Patents by Inventor Jingrong J. CUI

Jingrong J. CUI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DIARYL MACROCYCLE POLYMORPH
    Publication number: 20250223298
    Abstract: This disclosure relates to polymorphs of (7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14-tetrahydro-1,15-ethenopyrazolo[4,3-f][1,4,8,10] benzoxatriazacyclotridecin-4(5H)-one that are useful in the treatment of disease, such as cancer, in mammals. This disclosure also relates to compositions including such polymorphs, and to methods of using such compositions in the treatment of diseases, such as cancer, in mammals, especially in humans.
    Type: Application
    Filed: November 22, 2024
    Publication date: July 10, 2025
    Inventors: Jingrong J. Cui, Evan W. Rogers
  • Chiral diaryl macrocycles and uses thereof
    Patent number: 12310968
    Abstract: This disclosure relates to the use of certain diaryl macrocycle compounds, specifically (7S13R)-11-fluoro-7,13-di-methyl-6,7,13,14-tetrahydro-1,15-ethenopyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one in the treatment of disease in mammals. This disclosure also relates to compositions including such compounds, and to methods of using such compositions in the treatment of diseases in mammals, especially in humans.
    Type: Grant
    Filed: August 15, 2022
    Date of Patent: May 27, 2025
    Assignee: Turning Point Therapeutics, Inc.
    Inventors: Jingrong J. Cui, Yishan Li, Evan W. Rogers, Dayong Zhai, Wei Deng, Zhongdong Huang
  • Diaryl macrocycle polymorph
    Patent number: 12187739
    Abstract: This disclosure relates to polymorphs of (7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14-tetrahydro-1,15-ethenopyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one that are useful in the treatment of disease, such as cancer, in mammals. This disclosure also relates to compositions including such polymorphs, and to methods of using such compositions in the treatment of diseases, such as cancer, in mammals, especially in humans.
    Type: Grant
    Filed: September 19, 2022
    Date of Patent: January 7, 2025
    Assignee: TURNING POINT THERAPEUTICS, INC.
    Inventors: Jingrong J. Cui, Evan W. Rogers
  • MACROCYCLES AND THEIR USE
    Publication number: 20240182487
    Abstract: The present disclosure relates to macrocyclic compounds, pharmaceutical compositions containing macrocyclic compounds, and methods of using macrocyclic compounds to treat disease, such as cancer.
    Type: Application
    Filed: December 16, 2021
    Publication date: June 6, 2024
    Inventors: Jingrong J. CUI, Eugene RUI, Evan W. ROGERS
  • COMBINATION THERAPY INVOLVING DIARYL MACROCYCLIC COMPOUNDS
    Publication number: 20240033266
    Abstract: The present disclosure relates to methods and compositions for treating cancer with a diaryl macrocycle in combination with a KRAS inhibitor, such as an inhibitor of KRAS G12C.
    Type: Application
    Filed: April 24, 2023
    Publication date: February 1, 2024
    Inventors: Wei DENG, Dayong Zhai, Laura Rodon, Brion W. Murray, Jingrong J. Cui
  • COMBINATION THERAPY INVOLVING DIARYL MACROCYCLIC COMPOUNDS
    Publication number: 20230398119
    Abstract: The present disclosure relates to methods and compositions for treating cancer with a diaryl macrocycle in combination with an inhibitor of MAPK/ERK kinase-1 and -2 (MEK1 and MEK2; MAP2K1 and MAP2K2), such as trametinib.
    Type: Application
    Filed: April 26, 2023
    Publication date: December 14, 2023
    Inventors: Wei DENG, Dayong ZHAI, Laura RODON, Brion W. MURRAY, Jingrong J. CUI, Nathan V. LEE
  • CHIRAL DIARYL MACROCYCLES AND USES THEREOF
    Publication number: 20230346786
    Abstract: This disclosure relates to the use of certain diaryl macrocycle compounds, specifically (7S13R)-11-fluoro-7,13-di-methyl-6,7,13,14-tetrahydro-1,15-ethenopyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one in the treatment of disease in mammals. This disclosure also relates to compositions including such compounds, and to methods of using such compositions in the treatment of diseases in mammals, especially in humans.
    Type: Application
    Filed: August 15, 2022
    Publication date: November 2, 2023
    Inventors: Jingrong J. CUI, Yishan LI, Evan W. ROGERS, Dayong ZHAI, Wei DENG, Zhongdong HUANG
  • MACROCYCLES FOR USE IN TREATING DISEASE
    Publication number: 20230322806
    Abstract: The present disclosure relates to certain chiral diaryl macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat cancer.
    Type: Application
    Filed: March 17, 2023
    Publication date: October 12, 2023
    Inventors: Evan W. Rogers, Jane Ung, Vivian Nguyen, Dayong Zhai, Wei Deng, Jingrong J. Cui
  • DIARYL MACROCYCLE POLYMORPH
    Publication number: 20230295184
    Abstract: This disclosure relates to polymorphs of (7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14-tetrahydro-1,15-ethenopyrazolo[4,3-f][1,4,8,10] benzoxatriazacyclotridecin-4(5H)-one that are useful in the treatment of disease, such as cancer, in mammals. This disclosure also relates to compositions including such polymorphs, and to methods of using such compositions in the treatment of diseases, such as cancer, in mammals, especially in humans.
