Patents by Inventor Jingkang Wang

Jingkang Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10604474
    Abstract: A method for preparing a new crystalline form of ?-aminobutyric acid, including the steps of: S1: preparing a ?-aminobutyric acid solution at an initial concentration of 0.5-1.0 g/mL by adding crude ?-aminobutyric acid to water; adding an additive to the ?-aminobutyric acid solution, raising the temperature to 50-80° C., stirring to produce a clear solution; and S2: obtaining a suspension by evaporating water from the product of S1 under reduced pressure and at 50-80° C.; obtaining a wet product by filtering the suspension; drying the wet product to obtain the new crystalline form of ?-aminobutyric acid. The preparation method of the new crystalline form of ?-aminobutyric acid is simple, easy to operate, low in energy consumption, economical and environmentally friendly. It is suitable for large-scale industrial production.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: March 31, 2020
    Assignees: Nantong Licheng Biological Engineering Co., Ltd, Tianjin University
    Inventors: Junbo Gong, Kaifei Zhao, Haiyan Xi, Xiaohua Wu, Baohong Hou, Qiuxiang Yin, Jingkang Wang, Feng Jin, Shichao Du, Qinqing Gu, Shiping Tang
  • Patent number: 10487044
    Abstract: The present invention discloses a ?-aminobutyric acid hemihydrate crystal, its molecular formula is C4H9NO2.0.5H2O. It also discloses a method of preparing a ?-aminobutyric acid hemihydrate crystal, including first adding crude ?-aminobutyric acid to water to prepare a ?-aminobutyric acid suspension at an initial concentration of 1.2-2.0 g/mL; then stirring the suspension at a constant temperature of 5-10° C. for 6-12 hours, followed by filtering and drying to obtain the ?-aminobutyric acid hemihydrate crystal. The ?-aminobutyric acid hemihydrate crystal is stable, does not easily absorb moisture and agglomerate, and is convenient for further processing and use. The crystal has a large main particle size, uniform particle size distribution, high bulk density, good flowability, and a purity of ?99%. The preparation method of the crystal according to the present invention is simple, easy to operate, highly efficient and low in energy consumption, and is suitable for large-scale industrial production.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: November 26, 2019
    Assignees: Nantong Licheng Biological Engineering Co., Ltd, Tianjin University
    Inventors: Junbo Gong, Qinqing Gu, Kaifei Zhao, Jiangbo Li, Baohong Hou, Qiuxiang Yin, Jingkang Wang, Yi Sun, Shichao Du, Xin Pan, Zhongshi Liu
  • Publication number: 20190225574
    Abstract: A method for preparing a new crystalline form of ?-aminobutyric acid, including the steps of: S1: preparing a ?-aminobutyric acid solution at an initial concentration of 0.5-1.0 g/mL by adding crude ?-aminobutyric acid to water; adding an additive to the ?-aminobutyric acid solution, raising the temperature to 50-80° C., stirring to produce a clear solution; and S2: obtaining a suspension by evaporating water from the product of S1 under reduced pressure and at 50-80° C.; obtaining a wet product by filtering the suspension; drying the wet product to obtain the new crystalline form of ?-aminobutyric acid. The preparation method of the new crystalline form of ?-aminobutyric acid is simple, easy to operate, low in energy consumption, economical and environmentally friendly. It is suitable for large-scale industrial production.
    Type: Application
    Filed: November 7, 2016
    Publication date: July 25, 2019
    Inventors: Junbo Gong, Kaifei Zhao, Haiyan Xi, Xiaohua Wu, Baohong Hou, Qiuxiang Yin, Jingkang Wang, Feng Jin, Shichao Du, Qinqing Gu, Shiping Tang
  • Publication number: 20180370901
    Abstract: The present invention discloses a ?-aminobutyric acid hemihydrate crystal, its molecular formula is C4H9NO2.0.5H2O. It also discloses a method of preparing a ?-aminobutyric acid hemihydrate crystal, including first adding crude ?-aminobutyric acid to water to prepare a ?-aminobutyric acid suspension at an initial concentration of 1.2-2.0 g/mL; then stirring the suspension at a constant temperature of 5-10° C. for 6-12 hours, followed by filtering and drying to obtain the ?-aminobutyric acid hemihydrate crystal. The ?-aminobutyric acid hemihydrate crystal is stable, does not easily absorb moisture and agglomerate, and is convenient for further processing and use. The crystal has a large main particle size, uniform particle size distribution, high bulk density, good flowability, and a purity of ?99%. The preparation method of the crystal according to the present invention is simple, easy to operate, highly efficient and low in energy consumption, and is suitable for large-scale industrial production.
