Abstract: The present application relates to a respiratory syncytial virus subtype A (RSV-A) recombinant F protein, a polynucleotide encoding the RSV-A recombinant F protein, a nucleic acid construct comprising the polynucleotide, an expression vector comprising the nucleic acid construct, a host cell into which the polynucleotide, the nucleic acid construct, or the expression vector is transformed or transfected, a stabilized trimer formed from the RSV-A recombinant F protein, an immunogenic composition comprising any of the foregoing, and use of any of the forgoing in the preparation of a vaccine for the prevention and/or treatment of respiratory syncytial virus infections. The RSV-A recombinant F protein comprises at least one epitope specific to the pre-fusion F protein, and can form a stable, pre-fusion conformation of F protein trimer. Furthermore, the RSV-A recombinant F protein can be expressed stably in a uniform form and with a significantly increased yield.

Abstract: The present application relates to a respiratory syncytial virus subtype B (RSV-B) recombinant F protein, a polynucleotide encoding the RSV-B recombinant F protein, a nucleic acid construct comprising the polynucleotide, an expression vector comprising the nucleic acid construct, a host cell into which the polynucleotide, the nucleic acid construct, or the expression vector is transformed or transfected, a stabilized trimer formed from the RSV-B recombinant F protein, an immunogenic composition comprising any of the foregoing, and use of any of the forgoing in the preparation of a vaccine for the prevention and/or treatment of respiratory syncytial virus infections. The RSV-B recombinant F protein comprises at least one epitope specific to the pre-fusion F protein, and can form a stable, pre-fusion conformation of F protein trimer. Furthermore, the RSV-B recombinant F protein can be expressed stably in a uniform form and with a significantly increased yield.

Abstract: Provided in the present disclosure are a Zika/dengue vaccine and its application thereof. The present disclosure introduces a mutation into the E-protein FL fusion region of the Zika virus or dengue virus. Antigens with said mutations are unable to bind to antibodies that causes ADE. After immunization with the vaccine of the present disclosure acquired from the said antigens, production of FL epitope-induced antibodies can be prevented, thereby reducing or eliminating the ADE effect.

Abstract: A method for checking a medium-term and long-term maintenance plan of a power grid. A predicted load value and one or more historical load values of a power grid are acquired and clustered through a clustering algorithm, and a historical moment at which a historical load value is in a same cluster as the predicted load value and has a largest load value is selected as a target historical moment. A power grid operation mode model at the target historical moment is acquired, and the power grid operation mode model is updated according to the maintenance plan and open loop point information by using a full wiring approach to obtain a future-state power grid operation mode model. Ground state power flow data of the power grid are calculated based on the operation mode model, and safety check is carried out according to a preset ground state power flow limit.

Abstract: Provided in the present invention are a humanized monoclonal antibody for the 2019 novel coronavirus (2019-nCOV) and the use thereof. The antibody is capable of specifically binding with a receptor binding domain (RBD) of 2019-nCOV and blocking the binding between the RBD of 2019-nCOV and ACE2, and furthermore inhibiting the infection caused by 2019-nCOV.

Abstract: The embodiments of the present disclosure relate to antigens of ?-coronaviruses, preparation methods and uses thereof. The amino acid sequence of the antigen of the ?-coronavirus includes an amino acid sequence arranged in a (A-B)-(A-B) pattern or an amino acid sequence arranged in a (A-B)-C-(A-B) pattern or an amino acid sequence arranged in a (A-B)-(A-B?) pattern or an amino acid sequence arranged in a (A-B)-C-(A-B?) pattern. The antigen of the ?-coronavirus has a single-chain dimer structure. A single-chain dirtier expressed according to examples of the present disclosure is stable in content and has excellent immunogenicity as an antigen of a ?-coronavirus, and a vaccine prepared by using the single-chain dimer as an antigen of a ?-coronavirus can elicit high-titer neutralizing antibodies in mice.

Abstract: The embodiments of the present disclosure relate to antigens of ?-coronaviruses, preparation methods and uses thereof. The amino acid sequence of the antigen of the ?-coronavirus includes an amino acid sequence arranged in a (A-B)-(A-B) pattern or an amino acid sequence arranged in a (A-B)-C-(A-B) pattern or an amino acid sequence arranged in a (A-B)-(A-B?) pattern or an amino acid sequence arranged in a (A-B)-C-(A-B?) pattern. The antigen of the ?-coronavirus has a single-chain dimer structure. A single-chain dirtier expressed according to examples of the present disclosure is stable in content and has excellent immunogenicity as an antigen of a ?-coronavirus, and a vaccine prepared by using the single-chain dimer as an antigen of a ?-coronavirus can elicit high-titer neutralizing antibodies in mice.

Abstract: Embodiments provide a method for constructing a future-state power grid model and device, including that: a current power grid model, an equipment power-off plan, an equipment retirement plan and an equipment addition plan are acquired; then, equipment is added according to the current power grid model, and an added equipment information set, a retired equipment information set and a powered-off equipment information set are determined according to the equipment addition plan, the equipment retirement plan and the equipment power-off plan respectively; and finally, a state of the added equipment is set to be an operating state, an initial network model of each period is formed according to a time sequence, and a future-state network model is constructed according to the added equipment information set, the retired equipment information set, the powered-off equipment information set and the initial network models. The embodiments further provide construction equipment and a storage medium.

Abstract: Embodiments provide a method for constructing a future-state power grid model and device, including that: a current power grid model, an equipment power-off plan, an equipment retirement plan and an equipment addition plan are acquired; then, equipment is added according to the current power grid model, and an added equipment information set, a retired equipment information set and a powered-off equipment information set are determined according to the equipment addition plan, the equipment retirement plan and the equipment power-off plan respectively; and finally, a state of the added equipment is set to be an operating state, an initial network model of each period is formed according to a time sequence, and a future-state network model is constructed according to the added equipment information set, the retired equipment information set, the powered-off equipment information set and the initial network models. The embodiments further provide construction equipment and a storage medium.