Publication number: 20030185815
Abstract: Disclosed herein are nucleic acid sequences that encode polypeptides. Also disclosed are antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids, polypeptides, or antibodies, or fragments thereof.
Type:
Application
Filed:
April 2, 2002
Publication date:
October 2, 2003
Inventors:
Muralidhara Padigaru, Suresh G. Shenoy, Ramesh Kekuda, Luca Rastelli, Peter D. Mezes, Glennda Smithson, Xiaojia Guo, Valerie Gerlach, Stacie J. Casman, Ferenc L. Boldog, Li Li, Bryan D. Zerhusen, Velizar T. Tchernev, Esha A. Gangolli, Corine A. M. Vernet, Kimberly A. Spytek, Uriel M. Malyankar, Meera Patturajan, Charles E. Miller, Raymond J. Taupier, Melvyn P. Heyes, Jingfang Ju, John A. Peyman, Elina Catterton, John R. MacDougall, Shlomit R. Edinger, David J. Stone, Ann Mazur
Publication number: 20030176385
Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of H-Ras, WNT-7B, acetylglucosaminyltransferase, voltage-gated K channel, IL-8, ion transport, Map3K8 and Thymidine kinase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding H-Ras, WNT-7B, acetylglucosaminyltransferase, voltage-gated K channel, IL-8, ion transport, Map3K8 and Thymidine kinase. Methods of using these compounds for modulation of H-Ras, WNT-7B, acetylglucosaminyltransferase, voltage-gated K channel, IL-8, ion transport, Map3K8 and Thymidine kinase.expression and for treatment of diseases associated with expression of H-Ras, WNT-7B, acetylglucosaminyltransferase, voltage-gated K channel, 1L-8, ion transport, Map3KS and Thymidine kinase are provided.
Type:
Application
Filed:
November 27, 2002
Publication date:
September 18, 2003
Inventors:
Jingfang Ju, Chunli Huang, Haihong Zhong, Jan Fredrik Simons, Bruce E. Taillon, John S. Chant, John A. Peyman, Glennda Smithson, Isabelle Millet