Patents by Inventor Jingen ZHU

Jingen ZHU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240067747
    Abstract: Provided is an isolated antigen-binding protein, which can specifically bind to CD73 and includes at least one CDR in a heavy chain variable region VH, wherein the region VH includes an amino acid sequence as represented by SEQ ID NO: 49.
    Type: Application
    Filed: January 12, 2022
    Publication date: February 29, 2024
    Inventors: Jingen XU, Xiangyang ZHU, Haijia YU, Xiaoyue WEI, Lili QU, Xiaochen REN
  • Publication number: 20230355738
    Abstract: A bacteriophage T4-based, multivalent/multicomponent, needle and adjuvant-free, mucosal vaccine by engineering spike trimers on capsid exterior and nucleocapsid protein in the interior is disclosed herein. Intranasal administration of this T4-COVID vaccine induces higher virus neutralization antibody titers against multiple variants, balanced Th1/Th2 antibody and cytokine responses, stronger CD4+ and CD8+ T cell immunity, and higher secretory IgA titers in sera and bronchoalveolar lavage with no effect on the gut microbiota, compared to vaccination of mice intramuscularly. The vaccine is stable at ambient temperature, induce apparent sterilizing immunity, and provide complete protection against original SARS-CoV-2 strain and its Delta variant with minimal lung histopathology. This mucosal vaccine is an excellent candidate for boosting immunity of immunized and/or as a second-generation vaccine for the unimmunized population.
    Type: Application
    Filed: April 24, 2023
    Publication date: November 9, 2023
    Inventors: Venigalla B. RAO, Jingen ZHU
  • Patent number: 11401530
    Abstract: Described is an “artificial virus” (AV) programmed with biomolecules that can enter human cells and carry out precise human genome modification. The AVs comprise: at least one viral vector, such as bacteriophage T4; at least one therapeutic molecule, such as DNA, RNA, protein and their complex; and a lipid coating. Also described is a method of human genome modification, using such an AV, and a method of program such an AV.
    Type: Grant
    Filed: June 28, 2021
    Date of Patent: August 2, 2022
    Assignee: The Catholic University of America
    Inventors: Venigalla B. Rao, Jingen Zhu
  • Publication number: 20220184205
    Abstract: The present disclosure relates to a system for and a method of incorporating SARS-CoV-2 genes and proteins into T4 phages. The present disclosure also relates to vaccine against SARS-CoV-2 containing recombinant T4 phages created using the method provided in the present disclosure.
    Type: Application
    Filed: December 13, 2021
    Publication date: June 16, 2022
    Inventors: Venigalla B. RAO, Jingen ZHU
  • Publication number: 20220090139
    Abstract: Described is an “artificial virus” (AV) programmed with biomolecules that can enter human cells and carry out precise human genome modification. The AVs comprise: at least one viral vector, such as bacteriophage T4; at least one therapeutic molecule, such as DNA, RNA, protein and their complex; and a lipid coating. Also described is a method of human genome modification, using such an AV, and a method of program such an AV.
    Type: Application
    Filed: December 9, 2021
    Publication date: March 24, 2022
    Inventors: Venigalla B. RAO, Jingen ZHU
  • Publication number: 20220033850
    Abstract: Described is an “artificial virus” (AV) programmed with biomolecules that can enter human cells and carry out precise human genome modification. The AVs comprise: at least one viral vector, such as bacteriophage T4; at least one therapeutic molecule, such as DNA, RNA, protein and their complex; and a lipid coating. Also described is a method of human genome modification, using such an AV, and a method of program such an AV.
    Type: Application
    Filed: June 28, 2021
    Publication date: February 3, 2022
    Inventors: Venigalla B. RAO, Jingen ZHU
  • Publication number: 20220010335
    Abstract: Described is hybrid viral vector comprising: a first virus such as bacteriophage T4; one or more second virus such as adeno-associated virus (AAV) attached to the first virus through cross-bridges, such as avidin-biotin cross-bridges; one or more DNA molecules packaged in the first virus; one or more nucleic acid molecules packaged in the second virus; and one or more proteins displayed on the surface of the first virus. Also described are methods of making and using such a hybrid viral vector.
    Type: Application
    Filed: September 29, 2021
    Publication date: January 13, 2022
    Inventors: Venigalla B. RAO, Jingen ZHU
  • Patent number: 11155835
    Abstract: Described is hybrid viral vector comprising: a first virus such as bacteriophage T4; one or more second virus such as adeno-associated virus (AAV) attached to the first virus through cross-bridges, such as avidin-biotin cross-bridges; one or more DNA molecules packaged in the first virus; one or more nucleic acid molecules packaged in the second virus; and one or more proteins displayed on the surface of the first virus. Also described are methods of making and using such a hybrid viral vector.
    Type: Grant
    Filed: August 11, 2020
    Date of Patent: October 26, 2021
    Assignee: The Catholic University of America
    Inventors: Venigalla B. Rao, Jingen Zhu
  • Publication number: 20210054410
    Abstract: Described is hybrid viral vector comprising: a first virus such as bacteriophage T4; one or more second virus such as adeno-associated virus (AAV) attached to the first virus through cross-bridges, such as avidin-biotin cross-bridges; one or more DNA molecules packaged in the first virus; one or more nucleic acid molecules packaged in the second virus; and one or more proteins displayed on the surface of the first virus. Also described are methods of making and using such a hybrid viral vector.
    Type: Application
    Filed: August 11, 2020
    Publication date: February 25, 2021
    Inventors: Venigalla B. RAO, Jingen ZHU