    Type: Application
    Filed: November 11, 2016
    Publication date: December 27, 2018
    Inventors: Junbo Gong, Qinqing Gu, Kaifei Zhao, Jiangbo Li, Baohong Hou, Qiuxiang Yin, Jingkang Wang, Yi Sun, Shichao Du, Xin Pan, Zhongshi Liu
  • Publication number: 20180282297
    Abstract: The present application relates to polymorphs of Compound A: or a stereoisomer thereof, and methods of preparation and use thereof.
    Type: Application
    Filed: March 27, 2018
    Publication date: October 4, 2018
    Inventors: Junbo GONG, Lina JIA, Shuhao WEN, Jian MA, Jingkang WANG, Qiuxiang YIN, Baohong HOU, Lipeng LAI, Peiyu ZHANG, Mingjun YANG, Yang LIU, Guangxu SUN
  • Publication number: 20180111949
    Abstract: It discloses a new industrial crystallization method of Cefuroxime Sodium, wherein supercritical fluid extraction technology and traditional crystalline technology are combined to realize the recrystallization of Cefuroxime Sodium. Processes such as extraction, adsorption, crystallization and drying are carried out with a supercritical fluid, a solvent, an extraction cell and a crystallization tank to realize the recrystallization of Cefuroxime Sodium under a specific pressure at a specific temperature.
    Type: Application
    Filed: August 25, 2017
    Publication date: April 26, 2018
    Applicants: HAINAN LINGKANG PHARMACEUTICAL CO., LTD, TIANJIN UNIVERSITY
    Inventors: Linggang TAO, Hongxun HAO, Jingkang WANG
  • Publication number: 20170349609
    Abstract: A novel crystalline form is defined by diffraction angle 2?° of X-ray powder diffraction pattern and characteristic peak of differential scanning calorimetry (DSC). The novel crystalline form of Cefamandole Nafate is prepared as follows: adding Cefamandole Nafate in solid state to an organic solvent to form a suspension with a concentration of 0.04˜0.3 g/ml, stirring the suspension at 40˜50° C. for a period of time, and then cooling to 5˜15° C. at certain cooling rate, continuing to stir for a period of time, then suction filtrating the obtained suspension, the resulting filer cake is Cefamandole Nafate as wet product, which is dried to constant weight to provide the novel crystalline form of Cefamandole Nafate as final product.
    Type: Application
    Filed: August 25, 2017
    Publication date: December 7, 2017
    Applicants: TIANJIN UNIVERSITY, HAINAN LINGKANG PHARMACEUTICAL CO., LTD
    Inventors: Hongxun Hao, Linggang Tao, Fang He, Baohong Hou, Jingkang Wang, Jun Lv, Qiuxiang Yin, Yongli Wang, Junbo Gong, Chuang Xie, Ying Bao
  • Patent number: 9834567
    Abstract: A novel crystalline form is defined by diffraction angle 2?° of X-ray powder diffraction pattern and characteristic peak of differential scanning calorimetry (DSC). The novel crystalline form of Cefamandole Nafate is prepared as follows: adding Cefamandole Nafate in solid state to an organic solvent to form a suspension with a concentration of 0.04˜0.3 g/ml, stirring the suspension at 40˜50° C. for a period of time, and then cooling to 5˜15° C. at certain cooling rate, continuing to stir for a period of time, then suction filtrating the obtained suspension, the resulting filer cake is Cefamandole Nafate as wet product, which is dried to constant weight to provide the novel crystalline form of Cefamandole Nafate as final product.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: December 5, 2017
    Assignees: TIANJIN UNIVERSITY, HAINAN LINGKANG PHARMACEUTICAL CO., LTD
    Inventors: Hongxun Hao, Linggang Tao, Fang He, Baohong Hou, Jingkang Wang, Jun Lv, Qiuxiang Yin, Yongli Wang, Junbo Gong, Chuang Xie, Ying Bao
  • Patent number: 9815848
    Abstract: This invention provides a new preparation method of Clopidogrel Hydrogen Sulfate spherical crystal form I, using single 2-butanol as solvent, controlling the concentration, addition way and addition speed of sulfuric acid used to salify to shorten the process time, thus separating out Clopidogrel Hydrogen Sulfate from solution system stably with spherality. And the Clopidogrel Hydrogen Sulfate obtained complies with the requirements of the follow-up process on residual solvent, bulk density and mobility.
