Patents by Inventor Jingnan LUO

Jingnan LUO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210069101
    Abstract: The present technology relates to depot assemblies for the controlled, sustained release of a therapeutic agent. The assembly can include a depot having a therapeutic region comprising a therapeutic agent, and a control region comprising a bioresorbable polymer and a releasing agent mixed with the polymer. The releasing agent may be configured to dissolve when the depot is placed in vivo to form diffusion openings in the control region. The depot may be configured to be implanted at a treatment site in vivo and, while implanted, release the therapeutic agent at the treatment site for no less than 3 days.
    Type: Application
    Filed: April 11, 2019
    Publication date: March 11, 2021
    Inventors: Karun D. Naga, Hanson S. Gifford, III, Stephen W. Boyd, Patrick H. Ruane, Jackie Joe Hancock, Michael Feldstein, Koon Kiat Teu, Honglei Wang, Jingnan Luo, Daniel Boon Lim Seet, Wei Li Lee, Nassireddin Mokarram-Dorri
  • Publication number: 20200368398
    Abstract: The devices, systems, and methods disclosed herein may be directed to a delivery system including a therapeutic member configured for endoluminal placement via the delivery system into the esophagus of the patient, wherein the therapeutic member comprises a treatment portion comprising a film for controlled release of a chemotherapeutic agent. The film may comprise a control region, a therapeutic region, and a substantially impermeable base region. The film is configured to release the chemotherapeutic agent in a direction away from the substantially impermeable base region. The delivery system is configured to enable a treatment provider to position the treatment portion of the therapeutic member proximate to a treatment site associated with the esophagus of the patient, and the therapeutic member is configured to administer a therapeutically effective dose to the treatment site for a sustained period following endoluminal placement of the therapeutic member.
    Type: Application
    Filed: January 8, 2019
    Publication date: November 26, 2020
    Inventors: Karun D. Naga, Stephen W. Boyd, Hanson S. Gifford, III, Mark Deem, John Morriss, Martin Mayse, Honglei Wang, Jingnan Luo, Daniel Boon Lim Seet, Koon Kiat Teu, Wei Li Lee
  • Publication number: 20200246255
    Abstract: The present technology relates to depots for the treatment of postoperative pain via sustained, controlled release of a therapeutic agent. In some embodiments, the depot may comprise a therapeutic region comprising an analgesic, and a control region comprising a bioresorbable polymer and a releasing agent mixed with the polymer. The releasing agent may be configured to dissolve when the depot is placed in vivo to form diffusion openings in the control region. The depot may be configured to be implanted at a treatment site in vivo and, while implanted, release the therapeutic agent at the treatment site for no less than 3 days.
    Type: Application
    Filed: April 3, 2020
    Publication date: August 6, 2020
    Inventors: Karun D. Naga, Stephen W. Boyd, Patrick H. Ruane, Jackie Joe Hancock, Michael Feldstein, Koot Kiat Teu, Honglei Wang, Jingnan Luo, Daniel Boon Lim Seet, Hanson S. Gifford, III
  • Patent number: 10669500
    Abstract: Described herein are coatings and formulations thereof for coating a substrate for use in producing a lubricious coating on a substrate surface that is to be inserted into the body lumen of a subject. Said coatings all contain an adhesion promoting coating formulation for applying to a substrate material that is formed from a polymeric adhesion promoter, a monomeric or polymeric crosslinking agent and a photoinitiator, where the polymeric adhesion promoter is a block copolymer comprising hydrophobic hydrophilic polymer blocks and/or a hydrophilic polymer comprising hydrophilic functional groups, where from 10% to 100% of the hydrophilic functional groups are capped with a hydrophobic functional group and the formulations thereof further contain a solvent to enable the coating to be applied to a substrate surface.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: June 2, 2020
    Assignees: JMEDTECH (XIAMEN) COATING TECHNOLOGY CO. LTD, JMEDTECH COATING TECHNOLOGIES PTE LTD
    Inventors: Jingnan Luo, Honglei Wang
  • Publication number: 20200009293
    Abstract: Disclosed herein are elastic, bioresorbable encasements for medical implants, methods for making the same and uses thereof.
    Type: Application
    Filed: September 27, 2017
    Publication date: January 9, 2020
    Inventors: Koon Kiat Teu, Jingnan Luo, Honglei Wang
  • Publication number: 20190351108
    Abstract: There is provided a controlled-release antibiotic socket for securely holding an implantable medical device that is made from: at least one film having at least one polymer layer, where the at least one film is formed into the socket; at least one antibiotic agent; and at least one opening in the socket, where the at least one polymer layer comprises a biodegradable elastomeric polymeric material; and the at least one antibiotic agent is dispersed within at least one of the at least one polymer layers and/or, when the film comprises at least two polymer layers, the at least one antibiotic agent is disposed as a separate layer between two polymer layers. Also disclosed is the film used to make the socket and uses of both the socket and film.
    Type: Application
    Filed: March 27, 2019
    Publication date: November 21, 2019
    Inventors: Honglei Wang, Jingnan Luo
  • Publication number: 20180200413
    Abstract: Disclosed herein is a drug-coated medical device in the form of a balloon having an inner surface and an outer hydrophobic surface, an adhesion balance layer directly on the outer hydrophobic surface of the balloon, comprising a hydrophilic polymer and/or a hydrophilic compound where the hydrophilic compound has a molecular weight of less than 1,000 Daltons, and a therapeutic layer directly on the adhesion balance layer comprising a therapeutic agent and a pharmaceutically acceptable carrier, wherein the therapeutic agent is a hydrophobic therapeutic agent with one or more hydrogen-bonding groups and is provided as discrete drug particles in the therapeutic layer, the drug particles have at least one dimension that is less than 25 ??? and are uniformly distributed on the surface of the balloon, and the pharmaceutically acceptable carrier is hydrophilic and has a molecular weight of less than 1,000 Daltons. A process to make the drug-coated medical device and uses thereof are also disclosed.
    Type: Application
    Filed: July 8, 2016
    Publication date: July 19, 2018
    Inventors: Jingnan LUO, Qian Yi Michele LEE, Honglei WANG
  • Publication number: 20180163152
    Abstract: Described herein are coatings and formulations thereof for coating a substrate for use in producing a lubricious coating on a substrate surface that is to be inserted into the body lumen of a subject. Said coatings all contain an adhesion promoting coating formulation for applying to a substrate material that is formed from a polymeric adhesion promoter, a monomeric or polymeric crosslinking agent and a photoinitiator, where the polymeric adhesion promoter is a block copolymer comprising hydrophobic hydrophilic polymer blocks and/or a hydrophilic polymer comprising hydrophilic functional groups, where from 10% to 100% of the hydrophilic functional groups are capped with a hydrophobic functional group and the formulations thereof further contain a solvent to enable the coating to be applied to a substrate surface.
    Type: Application
    Filed: June 8, 2016
    Publication date: June 14, 2018
    Inventors: Jingnan LUO, Honglei WANG