Patents by Inventor Jingrong Cao

Jingrong Cao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isoxazole compositions useful as inhibitors of ERK
    Patent number: 6649640
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors, especially inhibitors of ERK, having the formula: where A, B, R1, R2, T and Ht are described in the specification. The compounds are useful for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: November 18, 2003
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Michael Hale, James Janetka, Francois Maltais, Jingrong Cao
  • Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases
    Patent number: 6642227
    Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable derivative o thereof, wherein A, B, Ra, R1, R2, R3, and R4 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli; Lck and Src kinase. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
    Type: Grant
    Filed: April 10, 2002
    Date of Patent: November 4, 2003
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jingrong Cao, Jeremy Green, Young-Choon Moon, Jian Wang, Mark Ledeboer, Edmund Harrington, Huai Gao
  • Isoxazole compositions useful as inhibitors of ERK
    Publication number: 20030195241
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors, especially inhibitors of ERK, having the formula: 1
    Type: Application
    Filed: October 15, 2002
    Publication date: October 16, 2003
    Inventors: Michael Hale, James Janetka, Francois Maltais, Jingrong Cao, Robert Mashal
  • Inhibitors of c-Jun N-terminal kinases (JNK)
    Publication number: 20030153560
    Abstract: The present invention relates to inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
    Type: Application
    Filed: October 23, 2001
    Publication date: August 14, 2003
    Inventors: Francesco G. Salituro, Guy W. Bemis, Susanne Wilke, Jeremy Green, Jingrong Cao, Huai Gao, Edmund Martin Harrington
  • Inhibitors of c-Jun N terminal kinases (JNK) and other protein kinases
    Publication number: 20030149051
    Abstract: The present invention provides compounds of formula I: 1
    Type: Application
    Filed: February 12, 2002
    Publication date: August 7, 2003
    Inventors: Jeremy Green, Guy Bemis, Anne-Laure Grillot, Mark Ledeboer, Francesco G. Salituro, Edmund Harrington, Huai Gao, Christopher Baker, Jingrong Cao, Michael Hale
  • Pyrazole compositions useful as inhibitors of ERK
    Patent number: 6593357
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: where R1-4, Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
    Type: Grant
    Filed: August 22, 2002
    Date of Patent: July 15, 2003
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jeremy Green, Jingrong Cao, Michael Hale, Christopher Baker, Francois Maltais, James Janetka, Michael Mullican, Guy Bemis, Xiaoling Xie, Judith Straub, Qing Tang
  • Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases
    Publication number: 20030096816
    Abstract: The present invention provides compounds of formula I: 1
    Type: Application
    Filed: April 10, 2002
    Publication date: May 22, 2003
    Inventors: Jingrong Cao, Jeremy Green, Young-Choon Moon, Jian Wang, Mark Ledeboer, Edmund Harrington, Huai Gao
  • Compositions useful as inhibitors of GSK-3
    Publication number: 20030096813
    Abstract: The present invention provides compounds of formula I: 1
    Type: Application
    Filed: April 19, 2002
    Publication date: May 22, 2003
    Inventors: Jingrong Cao, Debbie Choquette, Robert Davies, Cornelia Forster, David Lauffer, Albert Pierce, Ronald Tomlinson, Marion Wannamaker, Natalie Metz
  • Heterocyclic inhibitors of ERK2 and uses thereof
    Publication number: 20030092714
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: 1
    Type: Application
    Filed: February 8, 2002
    Publication date: May 15, 2003
    Inventors: Jingrong Cao, Jeremy Green, Michael Hale, Francois Maltais, Judy Straub, Qing Tang, Alex Aronov
  • Pyrazole compositions useful as inhibitors of ERK
    Patent number: 6528509
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: where R1-4, Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: March 4, 2003
    Assignee: Vertex Pharmacuticals, Incorporated
    Inventors: Michael Hale, Xiaoling Xie, Jeremy Green, Jingrong Cao, Christopher Baker, Francois Maltais, James Janetka, Guy Bemis, Michael Mullican, Judith Straub, Qing Tang, Robert Mashal
  • Pyrazole compositions useful as inhibitors of ERK
    Publication number: 20030040536
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: 1
    Type: Application
    Filed: October 5, 2001
    Publication date: February 27, 2003
    Inventors: Michael Hale, Xiaoling Xie, Jeremy Green, Jingrong Cao, Christopher Baker, Francois Maltais, James Janetka, Guy Bemis, Michael Mullican, Judith Straub, Qing Tang, Robert Mashal
  • Isoxazole compositions useful as inhibitors of ERK
    Patent number: 6495582
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors, especially inhibitors of ERK, having the formula: where A, B, R1, R2, T and Ht are described in the specification. The compounds are useful for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
    Type: Grant
    Filed: September 14, 2001
    Date of Patent: December 17, 2002
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Michael Hale, James Janetka, Francois Maltais, Jingrong Cao, Robert Mashal
  • Isoxazole compositions useful as inhibitors of ERK
    Publication number: 20020177618
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors, especially inhibitors of ERK, having the formula: 1
    Type: Application
    Filed: September 14, 2001
    Publication date: November 28, 2002
    Inventors: Michael Hale, James Janetka, Francois Maltais, Jingrong Cao, Robert Mashal
  • Ring opening metathesis of alkenes
    Patent number: 6486324
    Abstract: Methods for performing ring-opening cross-metathesis reactions on solid support are disclosed. Substituted cyclic compounds, libraries of the compounds, and methods of using the compounds to treat bacterial infections are also disclosed.
    Type: Grant
    Filed: January 23, 2001
    Date of Patent: November 26, 2002
    Assignee: Sepracor Inc.
    Inventors: Gregory D. Cuny, Jingrong Cao, James R. Hauske
  • Pyrazole compositions useful as inhibitors of ERK
    Publication number: 20020151574
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: 1
    Type: Application
    Filed: October 5, 2001
    Publication date: October 17, 2002
    Inventors: Michael Hale, James Janetka, Francois Maltais, Jingrong Cao
  • Ring opening metathesis of alkenes
    Publication number: 20020042406
    Abstract: Methods for performing ring-opening cross-metathesis reactions on solid support are disclosed. Substituted cyclic compounds, libraries of the compounds, and methods of using the compounds to treat bacterial infections are also disclosed.
    Type: Application
    Filed: January 23, 2001
    Publication date: April 11, 2002
    Inventors: Gregory D. Cuny, Jingrong Cao, James R. Hauske
  • Ring opening metathesis of alkenes
    Publication number: 20010034341
    Abstract: Methods for performing ring-opening cross-metathesis reactions on solid support are disclosed. Substituted cyclic compounds, libraries of the compounds, and methods of using the compounds to treat bacterial infections are also disclosed.
    Type: Application
    Filed: January 23, 2001
    Publication date: October 25, 2001
    Inventors: Gregory D. Cuny, Jingrong Cao, James R. Hauske
  • Ring opening metathesis of alkenes
    Patent number: 6177464
    Abstract: Methods for performing ring-opening cross-metathesis reactions on solid support are disclosed. Substituted cyclic compounds, libraries of the compounds, and methods of using the compounds to treat bacterial infections are also disclosed.
    Type: Grant
    Filed: March 14, 1997
    Date of Patent: January 23, 2001
    Assignee: Sepracor, Inc.
    Inventors: Gregory D. Cuny, Jingrong Cao, James R. Hauske