    Type: Grant
    Filed: December 31, 2014
    Date of Patent: November 14, 2017
    Assignees: TIANJIN UNIVERSITY, SHENZHEN SALUBRIS PHARMACEUTICALS CO., LTD
    Inventors: Junbo Gong, Qi Wang, Qiuxiang Yin, Jingkang Wang, Xiaopeng Song, Baohong Hou, Liting Liao, Duanming Tan, Ziyuan Di
  • Publication number: 20170197937
    Abstract: A novel crystalline form is defined by using diffraction angle 2?° of X-ray powder diffraction pattern and characteristic peaks of differential scanning calorimetry (DSC). Pantoprazole Sodium solid is added to an alcohol solvent to form a suspension with a concentration of 0.05˜0.2 g/mL, and then an antioxidant is added to the suspension, completely dissolving the solid at a temperature of 15˜35° C., and a solventing-out agent is dropwise added to the solution under the application of ultrasonic wave, wherein the amount of the solventing-out agent is 3˜10 times (in volume) of the alcohol solvent; followed by cooling the solution down to 0˜5° C., continuing to stir for 1˜3 h, and suction filtrating obtained solid-liquid suspension to provide a novel crystalline form of Pantoprazole Sodium crystal after drying the product to constant weight.
    Type: Application
    Filed: November 20, 2015
    Publication date: July 13, 2017
    Applicants: TIANJIN UNIVERSITY, HAINAN LINGKANG PHARMACEUTICAL CO., LTD
    Inventors: Hongxun HAO, Linggang TAO, Shen JIANG, Yongli WANG, Jingkang WANG, Jun LV, Qiuxiang YIN, Baohong HOU, Zhao XU, Chuang XIE, Zhao WANG
  • Publication number: 20170158711
    Abstract: It discloses a new industrial crystallization method of Cefuroxime Sodium, wherein supercritical fluid extraction technology and traditional crystalline technology are combined to realize the recrystallization of Cefuroxime Sodium. Processes such as extraction, adsorption, crystallization and drying are carried out with a supercritical fluid, a solvent, an extraction cell and a crystallization tank to realize the recrystallization of Cefuroxime Sodium under a specific pressure at a specific temperature.
    Type: Application
    Filed: November 27, 2015
    Publication date: June 8, 2017
    Applicants: HAINAN LINGKANG PHARMACEUTICAL CO., LTD., TIANJIN UNIVERSITY
    Inventors: Linggang TAO, Hongxun HAO, Jingkang WANG
  • Publication number: 20170050982
    Abstract: A novel crystalline form is defined by diffraction angle 2?° of X-ray powder diffraction pattern and characteristic peak of differential scanning calorimetry (DSC). The novel crystalline form of Cefamandole Nafate is prepared as follows: adding Cefamandole Nafate in solid state to an organic solvent to form a suspension with a concentration of 0.04˜0.3 g/ml, stirring the suspension at 40˜50° C. for a period of time, and then cooling to 5˜15° C. at certain cooling rate, continuing to stir for a period of time, then suction filtrating the obtained suspension, the resulting filer cake is Cefamandole Nafate as wet product, which is dried to constant weight to provide the novel crystalline form of Cefamandole Nafate as final product.
