Patents by Inventor Jing Yong Ye

Jing Yong Ye has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10842384
    Abstract: In one embodiment, a temperature sensor includes an optical waveguide having a distal tip and a thermochromic sensing element mounted to the distal tip of the optical waveguide, wherein light transmitted through the optical waveguide to the distal tip is reflected back from the thermochromic sensing element and wherein the reflected light provides an indication of a local temperature at a location of the thermochromic sensing element.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: November 24, 2020
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Jing Yong Ye, Corinne Nawn
  • Publication number: 20190113514
    Abstract: A pyrogenicity test assay and method of pyrogen testing that allows for rapid and ultrahigh sensitivity testing of parenteral pharmaceuticals or medical devices that contact blood or cerebrospinal fluid by employing a Limulus Amoebocyte Lysate (LAL) assay utilizing a photonic-crystal biosensor. The photonic-crystal biosensor is capable of determining the presence of endotoxins in a test sample by monitoring shifts in the resonant wavelength of an open microcavity affected by the changes in the refractive index of the analyte solutions used.
    Type: Application
    Filed: October 16, 2018
    Publication date: April 18, 2019
    Inventors: Jing Yong Ye, Jonathan D. Scudder
  • Patent number: 10157483
    Abstract: Various examples are provided for photoacoustic image reconstruction and processing utilizing a backprojection approach. In one example, among others, a method for producing an image with a photoacoustic imaging system includes scanning an object with a plurality of light beams, detecting a plurality of acoustic signals produced by the light beams, and generating a reconstructed image from the plurality of acoustic signals by filtered backprojection (FBP) that utilizes a weighted ramp filter. In another example, a system includes a plurality of acoustic detector units and a processing unit. The acoustic detector units can receive an acoustic wave and convert it to time dependent electrical signals. The processing unit can reconstruct an image of the subject from the time-dependent electrical signals by FBP that utilizes a weighted ramp filter. In another example, non-transitory computer readable medium stores a program that can cause a processing unit to reconstruct an image.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: December 18, 2018
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: He Huang, Jing Yong Ye
  • Publication number: 20180192887
    Abstract: In one embodiment, a temperature sensor includes an optical waveguide having a distal tip and a thermochromic sensing element mounted to the distal tip of the optical waveguide, wherein light transmitted through the optical waveguide to the distal tip is reflected back from the thermochromic sensing element and wherein the reflected light provides an indication of a local temperature at a location of the thermochromic sensing element.
    Type: Application
    Filed: January 12, 2018
    Publication date: July 12, 2018
    Applicant: Board of Regents, The University of Texas System
    Inventors: Jing Yong Ye, Corinne Nawn
  • Publication number: 20150178959
    Abstract: Various examples are provided for photoacoustic image reconstruction and processing utilizing a backprojection approach. In one example, among others, a method for producing an image with a photoacoustic imaging system includes scanning an object with a plurality of light beams, detecting a plurality of acoustic signals produced by the light beams, and generating a reconstructed image from the plurality of acoustic signals by filtered backprojection (FBP) that utilizes a weighted ramp filter. In another example, a system includes a plurality of acoustic detector units and a processing unit. The acoustic detector units can receive an acoustic wave and convert it to time dependent electrical signals. The processing unit can reconstruct an image of the subject from the time-dependent electrical signals by FBP that utilizes a weighted ramp filter. In another example, non-transitory computer readable medium stores a program that can cause a processing unit to reconstruct an image.
    Type: Application
    Filed: December 19, 2014
    Publication date: June 25, 2015
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: He Huang, Jing Yong Ye
  • Publication number: 20140255985
    Abstract: An endscopic imaging device is described that achieves longitudinal axis (z-axis) scanning into a tissue or sample, using a piezoelectric microactuator. In some configurations, additional lateral (xy-plane) scanning is also achieved, to allow for the creation of full three-dimensional imaging, ex vivo or in vivo. The techniques may be used to image and diagnosis allergic rhinitis and eosinophilic esophagitis in tissue.
    Type: Application
    Filed: May 20, 2014
    Publication date: September 11, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Kenn Oldham, Thomas D. Wang, Zhongyao Liu, Jing Yong Ye
  • Patent number: 8807801
    Abstract: An endoscopic imaging device is described that achieves longitudinal axis (z-axis) scanning into a tissue or sample, using a piezoelectric microactuator. In some configurations, additional lateral (xy-plane) scanning is also achieved, to allow for the creation of full three-dimensional imaging, ex vivo or in vivo. The techniques may be used to image and diagnosis allergic rhinitis and eosinophilic esophagitis in tissue.
