Abstract: The present disclosure provides methods for inducing neoepitope-specific CD8+ T cells in an individual or for inducing trafficking of neoepitope-specific CD8+ T cells to a tumor in an individual using an RNA vaccine or using an RNA vaccine in combination with a PD-1 axis binding antagonist. Also provided herein are PD-1 axis binding antagonists and RNA vaccines that include one or more polynucleotides encoding one or more neoepitopes resulting from cancer-specific somatic mutations present in a tumor specimen obtained from the individual for use in methods of inducing neoepitope-specific CD8+ T cells in an individual or for inducing trafficking of neoepitope-specific CD8+ T cells to a tumor in an individual.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for implementing a dossier interface and distributing the dossier are disclosed. In one aspect, a method includes the actions of receiving data identifying one or more documents to include in a dossier. The actions further include receiving a request to share the dossier with a first user. The actions further include providing a link to the dossier. The actions further include receiving a request to modify the dossier. The actions further include storing data that indicates the modification and maintaining the data identifying the one or more documents that represent the dossier. The actions further include receiving, from the first user, a request to share the dossier with a second user. The actions further include providing, to the second user, a link that identifies the dossier and the data that indicates the modification.

Abstract: A method (and system) includes retrieving a dataset from a database, creating a report including a representation of the dataset, the representation of the dataset including a data attribute and a data metric, displaying the report on a graphical user interface and providing a configurable selector adapted to adjust the attribute or the metric. The selector is configurable to target one or multiple representations of data on the report. The selector is configurable to add or replace attributes or metrics to the representation of the dataset.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for implementing a dossier interface and distributing the dossier are disclosed. In one aspect, a method includes the actions of receiving data identifying one or more documents to include in a dossier. The actions further include receiving a request to share the dossier with a first user. The actions further include providing a link to the dossier. The actions further include receiving a request to modify the dossier. The actions further include storing data that indicates the modification and maintaining the data identifying the one or more documents that represent the dossier. The actions further include receiving, from the first user, a request to share the dossier with a second user. The actions further include providing, to the second user, a link that identifies the dossier and the data that indicates the modification.

Abstract: The present invention relates to a method, an apparatus, and a system for protecting cloud data security. A key management center encrypts original data M sent by a first terminal using a key K, and uploads encrypted data C1 to a cloud server. When the key management center receives a request from a second terminal for the data M, it generates encrypted data C2, which is generated by first encrypting C1 with a key Kb of the second terminal and then decrypted by the key K that was used to encrypt the original data M to generate C1. The key management center then sends the encrypted data C2 to the second terminal. The second terminal decrypts the encrypted data C2 using its own key Kb to obtain the original data M.

Abstract: The present invention relates to a method, an apparatus, and a system for protecting cloud data security. A key management center encrypts original data M sent by a first terminal using a key K, and uploads encrypted data C1 to a cloud server. When the key management center receives a request from a second terminal for the data M, it generates encrypted data C2, which is generated by first encrypting C1 with a key Kb of the second terminal and then decrypted by the key K that was used to encrypt the original data M to generate C1. The key management center then sends the encrypted data C2 to the second terminal. The second terminal decrypts the encrypted data C2 using its own key Kb to obtain the original data M.