Abstract: A glycosylation method involving a trivalent iodine reagent, wherein a glycosyl donor (I) is activated in the presence of a trivalent iodine reagent and a transition metal catalyst, and then reacts with a acceptor (II) under acid catalysis or directly to obtain a glycosylation product (III); in the glycosyl donor (I), Gly is a glycosyl group in which one or more hydroxyl groups on the sugar ring are protected by a protecting group; X is an oxygen, sulfur, or selenium atom; R is an alkyl group or an aryl group; the acceptor (II) is a nucleophile selected from sugars, alcohols, phenols, flavonoids, carboxylic acids, phosphates, pyrimidines, purines, amides, sulfonamides, guanidines, arylamines, indoles, enol silyl ethers, thiols, or thiophenol containing one or more free hydroxyl groups.

Abstract: A glycosylation method involving a trivalent iodine reagent, wherein a glycosyl donor (I) is activated in the presence of a trivalent iodine reagent and a transition metal catalyst, and then reacts with a acceptor (II) under acid catalysis or directly to obtain a glycosylation product (III); in the glycosyl donor (I), Gly is a glycosyl group in which one or more hydroxyl groups on the sugar ring are protected by a protecting group; X is an oxygen, sulfur, or selenium atom; R is an alkyl group or an aryl group; the acceptor (II) is a nucleophile selected from sugars, alcohols, phenols, flavonoids, carboxylic acids, phosphates, pyrimidines, purines, amides, sulfonamides, guanidines, arylamines, indoles, enol silyl ethers, thiols, or thiophenol containing one or more free hydroxyl groups.

Abstract: Some examples herein include systems and methods of creating standards of gemstones of various classifications, which may display certain characteristics of the various classifications when excited by ultraviolet radiation and fluoresce in response. In some examples, a set of standards are created using fluorescent material, filters, and a radiation source to compare against a sample gemstone. In some examples, specific Light Emitting Diodes are selected to illuminate the gemstone samples under analysis.

Abstract: Provided herein are methods and compositions for increasing fetal hemoglobin levels in a cell by disrupting BCL11A expression at the genomic level. Also provided herein are methods and compositions relating to the treatment of hemoglobinopathies by reinduction of fetal hemoglobin levels.

Abstract: The present disclosure provides a flight anti-collision method and apparatus based on electromagnetic field detection of an overhead transmission line. An example method includes: determining whether an overhead transmission line around is an Alternating Current (AC) transmission line or a (Direct Current) DC transmission line; if the overhead transmission line is an AC transmission line, determining a position relationship between an aircraft and the overhead transmission line on the basis of a phase distribution model and an electric field phase and a magnetic field phase measured by a phase detector on the aircraft; if the overhead transmission line around is a DC transmission line, determining the position relationship between the aircraft and the overhead transmission line on the basis of a magnetic field intensity distribution model and the magnetic field intensities collected by magnetic field intensity sensors on the aircraft; and thus controlling the aircraft.

Abstract: The present invention relates to an antioxidant culture method and antioxidant auxiliary equipment. The antioxidant cultivation method comprises: providing an electrolytic hydrogen generator comprising an anode, a cathode and a membrane between the cathode and the anode, the electrolytic hydrogen generator being connected with a bioreactor; inputting the culture medium in the bioreactor to the cathode and inputting a pure water to the anode; and providing an electric current to the electrolytic hydrogen generator to output a hydrogen from the cathode so as to dissolve the hydrogen in the culture medium of the bioreactor.

Abstract: A ROCK inhibitor represented by formula (I), and a preparation method therefor and a use thereof are provided. The ROCK inhibitor has excellent ROCK inhibition activity, particularly shows good selective inhibition on ROCK2 kinase, has good safety and metabolic stability, and is high in bioavailability. The preparation method for the ROCK inhibitor is simple, and the ROCK inhibitor is easy to purify, and therefore has a good application prospect.

Abstract: An application of a compound using intra-cyclic peroxo-bridged sesquiterpenes as a parent nucleus in metabolism-related fatty liver diseases is provided. The compound using intra-cyclic peroxo-bridged sesquiterpenes as the parent nucleus has the structure shown in Formula I, where A denotes O, —OH, OCH3, —OCH2CH3, or —OC4H5O3. The compound using intra-cyclic peroxo-bridged sesquiterpenes as the parent nucleus is configured for preparing a drug or a composition for treating metabolism-related fatty liver diseases. The present invention demonstrates that the compound using intra-cyclic peroxo-bridged sesquiterpenes as the parent nucleus can improve the function of mitochondria. in liver cells and enhance the fatty acid ?-oxidation capacity thereof and can be used for the treatment of metabolic dysfunction due to mitochondrial dysfunction, as well as the resulting liver fat accumulation, inflammation, and fibrotic lesions.

Abstract: Provided herein are 2?-O-methyl 3?phosphorothioate (MS)-modified synthetic nucleic acid molecules (single guide RNAs (sgRNAs)) in combination with a base editor as a ribonucleoprotein (RNP) complex for an electroporation-based ex vivo targeted gene disruption of the BCL11A erythroid enhancer's +55, +58, or +62, functional regions. Also provided herein are methods relating to the treatment of hemoglobinopathies by reinduction of fetal hemoglobin levels.

Abstract: Some examples herein include systems and methods of creating standards of gemstones of various classifications, which may display certain characteristics of the various classifications when excited by ultraviolet radiation and fluoresce in response. In some examples, a set of standards are created using fluorescent material, filters, and a radiation source to compare against a sample gemstone. In some examples, specific Light Emitting Diodes are selected to illuminate the gemstone samples under analysis.

