Abstract: An application of a channel blocker in preparation of drugs for treating and/or preventing liver fibrosis is provided, belonging to the field of biomedical technology. A new use of phenytoin sodium is provided. It is demonstrated that at the cell level, the phenytoin sodium can improve liver fibrosis by regulating autophagy and thus affecting the activation of hepatic stellate cells. In this situation, the efficacy of the phenytoin sodium on liver fibrosis is verified at the animal level by establishing a disease model, and the phenytoin sodium can be used to prepare drugs for treating and/or preventing liver fibrosis.

Abstract: An ion channel blocker for treatment and/or prevention of hepatic fibrosis is provided. Based on the fact that the activation of hepatic stellate cells is an important link in anti-hepatic fibrosis, it is found that gliclazide has the effect of inhibiting the activation of hepatic stellate cells by in vitro and in vivo experiments. Further exploration reveals that gliclazide mainly inhibits the activation of hepatic stellate cells by inhibiting autophagy pathways, and thus the gliclazide can be used to prepare medicaments for treatment and/or prevention of hepatic fibrosis.

Abstract: An application of potassium ion (K+) channel blocker in preparation of drugs for treating liver fibrosis is provided, which relates to the field of medical technologies. The K+ channel blocker is sotalol, the sotalol is originally used as an antiarrhythmic drug in clinic and has a property of inhibiting K+ channels. Experiments show that sotalol can effectively inhibit liver fibrosis and reduce expression of fibrosis-related protein alpha-smooth muscle actin (?-SMA), specifically by regulating expression and/or function of autophagy and epithelial-mesenchymal transition (EMT) molecules to achieve inhibition of hepatic stellate cell (HSC) fibrosis, so as to provide a new drug choice for clinical treatment of the liver fibrosis.

Abstract: A method for pushing a resource includes obtaining a collection of users to which a resource is to be pushed, in which the collection includes a plurality of users; obtaining respective predicted conversion rates of the resource for the plurality of users; obtaining user groups by dividing the plurality of users into groups based on respective predicted conversion rates for the plurality of users, in which the user groups correspond to different conversion rate ranges; and for each user group, selecting a target user from the user group based on a real conversion rate related to pushed users corresponding to the conversion rate range of the user group, and pushing the resource to the target user.

Abstract: A method of processing a feature information is provided, which relates to a field of data processing, in particular to fields of artificial intelligence and big data. The method includes: determining at least one candidate division point in a value range of the feature information, and determining an information value corresponding to each candidate division point; determining a target division point based on the information value; dividing the value range based on the target division point, so as to obtain two sub-ranges; determining a sub-range meeting a termination condition in the two sub-ranges as a target interval, determining a sub-range not meeting the termination condition in the two sub-ranges as a new value range, and returning to perform the step of determining at least one candidate division point in a value range until both sub-ranges meet the termination condition, so as to obtain a plurality of target intervals.

Abstract: A method for pushing a resource includes obtaining a collection of users to which a resource is to be pushed, in which the collection includes a plurality of users; obtaining respective predicted conversion rates of the resource for the plurality of users; obtaining user groups by dividing the plurality of users into groups based on respective predicted conversion rates for the plurality of users, in which the user groups correspond to different conversion rate ranges; and for each user group, selecting a target user from the user group based on a real conversion rate related to pushed users corresponding to the conversion rate range of the user group, and pushing the resource to the target user.

Abstract: The independent claims of this patent signify a concise description of embodiments. Embodiments described herein are directed to a database-driven scheme for automating the process of VDRC checking in a full-custom EDA Design and Implementation tool.

Abstract: Techniques for analyzing a routed interconnection of a net of a circuit are discussed herein. Some embodiments may include a method comprising with a computer, analyzing the circuit to determine a performance parameter of the net, wherein the circuit is analyzed based at least in part on applying pre-layout simulation data of the net to layout data of the circuit. Additionally or alternatively, the circuit may be analyzed based on extracting characteristics of the routed interconnection from the layout data of the net.

Abstract: The independent claims of this patent signify a concise description of embodiments. Embodiments described herein are directed to a database-driven scheme for automating the process of VDRC checking in a full-custom EDA Design and Implementation tool.

Abstract: Systems and techniques are described for determining a resistance of a conducting structure. The conducting structure can be partitioned into a set of polygons based on (1) equipotential lines and (2) boundaries of the conducting structure. Next, a matrix equation can be constructed, wherein for at least one polygon in the set of polygons, electric potentials of boundary elements on the boundaries of the polygon are represented by linear combinations of electric potentials of two or more equipotential lines. The resistance of the conducting structure can then be determined by solving the matrix equation.

Abstract: The present invention discloses a cyclone generator for a pipeline type oil-water separator which separates oil from water using the principle of cyclone. The cyclone generator comprises: flow deflectors which are fixedly arranged along the circumferential direction of a pipe to generate, when an oil-water mixture flows through the flow deflectors, a centrosymmetric cyclone field to centrifugally separate oil from water. The present invention further discloses an oil-water separation device which uses the aforementioned principle, the mixture of oil and water flowing through the device forms a centrosymmetric cyclone field in which an oil core is distributed in the central area of a pipe without shifting significantly so as to achieve an excellent oil-water separation effect.

