theodore B. Norris, James R. Baker
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Patent number: 7367948Abstract: An acoustic monitoring method and system in laser-induced optical breakdown (LIOB) provides information which characterize material which is broken down, microbubbles in the material, and/or the microenvironment of the microbubbles. In one embodiment of the invention, femtosecond laser pulses are focused just inside the surface of a volume of aqueous solution which may include dendrimer nanocomposite (DNC) particles. A tightly focused, high frequency, single-element ultrasonic transducer is positioned such that its focus coincides axially and laterally with this laser focus. When optical breakdown occurs, a microbubble forms and a shock or pressure wave is emitted (i.e., acoustic emission). In addition to this acoustic signal, the microbubble may be actively probed with pulse-echo measurements from the same transducer. After the microbubble forms, received pulse-echo signals have an extra pulse, describing the microbubble location and providing a measure of axial microbubble size.Type: GrantFiled: August 19, 2003Date of Patent: May 6, 2008Assignee: The Regents of the University of MichiganInventors: Matthew O'Donnell, Jing Yong Ye, Theodore B. Norris, James R. Baker, Jr., Lajos P. Balogh, Susanne M. Milas, Stanislav Y. Emelianov, Kyle W. Hollman
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Patent number: 7362500Abstract: A scanning microscope having a laser outputting an excitation laser beam and a fiber member having a first core and a second core. The second core is generally disposed within the first core and is operable to receive the excitation laser beam from the laser and transmit the excitation laser beam to a sample to be tested. A moveable stage supports an end of the fiber member and/or a sample to be tested and is operable to move the end of the fiber member and the sample to be tested relative to each other.Type: GrantFiled: May 28, 2004Date of Patent: April 22, 2008Assignee: The Regents of the University of MichiganInventors: Jing Yong Ye, Theodore B. Norris
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Patent number: 7277169Abstract: A fluorescence detection system for testing a sample having at least one fluorophore. The fluorescence detection system comprises a white light generation system outputting a white light pulse. The white light pulse has a first frequency range and a first time duration. The white light pulse excites the at least one fluorophore of the sample to emit a fluorescence. The fluorescence has a second frequency range and a second time duration, wherein the first time duration is less than the second time duration. A time-resolving detector receives the fluorescence and at least a portion of the white light pulse and separates the fluorescence from the portion of the white light pulse.Type: GrantFiled: February 16, 2006Date of Patent: October 2, 2007Assignee: The Regents of the University of MichiganInventors: Jing Yong Ye, Theodore B. Norris, James R. Baker, Jr.
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Patent number: 7236673Abstract: An optical fiber for use in fiber optic sensing of a test sample includes a first core and a second core. The second core is generally coaxially disposed within the first core and is sized smaller than the first core. The second core is capable of delivering pulsed laser energy from the laser for nonlinear optical excitation of the test sample. Nonlinear optical feedback signals can then be collected in both the first core and second core for improved detection efficiency relative to conventional single-mode and multi-mode fibers.Type: GrantFiled: March 9, 2006Date of Patent: June 26, 2007Assignee: The Regents of the University of MichiganInventors: Jing Yong Ye, Theodore Norris, James R. Baker, Jr., Thomas Thommey, Mon Myaing