    Type: Grant
    Filed: January 23, 2012
    Date of Patent: August 19, 2014
    Assignee: The Regents of the University of Michigan
    Inventors: Kenn Oldham, Thomas D. Wang, Zhongyao Liu, Jing Yong Ye
  • Patent number: 8486371
    Abstract: A method and apparatus of multi-dye analysis of particles using flow cytometer. The method includes dying particles to be detected using two or more dyes; urging the particles through a capillary in a non-uniform flow; exciting a first of the particles within the capillary using a multiphoton excitation laser beam causing the two or more dyes each to fluoresce thereby producing a first output signal and a second output signal respectively; and detecting the first output signal and the second output signal. A second of the particles within the capillary being excited using the multiphoton excitation laser beam causing the two or more dyes each to fluoresce thereby producing a third output signal and a forth output signal respectively. The method finally includes comparing a ratio of the first output signal and the second output signal to a ratio of the third output signal and the forth output signal to detect a desired change in the particles.
    Type: Grant
    Filed: September 16, 2005
    Date of Patent: July 16, 2013
    Assignee: The Regents of The University of Michigan
    Inventors: Jing Yong Ye, Theodore B. Norris, Cheng Frank Zhong, James R. Baker
  • Publication number: 20120270256
    Abstract: An endscopic imaging device is described that achieves longitudinal axis (z-axis) scanning into a tissue or sample, using a piezoelectric microactuator. In some configurations, additional lateral (xy-plane) scanning is also achieved, to allow for the creation of full three-dimensional imaging, ex vivo or in vivo. The techniques may be used to image and diagnosis allergic rhinitis and eosinophilic esophagitis in tissue.
    Type: Application
    Filed: January 23, 2012
    Publication date: October 25, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Kenn Oldham, Thomas D. Wang, Zhongyao Liu, Jing Yong Ye
  • Patent number: 7639362
    Abstract: A photonic crystal sensor for outputting an output signal using a light source. The photonic crystal sensor includes a photonic crystal structure and a defect member disposed adjacent the photonic crystal structure. The defect member defines an operative surface. An input light signal from the light source is inputted to the photonic crystal structure and defect member and is internally reflected to thereby output the output signal. Also, the output signal relates to a condition at the operative surface.
    Type: Grant
    Filed: July 25, 2007
    Date of Patent: December 29, 2009
    Assignee: The Regents of the University of Michigan
    Inventors: Jing Yong Ye, Yunbo Guo, Theodore B. Norris, James R. Baker, Jr.
  • Patent number: 7474919
    Abstract: An additive, preferably in the form of metal nanoparticles or nanodomains, greatly improves a laser-based method and system for inducing optical breakdown. The use of ultrashort laser pulses to induce laser-induced breakdown (LIB) in metal nanoparticles or nanocomposites makes it possible to reduce significantly the threshold laser energy required for LIB. Such nanoscale (submicron) metallic particles allows one to control the LIB process. The nanoparticles can be synthesized so as to target specific biological structures or tissues (dendrimer nanoparticles are one system for which this has been demonstrated). This opens up the possibility of performing LIB for targeted cancer treatment or microsurgery.
    Type: Grant
    Filed: August 8, 2003
    Date of Patent: January 6, 2009
    Assignee: The Regents of the University of Michigan
    Inventors: Jing Yong Ye, Theodore B. Norris, James R. Baker, Jr., Lajos P. Balogh
  • Publication number: 20080292555
    Abstract: A method and apparatus of multi-dye analysis of particles using flow cytometer. The method includes dying particles to be detected using two or more dyes; urging the particles through a capillary in a non-uniform flow; exciting a first of the particles within the capillary using a multiphoton excitation laser beam causing the two or more dyes each to fluoresce thereby producing a first output signal and a second output signal respectively; and detecting the first output signal and the second output signal. A second of the particles within the capillary being excited using the multiphoton excitation laser beam causing the two or more dyes each to fluoresce thereby producing a third output signal and a forth output signal respectively. The method finally includes comparing a ratio of the first output signal and the second output signal to a ratio of the third output signal and the forth output signal to detect a desired change in the particles.
    Type: Application
    Filed: September 16, 2005
    Publication date: November 27, 2008
    Inventors: Jing Yong Ye, Theodore B. Norris, Cheng F. Zhong, James R. Baker
  • Publication number: 20080225293
    Abstract: A photonic crystal sensor for outputting an output signal using a light source. The photonic crystal sensor includes a photonic crystal structure and a defect member disposed adjacent the photonic crystal structure. The defect member defines an operative surface. An input light signal from the light source is inputted to the photonic crystal structure and defect member and is internally reflected to thereby output the output signal. Also, the output signal relates to a condition at the operative surface.
    Type: Application
    Filed: July 25, 2007
    Publication date: September 18, 2008
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Jing Yong Ye, Yunbo Guo, Theodore B. Norris, James R. Baker
  • Patent number: 7367948
    Abstract: An acoustic monitoring method and system in laser-induced optical breakdown (LIOB) provides information which characterize material which is broken down, microbubbles in the material, and/or the microenvironment of the microbubbles. In one embodiment of the invention, femtosecond laser pulses are focused just inside the surface of a volume of aqueous solution which may include dendrimer nanocomposite (DNC) particles. A tightly focused, high frequency, single-element ultrasonic transducer is positioned such that its focus coincides axially and laterally with this laser focus. When optical breakdown occurs, a microbubble forms and a shock or pressure wave is emitted (i.e., acoustic emission). In addition to this acoustic signal, the microbubble may be actively probed with pulse-echo measurements from the same transducer. After the microbubble forms, received pulse-echo signals have an extra pulse, describing the microbubble location and providing a measure of axial microbubble size.