Abstract: A casing hanger and annulus sealing device running tool for deepwater drilling and a method for using the same. The running tool includes a spindle connected to a hollow suspension structure via a torque transmission structure, one end of the spindle slidably passes through a hollow piston, the suspension structure rotates with the spindle and slide along the piston, the inner cavity of the torque transmission structure communicates with that of the suspension structure to form a piston cavity; the piston cavity and the piston form a hydraulic piston structure; and one end of the suspension structure away from the torque transmission structure can rotatably hook to and lift upward to release the annulus sealing device, and one end of the piston away from the torque transmission structure can radially expand to hook to the casing hanger and can radially contract to release the casing hanger.

Abstract: The present invention provides an ascorbate peroxidase mutant MaAPX1M36K and an application thereof, belonging to the technical field of biotechnology. An amino acid sequence of the mutant MaAPX1M36K of the present invention is shown in SEQ ID NO. 3. In the present invention, the mutant MaAPX1M36K reconstruction protein is obtained by the method of prokaryotic expression. It is found that the mutant MaAPX1M36K improves catalytic efficiency by nearly 5 times, providing a technical reference for further study and application of APX1.

Abstract: The present disclosure discloses a method and a device for measuring flatness of a flexible photovoltaic module, comprising: a measurement platform configured to fix a to-be-measured flexible photovoltaic module, height measurers respectively corresponding to wave crests and wave troughs on the to-be-measured flexible photovoltaic module, the plurality of height measurers being located above the measurement platform, and a lift rack on which the plurality of height measurers are disposed.

Abstract: Provided are a device and method for detecting a photovoltaic module. An exemplary device for detecting a photovoltaic module may comprise a light source and a projection display unit provided on opposite sides of a photovoltaic module to be detected, respectively. Further, the projection display unit may be configured to display a projection of the photovoltaic module to be detected, generated under illumination of the light source. In devices and methods for detecting a photovoltaic module provided by embodiments herein, under illumination of the light source, the projection of the photovoltaic module to be detected may be displayed on the projection display unit, and bent corner(s) of the photovoltaic module to be detected can also be clearly displayed, which enables an accurate and quick selection of defective photovoltaic modules. Moreover, the removal of the defective photovoltaic modules greatly increases production yield of final products assembled from the photovoltaic modules.

Abstract: A wet leakage current test system for a photovoltaic component is disclosed having a liquid pool and a voltage-withstanding insulation tester as well as a first storage rack, a lifting actuator, a second storage rack, a drying apparatus and an electrical protection device; the first storage rack is arranged above the liquid pool, and is mechanically connected with the lifting actuator; the lifting actuator is configured to drive the first storage rack to descend into the liquid pool or ascend above the liquid pool; the drying apparatus is mounted on the second storage rack, for blowing air to a front surface and a back surface of the photovoltaic component laid flat on the second storage rack; and the electrical protection device is in electrical signal connection with the voltage-withstanding insulation tester, for disabling a voltage output from the voltage-withstanding insulation tester in the case that the operator operates in a high voltage region, and/or for cutting off a power source of the voltage-wit

Abstract: A water distribution system with wide-range variable traffic includes a water distribution tank and at least two types of spray heads uniformly distributed on the bottom of the water distribution tank. Each spray head is provided with a spray pipe connected to the bottom of the water distribution tank. A water inlet is arranged on the upper part of each spray pipe, and a water outlet is arranged on the lower part of the spray pipe. The heights, by which water inlets of at least two types of spray heads are exposed out of the bottom of the water distribution tank, are different.

Abstract: Provided herein are synthetic nucleic acids that encode a CRISPR enzyme fused to a series of nuclear localization signal sequences for the use of altering expression of a gene in a cell. Further provided herein are methods for altering gene expression in a cell comprising introducing the synthetic nucleic acids and a guide RNA, or a polypeptide and a guide RNA into a cell. In certain embodiments the cell is a quiescent cell, for example, a hematopoietic stem cell.

Abstract: Provided herein are methods and compositions for increasing fetal hemoglobin levels in a cell by disrupting BCL11A expression at the genomic level. Also provided herein are methods and compositions relating to the treatment of hemoglobinopathies by reinduction of fetal hemoglobin levels.

Abstract: A casing hanger and annulus sealing device running tool for deepwater drilling and a method for using the same. The running tool includes a spindle connected to a hollow suspension structure via a torque transmission structure, one end of the spindle slidably passes through a hollow piston, the suspension structure rotates with the spindle and slide along the piston, the inner cavity of the torque transmission structure communicates with that of the suspension structure to form a piston cavity; the piston cavity and the piston form a hydraulic piston structure; and one end of the suspension structure away from the torque transmission structure can rotatably hook to and lift upward to release the annulus sealing device, and one end of the piston away from the torque transmission structure can radially expand to hook to the casing hanger and can radially contract to release the casing hanger.

Abstract: The present disclosure relates to an retroreflective structural colour film and a preparation method thereof. The main steps are as follows: (1) assembling colloidal microspheres to form a monolayer of microspheres; and (2) transferring the monolayer of microspheres onto a transparent substrate which has an adhesive layer to make the monolayer of microspheres partially embedded in the adhesive layer to prepare the retroreflective structural colour film. The retroreflective material has the advantages of the simple preparation process, high reflective brightness and uniformity of reflection colour. Moreover, the retroreflective material can exhibit unique retroreflective structural colour under the illumination of a white light source.