    Type: Application
    Filed: November 20, 2015
    Publication date: February 23, 2017
    Applicants: TIANJIN UNIVERSITY, HAINAN LINGKANG PHARMACEUTICAL CO., LTD
    Inventors: Hongxun HAO, Linggang TAO, Fang He, Baohong HOU, Jingkang WANG, Jun LV, Qiuxiang YIN, Yongli WANG, Junbo GONG, Chuang XIE, Ying Bao
  • Publication number: 20170037054
    Abstract: This invention provides a new preparation method of Clopidogrel Hydrogen Sulfate spherical crystal form I, using single 2-butanol as solvent, controlling the concentration, addition way and addition speed of sulfuric acid used to salify to shorten the process time, thus separating out Clopidogrel Hydrogen Sulfate from solution system stably with spherality. And the Clopidogrel Hydrogen Sulfate obtained complies with the requirements of the follow-up process on residual solvent, bulk density and mobility.
    Type: Application
    Filed: December 31, 2014
    Publication date: February 9, 2017
    Inventors: Junbo GONG, Qi WANG, Qiuxiang YIN, Jingkang WANG, Xiaopeng Song, Baohong HOU, Liting LIAO, Duanming TAN, Ziyuan DI
  • Patent number: 8178521
    Abstract: The present invention relates to cefazolin sodium pentahydrate crystal and a method for assembly and preparation of the crystal molecule. The cefazolin sodium pentahydrate crystal molecule contains five water molecules, orthorhombic system, space group of C222(1), in which sodium ion is bonded to the cefazolin molecule with a coordinate bond. The method for assembly and preparation of cefazolin sodium pentahydrate crystal molecule are: adding a solvent to a reactor equipped with a jacket, adding cefazolin acid and a sodium salt, heating until the reaction solution is clear, stirring continuously, adjusting pH, upon the completion of the reaction, transferring the liquid into a jacketed crystallizer, adding crystal seeds or nucleating spontaneously, controlling cooling, slowly adding a antisolvent.
    Type: Grant
    Filed: September 15, 2006
    Date of Patent: May 15, 2012
    Assignees: Tianjin University, Shenzhen Gosun Pharmaceutical Co., Ltd.
    Inventors: Jingkang Wang, Yuxin Qian, Meijing Zhang, Jiehua Wu, Zhan'ao Yang
  • Publication number: 20090299056
    Abstract: The present invention relates to cefazolin sodium pentahydrate crystal and a method for assembly and preparation of the crystal molecule. The cefazolin sodium pentahydrate crystal molecule contains five water molecules, orthorhombic system, space group of C222(1), in which sodium ion is bonded to the cefazolin molecule with a coordinate bond. The method for assembly and preparation of cefazolin sodium pentahydrate crystal molecule are: adding a solvent to a reactor equipped with a jacket, adding cefazolin acid and a sodium salt, heating until the reaction solution is clear, stirring continuously, adjusting pH, upon the completion of the reaction, transferring the liquid into a jacketed crystallizer, adding crystal seeds or nucleating spontaneously, controlling cooling, slowly adding a antisolvent.
    Type: Application
    Filed: September 15, 2006
    Publication date: December 3, 2009
    Inventors: Jingkang Wang, Yuxin Qian, Meijing Zhang, Jiehua Wu, Zhan'ao Yang
  • Publication number: 20090092662
    Abstract: A liposome composition comprised of liposomes having a peptide boronic acid proteasome inhibitor compound entrapped in the liposomes is described. More specifically, liposomes having a compound of Formula I or II entrapped in the interior aqueous compartment are loaded with a peptide boronic acid compound, to form a boronate ester compound inside the liposomal aqueous compartment. In one embodiment, the liposomes have an outer coating of hydrophilic polymer chains and are used to treat a solid tumor in a subject.
    Type: Application
    Filed: August 21, 2008
    Publication date: April 9, 2009
    Inventors: Anthony Huang, Bing Luo, Jingkang Wang, Yuanpeng Zhang