    Type: Grant
    Filed: August 19, 2003
    Date of Patent: May 6, 2008
    Assignee: The Regents of the University of Michigan
    Inventors: Matthew O'Donnell, Jing Yong Ye, Theodore B. Norris, James R. Baker, Jr., Lajos P. Balogh, Susanne M. Milas, Stanislav Y. Emelianov, Kyle W. Hollman
  • Patent number: 7362500
    Abstract: A scanning microscope having a laser outputting an excitation laser beam and a fiber member having a first core and a second core. The second core is generally disposed within the first core and is operable to receive the excitation laser beam from the laser and transmit the excitation laser beam to a sample to be tested. A moveable stage supports an end of the fiber member and/or a sample to be tested and is operable to move the end of the fiber member and the sample to be tested relative to each other.
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: April 22, 2008
    Assignee: The Regents of the University of Michigan
    Inventors: Jing Yong Ye, Theodore B. Norris
  • Patent number: 7277169
    Abstract: A fluorescence detection system for testing a sample having at least one fluorophore. The fluorescence detection system comprises a white light generation system outputting a white light pulse. The white light pulse has a first frequency range and a first time duration. The white light pulse excites the at least one fluorophore of the sample to emit a fluorescence. The fluorescence has a second frequency range and a second time duration, wherein the first time duration is less than the second time duration. A time-resolving detector receives the fluorescence and at least a portion of the white light pulse and separates the fluorescence from the portion of the white light pulse.
    Type: Grant
    Filed: February 16, 2006
    Date of Patent: October 2, 2007
    Assignee: The Regents of the University of Michigan
    Inventors: Jing Yong Ye, Theodore B. Norris, James R. Baker, Jr.
  • Patent number: 7236673
    Abstract: An optical fiber for use in fiber optic sensing of a test sample includes a first core and a second core. The second core is generally coaxially disposed within the first core and is sized smaller than the first core. The second core is capable of delivering pulsed laser energy from the laser for nonlinear optical excitation of the test sample. Nonlinear optical feedback signals can then be collected in both the first core and second core for improved detection efficiency relative to conventional single-mode and multi-mode fibers.
    Type: Grant
    Filed: March 9, 2006
    Date of Patent: June 26, 2007
    Assignee: The Regents of the University of Michigan
    Inventors: Jing Yong Ye, Theodore Norris, James R. Baker, Jr., Thomas Thommey, Mon Myaing
  • Patent number: 7046888
    Abstract: An optical fiber for use in fiber optic sensing of a test sample includes a first core and a second core. The second core is generally coaxially disposed within the first core and is sized smaller than the first core. The second core is capable of delivering pulsed laser energy from the laser for nonlinear optical excitation of the test sample. Nonlinear optical feedback signals can then be collected in both the first core and second core for improved detection efficiency relative to conventional single-mode and multi-mode fibers.
    Type: Grant
    Filed: December 17, 2003
    Date of Patent: May 16, 2006
    Assignee: The Regents of the University of Michigan
    Inventors: Jing Yong Ye, Theodore Norris, James R. Baker, Jr., Thomas Thommey, Mon Myaing
  • Publication number: 20040131322
    Abstract: An optical fiber for use in fiber optic sensing of a test sample includes a first core and a second core. The second core is generally coaxially disposed within the first core and is sized smaller than the first core. The second core is capable of delivering pulsed laser energy from the laser for nonlinear optical excitation of the test sample. Nonlinear optical feedback signals can then be collected in both the first core and second core for improved detection efficiency relative to conventional single-mode and multi-mode fibers.
    Type: Application
    Filed: December 17, 2003
    Publication date: July 8, 2004
    Inventors: Jing Yong Ye, Theodore Norris, James R. Baker, Thomas Thommey, Mon Myaing
  • Publication number: 20040043081
    Abstract: An additive, preferably in the form of metal nanoparticles or nanodomains, greatly improves a laser-based method and system for inducing optical breakdown. The use of ultrashort laser pulses to induce laser-induced breakdown (LIB) in metal nanoparticles or nanocomposites makes it possible to reduce significantly the threshold laser energy required for LIB. Such nanoscale (submicron) metallic particles allows one to control the LIB process. The nanoparticles can be synthesized so as to target specific biological structures or tissues (dendrimer nanoparticles are one system for which this has been demonstrated). This opens up the possibility of performing LIB for targeted cancer treatment or microsurgery.
    Type: Application
    Filed: August 8, 2003
    Publication date: March 4, 2004
    Applicant: The Regents of the University of Michigan
    Inventors: Jing Yong Ye, Theodore B. Norris, James R. Baker, Lajos P. Balogh