    Type: Application
    Filed: September 19, 2022
    Publication date: September 21, 2023
    Inventors: Jingrong J. Cui, Evan W. Rogers
  • Combination therapy involving diaryl macrocyclic compounds
    Patent number: 11666574
    Abstract: The present disclosure relates to methods and compositions for treating cancer with a diaryl macrocycle in combination with an inhibitor of MAPK/ERK kinase-1 and -2 (MEK1 and MEK2; MAP2K1 and MAP2K2), such as trametinib.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: June 6, 2023
    Assignee: Turning Point Therapeutics, Inc.
    Inventors: Wei Deng, Dayong Zhai, Laura Rodon, Brion W. Murray, Jingrong J. Cui, Nathan V. Lee
  • Combination therapy involving diaryl macrocyclic compounds
    Patent number: 11654145
    Abstract: The present disclosure relates to methods and compositions for treating cancer with a diaryl macrocycle in combination with a KRAS inhibitor, such as an inhibitor of KRAS G12C.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: May 23, 2023
    Assignee: Turning Point Therapeutics, Inc.
    Inventors: Wei Deng, Dayong Zhai, Laura Rodon, Brion W. Murray, Jingrong J. Cui
  • Macrocycles for use in treating disease
    Patent number: 11634433
    Abstract: The present disclosure relates to certain chiral diaryl macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat cancer.
    Type: Grant
    Filed: December 2, 2020
    Date of Patent: April 25, 2023
    Assignee: TURNING POINT THERAPEUTICS, INC.
    Inventors: Evan W. Rogers, Jane Ung, Vivian Nguyen, Dayong Zhai, Wei Deng, Jingrong J. Cui
  • MACROCYCLIC COMPOUNDS FOR TREATING DISEASE
    Publication number: 20220306652
    Abstract: The present disclosure relates to certain macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat disease, such as cancer.
    Type: Application
    Filed: February 14, 2022
    Publication date: September 29, 2022
    Inventors: Evan W. Rogers, Jingrong J. Cui, Dayong Zhai, Han Zhang, Jane Ung, Wei Deng, Jeffrey Whitten
  • Chiral diaryl macrocycles and uses thereof
    Patent number: 11452725
    Abstract: This disclosure relates to the use of certain diaryl macrocycle compounds, specifically (7S13R)-11-fluoro-7,13-di-methyl-6,7,13,14-tetrahydro-1,15-ethenopyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one in the treatment of disease in mammals. This disclosure also relates to compositions including such compounds, and to methods of using such compositions in the treatment of diseases in mammals, especially in humans.
    Type: Grant
    Filed: August 20, 2020
    Date of Patent: September 27, 2022
    Assignee: TURNING POINT THERAPEUTICS, INC.
    Inventors: Jingrong J. Cui, Yishan Li, Evan W. Rogers, Dayong Zhai, Wei Deng, Zhongdong Huang
  • Macrocyclic compounds for treating disease
    Patent number: 11286265
    Abstract: The present disclosure relates to certain macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat disease, such as cancer.
    Type: Grant
    Filed: May 5, 2020
    Date of Patent: March 29, 2022
    Assignee: TURNING POINT THERAPEUTICS, INC.
    Inventors: Evan W. Rogers, Jingrong J. Cui, Dayong Zhai, Han Zhang, Jane Ung, Wei Deng, Jeffrey Whitten
  • Macrocycles for use in treating disease
    Patent number: 11142533
    Abstract: The present disclosure relates to certain chiral diaryl macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat cancer.
    Type: Grant
    Filed: March 26, 2021
    Date of Patent: October 12, 2021
    Assignee: Turning Point Therapeutics, Inc.
    Inventors: Evan W. Rogers, Jane Ung, Vivian Nguyen, Dayong Zhai, Wei Deng, Jingrong J. Cui
  • MACROCYCLES FOR USE IN TREATING DISEASE
    Publication number: 20210246145
    Abstract: The present disclosure relates to certain chiral diaryl macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat cancer.
    Type: Application
    Filed: March 26, 2021
    Publication date: August 12, 2021
    Inventors: Evan W. Rogers, Jane Ung, Vivian Nguyen, Dayong Zhai, Wei Deng, Jingrong J. Cui
  • COMBINATION THERAPY INVOLVING DIARYL MACROCYCLIC COMPOUNDS
    Publication number: 20210220364
    Abstract: The present disclosure relates to methods and compositions for treating cancer with a diaryl macrocycle in combination with a KRAS inhibitor, such as an inhibitor of KRAS G12C.
    Type: Application
    Filed: November 25, 2020
    Publication date: July 22, 2021
    Inventors: Wei DENG, Dayong ZHAI, Laura RODON, Brion W. MURRAY, Jingrong J. CUI
  • MACROCYCLES FOR USE IN TREATING DISEASE
    Publication number: 20210163499
    Abstract: The present disclosure relates to certain chiral diaryl macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat cancer.
    Type: Application
    Filed: December 2, 2020
    Publication date: June 3, 2021
    Inventors: Evan W. Rogers, Jane Ung, Vivian Nguyen, Dayong Zhai, Wei Deng, Jingrong J. Cui
  • COMBINATION THERAPY INVOLVING DIARYL MACROCYCLIC COMPOUNDS
    Publication number: 20210154198
    Abstract: The present disclosure relates to methods and compositions for treating cancer with a diaryl macrocycle in combination with an inhibitor of MAPK/ERK kinase-1 and -2 (MEK1 and MEK2; MAP2K1 and MAP2K2), such as trametinib.
    Type: Application
    Filed: November 25, 2020
    Publication date: May 27, 2021
    Inventors: Wei DENG, Dayong ZHAI, Laura RODON, Brion W. MURRAY, Jingrong J. CUI, Nathan V. LEE