Abstract: Systems and techniques are described for determining a resistance of a conducting structure. The conducting structure can be partitioned into a set of polygons based on (1) equipotential lines and (2) boundaries of the conducting structure. Next, a matrix equation can be constructed, wherein for at least one polygon in the set of polygons, electric potentials of boundary elements on the boundaries of the polygon are represented by linear combinations of electric potentials of two or more equipotential lines. The resistance of the conducting structure can then be determined by solving the matrix equation.

Abstract: Techniques for analyzing a routed interconnection of a net of a circuit are discussed herein. Some embodiments may include a method comprising with a computer, analyzing the circuit to determine a performance parameter of the net, wherein the circuit is analyzed based at least in part on applying pre-layout simulation data of the net to layout data of the circuit. Additionally or alternatively, the circuit may be analyzed based on extracting characteristics of the routed interconnection from the layout data of the net.

Abstract: Techniques for analyzing a routed interconnection of a net of a circuit are discussed herein. Some embodiments may include a method comprising with a computer, analyzing the circuit to determine a performance parameter of the net, wherein the circuit is analyzed based at least in part on applying pre-layout simulation data of the net to layout data of the circuit. Additionally or alternatively, the circuit may be analyzed based on extracting characteristics of the routed interconnection from the layout data of the net.

Abstract: Described nucleic acid molecules (and corresponding peptides) encode lyso-phosphatidylcholine (LPC) acyltransferases. Over-expression of the LPC acyltransferases in a cell may lead to enhanced production of PUFA, or other unusual fatty acids, and/or to increased oil content in the cell.

Abstract: The present disclosure relates to the isolation, purification, and characterization of a diacylglycerol acyltransferase 2 (DGAT2), and genes encoding DGAT2, from algae. DGAT2 can incorporate very long-chain polyunsaturated fatty acids into triacylglycerol more efficiently than DGAT1. The disclosure concerns methods of regulating seed oil content, fatty acid synthesis and fatty acid composition using the DGAT2 gene and to tissues and plants transformed with the gene. The disclosure also relates to transgenic plants, plant tissues and plant seeds having a genome containing an introduced DNA sequence of the disclosure, and a method of producing such plants and plant seeds.

Abstract: The present disclosure relates to the isolation, purification, and characterization of a diacylglycerol acyltransferase 2 (DGAT2), and genes encoding DGAT2, from algae. DGAT2 can incorporate very long-chain polyunsaturated fatty acids into triacylglycerol more efficiently than DGAT1. The disclosure concerns methods of regulating seed oil content, fatty acid synthesis and fatty acid composition using the DGAT2 gene and to tissues and plants transformed with the gene. The disclosure also relates to transgenic plants, plant tissues and plant seeds having a genome containing an introduced DNA sequence of the disclosure, and a method of producing such plants and plant seeds.

Abstract: The present invention discloses a cyclone generator for a pipeline type oil-water separator which separates oil from water using the principle of cyclone. The cyclone generator comprises: flow deflectors which are fixedly arranged along the circumferential direction of a pipe to generate, when an oil-water mixture flows through the flow deflectors, a centrosymmetric cyclone field to centrifugally separate oil from water. The present invention further discloses an oil-water separation device which uses the aforementioned principle, the mixture of oil and water flowing through the device forms a centrosymmetric cyclone field in which an oil core is distributed in the central area of a pipe without shifting significantly so as to achieve an excellent oil-water separation effect.

Abstract: The present disclosure relates to the isolation, purification, and characterization of a diacylglycerol acyltransferase 2 (DGAT2), and genes encoding DGAT2, from algae. DGAT2 can incorporate very long chain polyunsaturated fatty acids in to triacylglycerol more efficiently than DGAT1. The disclosure concerns methods of regulating seed oil content, fatty acid synthesis and fatty acid composition using the DGAT2 gene and to tissues and plants transformed with the gene. The disclosure also relates to transgenic plants, plant tissues and plant seeds having a genome containing an introduced DNA sequence of the disclosure, and a method of producing such plants and plant seeds.

Abstract: One embodiment of the present invention provides a system that generates a pattern-clip-based hotspot database for performing automatic pattern-clip-based layout verification. During operation, the system receives a list of pattern clips which specify manufacturing hotspots to be avoided in a layout, wherein each pattern clip comprises a set of geometries in proximity to each other. Next, for each pattern clip, the system perturbs the pattern clip to determine a first range of variations for the constituent set of geometries wherein the perturbed pattern clip no longer causes a manufacturing hotspot. The system then extracts a set of correction guidance descriptions from the first range of variations for correcting the pattern clip. Subsequently, the system stores the pattern clip and the set of correction guidance descriptions in the pattern-clip-based hotspot database.