Patents by Inventor Jing Yu Jin

Jing Yu Jin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240116853
    Abstract: 2-hydroxy-5-[2-(4-(trifluoromethylphenyl)ethylamino)]benzoic acid crystal forms and a preparation method therefor are proposed. Crystal form I is a monoclinic crystal system, which has a Pc space group and can be obtained by slow cooling, evaporating the solvent at a constant temperature, evaporating the solvent at an increased temperature, or adding an anti-solvent. Crystal form II is a triclinic crystal system, which has a P1 space group and can be obtained by rapid cooling or freeze-drying. According to the method, the process is simple, costs are low, and the yield exceeds 90%; and the crystal forms of the crystal forms I and II have high purity, the crystal shapes thereof are intact, and have excellent fluidity, facilitating preparation, particularly the preparation of a pharmaceutical preparation for preventing and/or treating degenerative diseases of the central nervous system. Furthermore, the two crystal forms have a better apparent solubility than that of raw materials.
    Type: Application
    Filed: December 6, 2021
    Publication date: April 11, 2024
    Inventors: Xinliang XU, Guoqing ZHANG, Chenghan ZHUANG, Lei WANG, Byoung Joo GWAG, Chun San AHN, Jing Yu JIN
  • Publication number: 20240051915
    Abstract: A method for preparing 2-hydroxy-5-[2-(4-(trifluoromethylphenyl)ethylamino)]benzoic acid is proposed. The method may include protection, condensation, and hydrolysis. By means of the screening of a hydroxyl protecting reagent for a starting material, for example, 2-(4-trifluoromethyl)phenethylalcohol and the optimization of other process parameters, the contents of meta-isomer impurities and disubstituted impurities in a target product are effectively controlled. Accordingly, the quality of the product is significantly improved, the reaction yield is also greatly improved, and the improved product quality can satisfy related requirements of preparation research.
    Type: Application
    Filed: December 6, 2021
    Publication date: February 15, 2024
    Inventors: Xinliang XU, Chenghan ZHUANG, Lei WANG, Xin LU, Bo ZHANG, Byoung Joo GWAG, Chun San AHN, Jing Yu JIN
  • Publication number: 20230390231
    Abstract: The present invention relates to pharmaceutical compositions and methods for treating ischemic stroke in humans, using a tetrafluorobenzyl derivative of formula (I) or a pharmaceutically acceptable salt thereof conjointly with a thrombolytic drug, endovascular thrombectomy, or both (e.g., endovascular thrombectomy and a thrombolytic drug). Administration of a tetrafluorobenzyl derivative of formula (I) or its pharmaceutically acceptable salt can reduce reperfusion injury and other adverse events in patients conjointly receiving a thrombolytic drug, endovascular thrombectomy, or endovascular thrombectomy with a thrombolytic drug.
    Type: Application
    Filed: August 21, 2023
    Publication date: December 7, 2023
    Inventors: Byoung Joo GWAG, Chun San An, Jing Yu Jin, Sung Ig Cho, Fangmeng Zhu, Xinliang Xu, Weiqiang Zhan, Fuxin Liu, Soon-Mi Won
  • Patent number: 11826329
    Abstract: The present invention relates to pharmaceutical compositions and methods for treating ischemic stroke in humans, using a tetrafluorobenzyl derivative of formula (I) or a pharmaceutically acceptable salt thereof conjointly with a thrombolytic drug, endovascular thrombectomy, or both (e.g., endovascular thrombectomy and a thrombolytic drug). Administration of a tetrafluorobenzyl derivative of formula (I) or its pharmaceutically acceptable salt can reduce reperfusion injury and other adverse events in patients conjointly receiving a thrombolytic drug, endovascular thrombectomy, or endovascular thrombectomy with a thrombolytic drug.
    Type: Grant
    Filed: March 10, 2021
    Date of Patent: November 28, 2023
    Assignee: GNT Pharma Co., Ltd.
    Inventors: Byoung Joo Gwag, Chun San An, Jing Yu Jin, Sung Ig Cho, Fangmeng Zhu, Xinliang Xu, Weiqiang Zhan, Fuxin Liu, Soon-Mi Won
  • Publication number: 20210283080
    Abstract: The present invention relates to pharmaceutical compositions and methods for treating ischemic stroke in humans, using a tetrafluorobenzyl derivative of formula (I) or a pharmaceutically acceptable salt thereof conjointly with a thrombolytic drug, endovascular thrombectomy, or both (e.g., endovascular thrombectomy and a thrombolytic drug). Administration of a tetrafluorobenzyl derivative of formula (I) or its pharmaceutically acceptable salt can reduce reperfusion injury and other adverse events in patients conjointly receiving a thrombolytic drug, endovascular thrombectomy, or endovascular thrombectomy with a thrombolytic drug.
    Type: Application
    Filed: March 10, 2021
    Publication date: September 16, 2021
    Inventors: Byoung Joo Gwag, Chun San An, Jing Yu Jin, Sung Ig Cho, Fangmeng Zhu, Xinliang Xu, Weiqiang Zhan, Fuxin Liu, Soon-Mi Won